ID   N6SX90_DENPD            Unreviewed;       539 AA.
AC   N6SX90;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Mitochondrial-processing peptidase subunit alpha {ECO:0000256|ARBA:ARBA00016741};
DE   AltName: Full=Alpha-MPP {ECO:0000256|ARBA:ARBA00030006};
DE   AltName: Full=Inactive zinc metalloprotease alpha {ECO:0000256|ARBA:ARBA00032315};
DE   Flags: Fragment;
GN   Name=109543158 {ECO:0000313|EnsemblMetazoa:ENN72399};
GN   ORFNames=YQE_11033 {ECO:0000313|EMBL:ENN72399.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN72399.1};
RN   [1] {ECO:0000313|EMBL:ENN72399.1, ECO:0000313|Proteomes:UP000019118}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
RN   [2] {ECO:0000313|EnsemblMetazoa:ENN72399}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JAN-2017) to UniProtKB.
CC   -!- FUNCTION: Substrate recognition and binding subunit of the essential
CC       mitochondrial processing protease (MPP), which cleaves the
CC       mitochondrial sequence off newly imported precursors proteins.
CC       {ECO:0000256|ARBA:ARBA00002123}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; APGK01053465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APGK01053466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB741223; ENN72399.1; -; Genomic_DNA.
DR   RefSeq; XP_019768280.1; XM_019912721.1.
DR   AlphaFoldDB; N6SX90; -.
DR   MEROPS; M16.P01; -.
DR   EnsemblMetazoa; ENN72399; ENN72399; YQE_11033.
DR   GeneID; 109543158; -.
DR   KEGG; dpa:109543158; -.
DR   HOGENOM; CLU_009902_5_2_1; -.
DR   OMA; LKYHHSP; -.
DR   OrthoDB; 7099at2759; -.
DR   Proteomes; UP000019118; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   PANTHER; PTHR11851:SF49; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
FT   DOMAIN          85..234
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          240..443
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ENN72399.1"
SQ   SEQUENCE   539 AA;  60687 MW;  807F4DE5840B7A14 CRC64;
     MALQASKNLT SSIFQSKNTI WKGPNHLLRR CTSTEWSNLT ERPKKKVTDM PPMSEPVRGL
     PKAIYANFRE ENQHTKVTIM PNGLRVASEN RFGEFCTVGV VIDSGSRYEV AYPSGISHFL
     EKLAFNSTKH YPDRDEIINK LEKHGGICDS QASRDTFIYA ASAYTTGLND VIQLLAEATL
     RPQITPEEVD GAKQAIHFEL ETLHMRPEQE TILMDMIHAA AYRDNTLGLP KLCPSKNLDK
     IDREMLFLYL SQHYTPQRMV VAGVGVEHER LVEAVQKYFV DSKPLWEMEQ LFGKKNISGV
     DKSVAQYTGG IEQEECDIPQ FASAGLPVLS HIMIGLEGCS HQDSDFIAMC VLNMMMGGGG
     SFSAGGPGKG MYTRLYTNVL NRYHWMYSAT AYNHAYNDTG LFCIHASAPP NYVRDMVEVI
     VKELVNMASS IGDQELRRAK TQLQSMLLMN LESRPVMFED IGRQVLATAH RKRPEYFIKE
     IEKITKDDIV QVAKRLLMSQ PSVAARGDLR KMPSLEYIQA GLIDTEGKMP SGRKLSLWR
//