ID   N6TEJ7_DENPD            Unreviewed;       932 AA.
AC   N6TEJ7;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
DE   Flags: Fragment;
GN   ORFNames=YQE_07329 {ECO:0000313|EMBL:ENN76158.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN76158.1};
RN   [1] {ECO:0000313|EMBL:ENN76158.1, ECO:0000313|Proteomes:UP000019118}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
RN   [2] {ECO:0000313|EnsemblMetazoa:ENN76158}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JAN-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; APGK01041006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APGK01041007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB740986; ENN76158.1; -; Genomic_DNA.
DR   AlphaFoldDB; N6TEJ7; -.
DR   EnsemblMetazoa; ENN76158; ENN76158; YQE_07329.
DR   HOGENOM; CLU_314042_0_0_1; -.
DR   OMA; WFNTSAV; -.
DR   Proteomes; UP000019118; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13751; TGF_beta_GDF8_like; 1.
DR   CDD; cd13752; TGF_beta_INHB; 1.
DR   Gene3D; 2.60.120.970; -; 3.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 2.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF292; INHIBIN BETA CHAIN; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 2.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 2.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 2.
DR   PROSITE; PS00250; TGF_BETA_1; 2.
DR   PROSITE; PS51362; TGF_BETA_2; 2.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           36..932
FT                   /note="TGF-beta family profile domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010971739"
FT   DOMAIN          302..413
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   DOMAIN          815..932
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ENN76158.1"
SQ   SEQUENCE   932 AA;  105345 MW;  BC9C00F10CEF823D CRC64;
     MLSPLRPFAQ CRPPAALKFF LIISALPFTI DGAKSASGYS HQVQPQDEPL STSLFDMAYP
     SMPASPPTST CSLCKRREEL KVRNLAIIKE EILKRMGFSQ PPNITGKVLP QVPSHYMAKI
     EEEHGMQGDQ PYKTGLTYTE EDDEYHVRTQ KVLTWAETHP RMRHMSWKVN DVLHFPFSDS
     ITKFHVANAT LNFFVRGGSE RMAGPHDVLI DIYKVVKFGD HSEPPELVRV KSWKEPWLPG
     RGKWIQTDFT ATVGEWFKNG KENFGFVINA TVNGKKLAVT DFNSEKSKAP YVETAVMEPK
     RRKRRNSGLN CDEKANEPLC CRYSFYVDFV EIGLDFIVAP KRYDAHMCSG ECPYLTLQKY
     PHTHLLKMAQ PNSAAPCCAP RKMSAISMLY FDDKLNLVLS SLPGMVHDSK SPLGWTLSVA
     CLYLVLSTAS GSLANGERLR HHHMKNQLEK TAVLEASSKM PLLGCPNCLF KHDRDREKLE
     SDKLRLEAIK RQILQKLGLR AKPNVTHSLP KEVVMATLSR AEDGDFTGAF GENPDFPTTS
     EKSGNLDTVE ADDFYGRTSE IISFAEQDGG DAASFWSRRH RSRVARPASR RRRPQNVPAH
     VRPTWISGEK AAVTSPQPYD GYAVGWSVPL RNCRPSQIEK LHFFAATLCI MCGFRPKVSQ
     PQALLFPCWK AEPERLDPVS PEAGSQMGQE FRVREASLWL KADLLKAPTS KCRSTDIFVF
     KIISNRLPES QFDRLTAEPI AVPLEEAASG WQKIDVTQTV SEWLGERAKD KLSLFVDCSC
     CAHWRIHLFN EESDQRSNPN RPFLVIHTDP STAKRVRRRA IDCSLDSGNQ CCKQRFYVSF
     KALGWEDWVI APQGYFANYC RGDCGQHRTP DTFVTYHTHV IEEVRKTQHL SGMTPCCAPL
     KFSTMSLIYY GPESTIIKRD LPKMVVEECG CP
//