ID N6TZH1_DENPD Unreviewed; 7056 AA.
AC N6TZH1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Microtubule-actin cross-linking factor 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=YQE_08797 {ECO:0000313|EMBL:ENN74680.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN74680.1};
RN [1] {ECO:0000313|EMBL:ENN74680.1, ECO:0000313|Proteomes:UP000019118}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN74680}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
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DR EMBL; APGK01045638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01045639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741037; ENN74680.1; -; Genomic_DNA.
DR EnsemblMetazoa; ENN74680; ENN74680; YQE_08797.
DR HOGENOM; CLU_000015_2_1_1; -.
DR OMA; VPQRGQM; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 14.
DR Gene3D; 1.20.58.60; -; 27.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 13.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00435; Spectrin; 18.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 33.
DR SMART; SM00150; SPEC; 30.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 21.
DR SUPFAM; SSF46966; Spectrin repeat; 26.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6589..6624
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 6635..6670
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 6675..6747
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 64..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3780..3841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6457..6531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6853..7056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3164..3191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3867..3927
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4385..4416
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4460..4550
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4604..4631
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4715..4742
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5374..5419
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6205..6232
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 64..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3802..3841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6457..6482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6856..6881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6894..7041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7042..7056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN74680.1"
SQ SEQUENCE 7056 AA; 791668 MW; 4D85C46DCF58CB89 CRC64;
MGASEVGCSA DKRIASCKPI QLTRLVEQMQ PQPFRTFRTE FHMSSASEHT STYTTTTHYS
KQFVQTTKSS SSSRSENGTT IKISENKQDQ STDETDKIAN GRPPDKHTTL TQIIQEGPQN
WGTSMQFTEI KSLKRVHKVH EGIGTENITD IAGIINPYTG EQMTVRDAIL ERILDVRTGT
IIASPDGTQI SIEEAKTRGL IEPKVADKLQ SPCGIKEDGH ELTLLEAIQK DIFEAEQGLI
DPSEKRLKVS HSMTINQAID DGKVDVTSGT YRLESGGTID IKEAYKRGYL LQHTEVKLQT
EALALTDVIT QGLIDEVTGW IIDRNTGNKY QIDAATKCNI VEGDLREIVE PKSDSKITVL
QALDRGIINP KLGKFVLGHE KVSLLEAKRR QLIVKPKTLK EVVDDNLMDE EGKILSPLHQ
SRLTLLEAAN RGVLDIDQVK CIVDFRTNDL ITLNDALREG IILPEGKFRN SVTGETLTIQ
EAVSRGYIIS VVKKSIFDVD GFQPPDKSDH ISFNAAIAKG FISKKHDGSL LVNKKSGKLI
TFTEGIQSGQ VKPEVHEMLT RGVGIYENRK ELNVLEAVFK GHIDPKNGNL IDIKTNKVIY
LKEAIAQHLI TPEGAATLNS LLNLNVSTRI TRTLVQRYVT VTSKDVKQEI ITYTEALRLG
LINNEMQTFT DPITHQVIPI VQAISEGRLA PDVDSSEKVI APKSSAVITI VSRKEVPIHR
ESMQIDQQTV YSEKKSSENI HRESMQVDQQ SLYSEKKSSE KQVYELPSEG WLLSDAINQK
LFDPVTGLFI IPGTDRLASF EECVNLKLIC SNSATVLDPI SKRKMSITKA LEKKILDSTG
HYRIGNEKLT IEEAINRGFI ILEDSTQMAE SQRLLQITKS EGQPPKVEVS AVLDKNPPVY
TEVKIAQTGT AEPVELQPGI IYDPSINAVV YPDKNQAVDL ITAVLENKVS SDLVKVTDPF
TGKPMEIKEA IRRNIVDPEK EQYRDKVGQK MSLKDAARFG IITVVGAPIA AVTSVVKTIK
TLYVVNPKTG EKIPAEVALQ EGLIDLATYE KMQSELVENS QPITTTTTVT RTSLKVTDAK
TGKTYTSHEA LEQGLITPQQ MEELEQQNKE KVKLLDTATI SLSDESGPSE ADKTRARITT
EPTYRVKIGR AQSLSPDREA KKVVLQKLRR KIVRPEDAAK TGLLESEAVS LLADKANFIT
EEGETLTLQE ALEANKVDGN QGIIIDPQRG DQLTISQAIE RGILDPDGSS EILVPLNRSL
SIPEVIKQGL LDPATQKVVH PETGAHLSIS EAIICDIIDP LSTLVEKTGD KVTLSEALES
GVVDDETSVV ETKSGAKNLE DAVKDKVFDE ATPKGPLQLP PAGMTLSVAI KRGLVDSDTK
HIINPVTKES ISISEAIKDN FIMSLPFPPA PEGVKLDEAL ESQLIDTDAG TFKDPKSGET
YPVSEAVEKG MLIIKEPTSA VYFSAKPPVT TVTETVNTIH TVTTKTIEIL SGYALLNNQE
VQNVTTGQIL SIEEAKKQGI IKDVKETKNK TIIKDIHMSF SDALHKGLVD MKAGTYTDPN
SGESIPIQQA LQEGKISATP QITEESRESS VSTSKSTELN ISEAFETIYD SKSEKFLDLT
ENKEVTFKEA LDRDIIDPNS IIYDVAAQKT ISIAAAVDKG LIDSETGRIK DEKSGKSIDF
KEATKKGLIA VLGGLALPVI APVAAGVAAV NAVKDYAEKK KLEKKKEEKK VQEERKAMTI
QTVDSAQAKT STVHVIKKEE SIISSPDIVK ILPVGDAISQ NLINPKTCRI IYGNSELPYT
VQDGLSQNKI GPLDEIQIVS NNRVILVDVH KSAVISISKN MTAQKLAELG YYDLRRRLFI
DPQTGAHITF EDLVYELGVI DPDTVLVKDL TKKPAAYVTL HEALQRPLLD RQTGYMVDPK
TGKRVPFFEA VKLRWIIHVD DKPKEKFKPI TLQEIVKTEK FDHEKVEVAT ATETLPLIKA
LNANMVDPKS VTIRDPKNMQ LVPFYEAVDK QIVDPQRGLV VNTATQEIIP FSEAFLSGLV
LAIPRPISLQ AVIHKGMYDS ESFKIRDPLT NQLLSVQEAI ERQIVDAKIS EIKDTKEDVF
IILDDAIANK VIDAETGRMM DTNAGALVPF DKALELQLIR TKPVVFNLLQ VILANYYSPQ
SGLIMNPITG DEITLAKAIE YKLVDPVTTR IKDDRRGRIV EIHEAVESSL IDAEKGLLTN
PPLTLDQAYL KGYILSTVLP WSLQETLAQN VYDSTSGQIV FNDSNVTISQ AIEGGIVNPN
VLTVKDPKSG EIITLNEAIQ LKLIDPVKGQ AYDPISNSEM NLVEAQERGL IVPYKTQITL
