ID N6U422_DENPD Unreviewed; 647 AA.
AC N6U422;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
DE Flags: Fragment;
GN Name=109542075 {ECO:0000313|EnsemblMetazoa:ENN73337};
GN ORFNames=D910_07422 {ECO:0000313|EMBL:ERL90066.1}, YQE_10098
GN {ECO:0000313|EMBL:ENN73337.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN73337.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN73337}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; APGK01050349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01050350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741169; ENN73337.1; -; Genomic_DNA.
DR EMBL; KB632203; ERL90066.1; -; Genomic_DNA.
DR RefSeq; XP_019766689.1; XM_019911130.1.
DR AlphaFoldDB; N6U422; -.
DR STRING; 77166.N6U422; -.
DR EnsemblMetazoa; ENN73337; ENN73337; YQE_10098.
DR GeneID; 109542075; -.
DR KEGG; dpa:109542075; -.
DR HOGENOM; CLU_016467_0_0_1; -.
DR OMA; TVKFVIC; -.
DR OrthoDB; 2912447at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16476; RING-H2_RNF139-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025754; TRC8_N_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763:SF163; E3 UBIQUITIN-PROTEIN LIGASE RNF139; 1.
DR PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR Pfam; PF13705; TRC8_N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 71..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 579..617
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 626..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN73337.1"
SQ SEQUENCE 647 AA; 73948 MW; D01B5380B1DA4FF3 CRC64;
MSLRGKVLGL VEVLLRVPPI FVLDEIFKLG TEFIYGEITP NEFDSFGGQY DHRENANETA
FLLFDPTMSK FIFRTVVNVV VGAIVCLSAM CMFVLETKHL MVVYLYLTSI GVVITSVFAN
LRTVRTVLMD ESHLNGTLSP LQMFHDFDLK QLLNERGSMF QVTENYVIQT ILAFVFINIH
LGPRYTALQR LLPVSFLLPS LLVVLPVPDT FLRYSPIVSA LLPIAMVKFV LWSSFMAIAL
SLGTGYVKAK TFISNFGVSA LVESEWLRLN VPEVLRTFWI LRTVEHAGCF ILSDDWDLDD
VHSVYFRLLK YLLVSGCDTL TAVLGLTSVV SYICNYIGKF FQWILLTEDE NDKNFGTVSA
IVFYILALQT GLTSLEPEVR FIRLCRNFCL LFTALLHFTH NIVNPLLMSL SASHNPSLRR
HGHALVVCAV LVFLSFTLMY LLWTTQETST WLLAVTAFSI EVIVKVMVSL AIYSLFLYDA
RRETFWEKLD DYIYYIRSFG NTIEFCFGIF LFFNGAWILL FESGSAIRAI MMCIHAYFNI
WCDAKAGWSV FMKRRSAVNK IDSLPEADST QLQSLDDVCS ICYQEMFSAK ITKCKHFFHG
VCLRKWLYVQ DRCPLCHKIL HLNDESKSPP PQDPPLPDPL VEEEYNR
//
