ID N6TUF2_DENPD Unreviewed; 947 AA.
AC N6TUF2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
DE Flags: Fragment;
GN Name=109542507 {ECO:0000313|EnsemblMetazoa:ENN72905};
GN ORFNames=D910_09835 {ECO:0000313|EMBL:ERL92522.1}, YQE_10475
GN {ECO:0000313|EMBL:ENN72905.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN72905.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN72905}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU364117};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APGK01051866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741207; ENN72905.1; -; Genomic_DNA.
DR EMBL; KB632327; ERL92522.1; -; Genomic_DNA.
DR RefSeq; XP_019767311.1; XM_019911752.1.
DR RefSeq; XP_019767312.1; XM_019911753.1.
DR AlphaFoldDB; N6TUF2; -.
DR STRING; 77166.N6TUF2; -.
DR EnsemblMetazoa; ENN72905; ENN72905; YQE_10475.
DR GeneID; 109542507; -.
DR KEGG; dpa:109542507; -.
DR HOGENOM; CLU_001103_14_3_1; -.
DR OMA; TESKWLF; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364117}; Nucleus {ECO:0000256|RuleBase:RU364117};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 68..238
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 263..414
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 622..704
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 890..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN72905.1"
SQ SEQUENCE 947 AA; 105472 MW; 01CCBACB9DA2CE17 CRC64;
MEMDSLDDDL LNAFATQWEP TALESGSQNV VKSQATDKSD VPDSKSLEVL MTKFGHRQFR
PYQWQIISSI LKHKRDNCAI MTTGYGKSLC YQFPAVFSGG VTLVISPLIS LMEDQVLSLT
IANIPACLLG TAQKNTAQTI ADILKNKFSL VYLTPEFCTG EFGISLLKDM NSSLQITLIA
VDEAHCVSSW GHDFRHSYRQ LGMLKTLLPE VPVLAVTATA TERVKNDIIK SLKLLNPQLV
GTGFDRPNLY YAARPKGSSL FDDLKPLMTR KNGKWGFDGS TIIYCITRKD TANLSEVLQN
HQVSCLPYHA GLSLAVRKET HEQFVKDKIP VIIATIAFGM GIDKPDIRNV IHYGSSGSIE
SYYQEVGRAG RDGLPSKCVA FFSSQDFATH GFLIEKGQNS NRRAELLSTM KQYLNSRKCR
RAFLVSYFEG KADLSMPERS DCCDNCLAKT APSDQSIYEG VDERDFYDFT EDAVKYLSAI
SALGGKYGHG MYIMFVRGSK SSKIPDRLRS HPSFGTGKNK SDDWWKAIAN FLDLKHYLKQ
AKSKTASSFS FSVFDVSDEG LKFLNTPPDS RKLLEQPTLG ILHLLKKRQT TSGWISSGKA
PSVSGTVDVV DFAKTEETHQ EVDERLQLLR LLKNARSQLA RSNDCMPYMV ASDFILMEMA
RHKPRHLDQL RGMKIEGLTE ARIEKFGHQL LEVIKNNTAD VCKSSNRTLL DILKVHPIPG
AKVVSSSSIS YEYFTSCKSV DQVAAKRNLA LSTVFGHLVS LLKCGYPIKL EDLGVSSATK
QTILEAIRKL GGVVAELTPI KAQCPDDVTY DQIKCVCAYL HVRKHLKDLG VQFEDFDEPL
EELPLEESCD SEAGFDDHED SLLSALVDQM EQQITEDKKQ SLPNLREINQ SASKAPEEAP
PLKKSKLDDE PRVETLGPTN EVSMASEVKS SQSGKKKLPA WLMNKRV
//