PEAVFKGFYD PTTGKFINPK NKERLKASSA INRGYVDTSG TLVTIDEEIV TFDQAVTEGV
IDTNEGFILS YNEHVDFNEA FERGLLVEIR PPIPLSEAIA KGIYDEETQL FLDPQTGQYL
TLIEAIEISL IDAESVSVKD TRVGIWRKIS LIDAIHNNYV DGNTGKVRDF AKGENFEVSL
QKAFDMGILV DNKAAISLQR AIHQGLYDET TGKILDPSTD RKVTLHEAIR NFNVNPLLPC
YLDRREGRLY NLTETCRLGI IDKRSGTFKE PFTEKTIKLT EALNAGLIVD IESANFGLAE
ALELGLYIPE EGVFVHPASG RKFNLSESIE NELINPVTSL VKNSKLNKYV QLPVAIETRL
IDDQLSTYVF PHGKTIDLIE ARNKGLIVTA RTPLTLEETL RNSLYRPDSG KFADPVNNEF
YDLKQALENK FIDSQTTALK DATNNTTKSL LLAIEEGKID IEKGRVLDSK SKKTFNFDEA
FKRGLLITLT KPLEEEAVQK VVSDSAVSPR QLRECALDEA IKFDMLNPDE AVIKDLQTGK
FKTVAEAVKD GQLDLAKTVI FDVQAGKVKS LVVTYDQLLV IYLKEPIGFR QAVDSGLLSI
TSGKFTVPNT SEELSLKDSI ALGFVDPDSV LLKDSNKKKL IKLPEGFRKG LIDADKGNVL
DSATSKLYSL SAALESGLLI TPNMGFTLIE TIVYGIYNPT TGCFTDPFVT TSIIDRKKLT
LVEAIDENLV DPSTTVVKDL DGGTIEPLWQ AIESKVVDAV AGRIHDTVEK KEYDFVKALE
KGLILPAEQR QAVQEKYKLC DETLSKLLHW IGEVEDRIAS QDVIHEVEEE LRNQINSIKQ
IKDDLEQHSG QVSHCGDQVR QLVLTAGDIL SKSEVSALEK SSRNLKTRFD KAVDKTDKLL
RRQLAARDEL AKLKSELNLF STWLGKARRI LEDKERALSD LQRLDSSADS TRDFVSDVIA
HQADLRFITM SAQKFVDEGK EYLNILNDFR TSLPSRLPHI EPLSSQDSPV RSEVSLVTQQ
YRDLLHRANN LADRLSGVGG KQREYSDALD KARTWLKDAE PRANKLLNEP IGGDPKTVED
QLHKAKALNN EFVANGKLID NAKQATSALV RSLEGQISPS EIHRLEEPVE SLEGKYNSLS
GAIANRCQEL DTALVQSQGV QDALDGIIDW LNQAENQFKN MQRPASLIQE RLEEQLREHR
GFQSDIDTHI SSIDSVYLSA NELIVSTSNA RVAKQIEGKL TDVKTRFEKL FDRVQNRGVF
LGEVNRDLVA FNNQALKFEK WYSEIMEIIE SRDLAKAPAE QYALQMKEIA RNRDDNRALF
EEVVQIGKEL LNKRDVTDTT GVRDRVKNME SQWRDLENLM EEKTKLSKLR AEQHSAYETL
KEQVLDWLSR METKVTRLDL VAIHLETLRK QHDELKPISS EYKGYSSTID KVNDIGNAYD
SLIRGDRPES PSRRKGYSPT KRLSGRASQD ARSPSPTKGL SPLSPGGSSG FSSRRSSQDG
FHLEELSPVQ QQLSEINNRY SLLGVKINDR QSEIDQLREE LKKQLDNLKT LSAFLEKTQR
QLPKDVVPNT KDEADKLNKQ IKHVLEEMYE KQSLLDTTNS QVRDLLKRKA GAMGADNLND
ELEEVLSHWK SLSDHLKNRI KFMEDMKEFH DTHDSLATWL GAKERMLTVL GPISSDSRMV
QSQVQQVQVL REEFRSQQPQ LQHLVDVGDD VLSYLEPRSP DHQKINTKLT AIQQRWADIL
GKLEERAESL GAAADTSREF DAQLTRLRDA LQGISDNLDE VAFEKNPEDQ LRKVEHLERQ
LEGQRPLLAD LEANGAQLCE VLSDPASRAD IQSKLASVGR QYNALQKKLD LKKAEIEGSL
RDGRQFEASC AKTLGWLSDE LGSLSERLLI SADRDVLEQQ LAHHEPIYRD VLAREHEVIM
LLNKGREMVS RSTKTDTRGV QRDLDKIQQS WEKLRKEALD RQTRLKTCQE HCRKYYSVLE
SFLPWLRQAE DKIDSLRLQS FEKKHIEKQL KELQAFRNEV WKKSGEYENT RSLGDTFLSS
CDIDKDIVKN ELLELKERWE KLNNDLILRT QALEDQSRRL GDFNENLRDL KHGLDRCEDK
LASHDALGGA SRDPKLLDRI KALREETANL KKPLQSLRNQ AADLCHEATE NGIDANHLKD
EVESIGDRID DLQSKLNDRC SDLQSAATAV TQFNEKVKGL SHDLSGLEAE LDNMKPPARD
VKAVRGQIDD VVKFIGKVGK ASNDVEDAIL AGERLVDSGF APDTAQTRQQ VDALKRQLGK
LDDRAHNREK ELEGALKKLE DFYIGHAGVL DGIKDASDQL RKLKPIGSDV EGIRSQQKDF
