ID N6TS93_DENPD Unreviewed; 739 AA.
AC N6TS93;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
DE Flags: Fragment;
GN ORFNames=YQE_12115 {ECO:0000313|EMBL:ENN71186.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN71186.1};
RN [1] {ECO:0000313|EMBL:ENN71186.1, ECO:0000313|Proteomes:UP000019118}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN71186}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU361242}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323,
CC ECO:0000256|RuleBase:RU361242}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680,
CC ECO:0000256|RuleBase:RU361242}.
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DR EMBL; APGK01056897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741277; ENN71186.1; -; Genomic_DNA.
DR AlphaFoldDB; N6TS93; -.
DR EnsemblMetazoa; ENN71186; ENN71186; YQE_12115.
DR HOGENOM; CLU_013477_0_1_1; -.
DR OMA; YISICHE; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF140; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 2.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|RuleBase:RU361242};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361242};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|RuleBase:RU361242};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361242};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361242}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361242"
FT DOMAIN 601..724
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN71186.1"
SQ SEQUENCE 739 AA; 84512 MW; D6CC945A8175A484 CRC64;
MLYGKLKIHT CRVILLTSLV WFLVDVVILS FYSECLGGSC NQKNPEALAQ IDGSKDYDNA
FDDNKIDEIQ PQRNSPSNSH GSGTGGISIT YRSHELKKWR IAPVVLPAGE LPGERGRAVN
IPPEQDELMK EKFKLNQFNL LASDKISLNR SLRDVRLDGC KSKVYPRLLP TTSIVIVFHN
EAWSTLLRTV WSVINRSPKA LLQEIILVDD ASERDYLGKK LEDYVKTLPV PVYVLRTNKR
SGLIRARLLG AEKVTGQVIT FLDAHCECTE GWLEPLLARI VQNRKTVVCP IIDVISDESF
EYITASDMTW GGFNWKLNFR WYRVSEREMN RRKGDRTAPL RTPTMAGGLF SIDKDYFYEI
GSYDEGMDIW GGENLEMSFR VWQCGGILEI SPCSRVGHVF RGQTPYTFPG GVTQIILKNL
ARVADVWLDE WREFYYVMNP GLAIVSANRG ITVEKVWQCG GILEINACSH VGHVFRDKSP
YTFPGGVSKI VLHNAARVAE VWMDHWKDFY YSMVPGHVFR KSTPYSFPGG TSRIVNHNNA
RLAEVWLDQW KDFYYNINPG ARNVAVGDVS KRKELREKLQ CKSFRWYLEN VYPESQMPLD
YYYLGDIRNM ETKNCLDTMG RKSSENLGMT YCHNMGGNQV FAYTKRQQIM NDDNCLDANG
KQGPVKLVRC HGMGGNQAWV YDEVDKTIKH VNTGSCLQKP DSKDVNLPLL RPCNYGEGQQ
WIMESDFKWQ ANNHHEEER
//
