ID N6UDE6_DENPD Unreviewed; 1720 AA.
AC N6UDE6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN ORFNames=YQE_03781 {ECO:0000313|EMBL:ENN79725.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN79725.1};
RN [1] {ECO:0000313|EMBL:ENN79725.1, ECO:0000313|Proteomes:UP000019118}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN79725}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; APGK01026933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01026934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01026935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740648; ENN79725.1; -; Genomic_DNA.
DR EnsemblMetazoa; ENN79725; ENN79725; YQE_03781.
DR HOGENOM; CLU_001645_4_2_1; -.
DR OMA; YWAAENE; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 9.
DR CDD; cd14553; R-PTPc-LAR-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 8.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 9.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1093..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..129
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 134..238
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 242..333
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 338..432
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 436..537
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 627..720
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 724..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 819..921
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1188..1442
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1362..1433
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1474..1720
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1651..1720
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 522..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN79725.1"
FT NON_TER 1720
FT /evidence="ECO:0000313|EMBL:ENN79725.1"
SQ SEQUENCE 1720 AA; 194548 MW; 272753DA22E64F01 CRC64;
MLLKFERILQ CLAIPMVFQM TIKLLDDIVN SKGEALPGPP TNVKTSEITA TSVRLTWSYP
GSEDLQYYVI QFKPKYANQA YSEISGIITM YYSVRNLSPY TEYEMYVIAV NNIGRGPPSA
PAVVTTGETE PGTAPRNVQV RPLSSSTMVI QWDEPETPNG QVTVRMRLYY TYIGYKVYYT
TNSQLTMAQW ESQVVDNNQL TTISELTPHT IYTIRVQAMT SVGPGPLSPP VHVKTQQGVP
SQPSNLRVSD IAESAVTLQW NKPTHSGESI VSYELYWNDT YAKEKHHRRI SITESYTLSG
LYPNSLYYVW LAARSQRGEG ATTPPIPVRT KQYVPGAPPS NVHGNAVSPT AIKVWWDPPP
ANRSNGNIIY YKLHFVEADR SDSEATINKM NATSFVLDEL KRWTTYRIWV LAGTSVGDGP
ASIPITVQTL EDVPGNPEDV KVTPINSTTI KVNWKPPKTN DRNGIILGYH VHVQEVKEES
KSFLNEPMQF NVLGGDTLEL NISSLQPDTT YAVQVAALTR KGDGDRSAPV DVRTPGGVPN
RPGLSLKITE RDPAVTFDLE WSRPSQTYGE LKGYRLRYGV KDQPLKEVPL KERGVEYEFR
VAGVNHIGTG QEAIKYIKTP EGPPTGPPTN ITCRFQTPDV VCVTWDPPTR EHRNGQIIKY
DIEFHKKSDH NNVIFRNVTK TKAVFTNLEE NTEYVFHIKA YTNLGPGPNS EKQTIQTEKD
IGRAPMAVKA VATSESSVEV WWETVPSRKP VIGYQIFYTM TAVEDLDAWQ QKSVGLTNSA
DLVNLEKYAQ YAIAVAARTE AGLGRLSEKD LVKVKPEDVP LNLRAHEVTT HSMTLSWAPP
IRLNPSQYKI SFDAIKEFVD SQGITQTQNI PRVEIVLRDE VKSYTINDLS PFTTYNVNVS
AIPSDESYRP PTKITVTTQM AAPQPMVKPD FYGVVKTEIH VILPQASEEY GPISHYYLIV
VPEDKSTIHK NPDQFLTEDL LSNVKDVAED PTLPYVAAKF PQRSIPYTFH LGTGEAKEGL
TNFKLKPDKR YRIFIRAVVD TPQKHLYTSS PFSEFLSLDM RAPPPGEVPT RPNPNVPTDT
DVKVSSQRKE ATYLWVIGPV IAAVLLCSIL VFLFLLRRRR QPCKTPDQAA VTKPLIPADL
NSSIAPSDPV EQRRLNFQTP AMISHPPIPV SELANHIERL KANDNLKFSQ EYESIEPGQT
FTWEFSNMDV NKPKNRYANV ISYDHSRVIL PLEDGRRGSD YINANYCDGY RKHNAYVATQ
GPLPETFGDF WRMCWELKAA TIVMMTKLEE RTRIKCDQYW PSRGTEVYGP MSVVISDVQE
LATYCIRTFQ IQKDFEESRE IKQLQFTAWP DHGVPDHPAP FLQFLRRVRS LNPPEAGPII
VHCSAGVGRT GCFIVIDSML ERMRHEKTVD IYGHVTCLRA QRNYMVQTED QYIFIHDSLL
EAYICGATEV PARNLHPHIQ KLMQLEPGEN ITGMEHEFKK LGNIKTDSSR FVTANLPCNK
HKNRLVHILP YESTRVCLQP IRNIDGSDYI NGSFIDGYRY RKAYIATQGP LPDTTDDLWR
MLWEHNSTII VMLTKLKEMG REKCHQYWPS DRSVRYGCYV VDPIAEYNMP QYILREFKVT
DARDGSSRTM RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR
TGVFITLSIV LERMQYEGVV DVFQTARILR TQRPAMVQTE
//