KKFRAATVDP LNKNVETCNR VGQGLVQSAA SGVNTQTLEK DLEKMNDQWN TLKEKINDRE
RKLDIALLQS GKFQEALDGL AKWLADTEEL VANQKPPSAD YKVVKAQLQE QKFLKKMLLD
RQNSMSSLFS MGNEIAKEAD PSERKAIEKQ LKDLIGRFDA LTEGAQQRTL DLEHAMKVAK
EFQDKLLPLQ DWLERSEKKV KDMSLIPTDE EKIQQRIREH DALHNDILSK KPDFRELADV
ASNLMSLVGE DEAAGLADKL AEVTDRYGNL VEDSEKIGDL LTASRQGLRH LVLTYQDLAA
WMDSMEQRLA RYKVLAVHTD RLLEQMDDLT ALTEDIAGRQ ADVDGTVDAG VELMGHISSD
EALQLKDKLD SLQRRYNDLT SRGADLLKLA QNLLPLVQKF HNNHNRLVEW MQGAESVLQS
AEPNEGDIAR LEVDLQELRP VLETINVLGP QLCQASPGEG AATIEGLVSR DNRRFDAIAE
QIQRRAERIH LGKQRALEVT GDIDELLEWF REVESQIRDA EKPSAEPDVI RVQLKEHKAL
NDDISSQKGR VRDVLSTAKK VLRESPPSED TSLIREKMED LREAMDTVSA LSSDRLGILE
QALPLAEHFH DTHIGLVNWL GDMEEQVSML SMPALRPDAI AQQQDRNELF LQSINEHKPL
VDKLNKTGEA LIRLCNDDDG SKVQELLDND NARYAALKLE LRERQQALEQ ALQESSLFSD
KLEGMLRALT NTADQVNNQE PISAHVPKIR DQIEDNDAIV SDLDKRKEAY AAVQRAADDV
INKAGNRADS AVKDIKRKLD KLKNLWDDVQ KATKDRGHSL DNALDAAQKF WKELHAIMAT
LKDLEDSLVS QEPPAVEPKA IQEQQVALQE IRQEIDQTKP EVDQVRSSGQ KLMKLCGEPD
KPEVKKHIED LDNAWDNITA LYAKREENLI DAMEKAMEFH ETLQDLLAFL DKAERKFEKM
GPLGADIDAV KKQIEQLKNF KAEVDPHMVK VEALNRQAQE LTERTSADQA AAIKEPLSAV
NKRWDDLLRG MVDRQRQLEN ALLRLGQFQH ALNELLIWIS KTDKTLDELK PVAGDAQVLE
IELAKLKVLI NDIQAHQTSV DTLNDAGRQI IESGEDRYEA STTQEKLNTL NTQWRALVQK
AADRQRELED ALTDAHRFNA EIQDLLSWLG DVDGIIAASK PVGGLPETAS EQLERFMEIY
NEIEENRPKV ETVLAQGQEY LKKAPPNSAS NLQHNLRTLK QRWDSVTARA NDKKIKLEIA
LKEATEFHES LQAFVDWLTN AEKILNSLKP VSRVLDNVQQ QIEDHKVFQK DVSAHREIML
ALDKKGTHLK YFSQKQDVIL IKNLLISVQH RWERVAAKSA ERTRALDLGY KEAKEFHDSW
LGLMHWLDET EQNLDAFMLD TAGNDPDKIK ARLSKHHEFQ RALSAKQSSY DTVMKNGKQL
KEKAPKTDEP TLKQMLADLK GKWTSVCNKS VESQRKLEEA LLYSGQFKDA VAALMAWLKK
SEKELSQESP VHGDLDTVTH LFDLHRQFEK ELEKRNDQME SVMRNGQELE KTASKTDAAH
IRKQMTELNQ LWESVTGLTH LKTDRLHDAL KEAERLHKSV NMILDWLSDA EMKLRFVGNT
PEDEATAYEQ LKALDEFRAQ LSEKEIEKDQ TLNLAHNILA KAHPDSINVI KNWIKVIQSR
WEEVSQWALQ RHQKLSLHMQ SLRDMDETLE DLIQWLLGLE NTLIALKREE LPMNIPATEQ
LIADHKEFME NTQKRQAEVD RVCKAKQVKA AAGLKDPRKF GKAKAPIRGS QHDIHEHSSD
YGTLGRKQSF KGSRDLLSQR GSRASPGREL SPEPGYPHVG PRFSAPGSEP EFRSPRVKFL
YDKWRHVWVL SWERQRELYD HLAYLKEKEK ADNFSWDDWR KRFLKFMNYK KSRLTDLFRK
MDKDNNELIP RDDFIDGIIR TSKQRNQLEP EQFDTSRLEM KHVADMFDEN NRGLIDWKKF
IAALRPDWEE KTPDHDAQKI HDEVKRLVML CTCRQKFRVF QVGEGKYRFG DSQKLRLVRI
LRSTVMVRVG GGWVALDEFL LKNDPCRAKG RTNIELREQF ILADGVSQTM TAFKSKRSSA
SPVSGSSSTH EHMAELMPIF NEIRARGEIG NAYPLHVGST AGPTLHMAHV NPNTCYWVTL
ICVFLVRERS QRSVPMGSLP RHSKSTLSAG TPDSLSDNES GFRTPRKPVY RSTLTPGGSR
NNSRPASRTG SRPGSKPPSR HGSNQSLDST DDTPSRIPRR TPTSGFSSAT LSSARKSTVN
GTGSRPRTPS GLRSPASPAL RSASSNKVRQ VTIGVAPTLR TSSRTRTPSG SNTPVYPDQP
TAVSRLLRRN SGASETPTGQ ARRKKSTIED REPFRL
//