ID N6SZD4_DENPD Unreviewed; 955 AA.
AC N6SZD4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
DE Flags: Fragment;
GN ORFNames=D910_03413 {ECO:0000313|EMBL:ERL85999.1}, YQE_10265
GN {ECO:0000313|EMBL:ENN73124.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN73124.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN73124}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; APGK01050964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01050965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741180; ENN73124.1; -; Genomic_DNA.
DR EMBL; KB631768; ERL85999.1; -; Genomic_DNA.
DR AlphaFoldDB; N6SZD4; -.
DR STRING; 77166.N6SZD4; -.
DR EnsemblMetazoa; ENN73124; ENN73124; YQE_10265.
DR HOGENOM; CLU_004504_1_0_1; -.
DR OMA; LEYTTTG; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF7; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..955
FT /note="Peptidase S8/S53 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009707232"
FT TRANSMEM 909..928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..307
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 325..437
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 212
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 243
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 385
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN73124.1"
SQ SEQUENCE 955 AA; 107047 MW; AC8BE2592F623A26 CRC64;
MRGLRVVLLS LALCLQVLST NTQNYANNKE GPPKPGEAIL ESPLCCNLTV EHVDVDYTSK
IVENEYIVMF NGYYKSQARA TYIETALNNT GLKRWKIVDR ENPASDFPSD FDVIVLEDTE
SLQAGLKALN DHPAIKRVTA QRMVSRTLKF LSANERGTNT NSKEKLWQNG ARHHTSRKLL
RAVPKQITSV LQAGTLWAMG ITGKGIKVAI FDTGLSKSHP HFRKIKERTN WTNEKTFDDG
LGHGTFVAGV IASSKECLGF APDSELYIFR VFTNNQVSYT SWFLDAFNYA IMKKMNVLNL
SIGGPDFKDH PFVDKVWELT ANKMDVIGVG GINFEDQIAK FSSRGMTTWE LPQGYGRVKP
DIVTFGSAVK GSHIKGGCRT LSGTSVASPV VAGAITLLAS GVLHRGEDII NPASIKQALM
ASARRLPGAN MFEQGHGKLD LVKAHHILNS YKPQASLSPS YIDLSECPYM WPYCTQPLYY
GAVPLIVNVT ILNGMGVTGR IVGKPTWHPY TPQQGHFLEV SVAYSEELWP WSGWLGVSLS
VSLEGASYEG IAQGHITITV ESPPQNGEID PRSSTVELLV RAKIIPTPPR HKRILWDQYH
NLRYPPGYFP RDNLKVKNDP LDWNGDHIHT NFKDTYQNLR NAGYYVEVLG SSFNCFDASQ
YGTLLIVDPE EEYFPEEIAK LKRDVEAGLS VIVFADWYNV TVMEKVKFYD ENTRQWWMPD
TGGSNLPALN ELLSSWGIQL GDRTFAGHFK WNDHEMFYAS GNSIREFPDG GIVLGAELDD
QGAEDNQMHE WQVGAEVDSP ARLDTNRLYR FSKVLENHLD AGIVRALPQC PHLVWANPVP
LNQSAPGNLY QSQKLLALIE EEVNVPPENR NDNAENTIKD ASGAENGEEF IEWSWRNRPV
DSAEPSSHYD LSVTIFVFAA LVFCYICVRN YRRKPKKRKL CRKLITLIQC KKMSV
//
