ID N6US50_BARVB Unreviewed; 472 AA.
AC N6US50;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=TldD protein {ECO:0000313|EMBL:ENN95169.1};
GN Name=tldD {ECO:0000313|EMBL:ENN95169.1};
GN ORFNames=BVtw_04450 {ECO:0000313|EMBL:ENN95169.1};
OS Bartonella vinsonii subsp. berkhoffii str. Tweed.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=1094502 {ECO:0000313|EMBL:ENN95169.1, ECO:0000313|Proteomes:UP000014011};
RN [1] {ECO:0000313|EMBL:ENN95169.1, ECO:0000313|Proteomes:UP000014011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tweed {ECO:0000313|EMBL:ENN95169.1};
RX PubMed=23555299; DOI=10.1371/journal.pgen.1003393;
RA Guy L., Nystedt B., Toft C., Zaremba-Niedzwiedzka K., Berglund E.C.,
RA Granberg F., Naslund K., Eriksson A.S., Andersson S.G.;
RT "A gene transfer agent and a dynamic repertoire of secretion systems hold
RT the keys to the explosive radiation of the emerging pathogen Bartonella.";
RL PLoS Genet. 9:E1003393-E1003393(2013).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENN95169.1}.
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DR EMBL; AGWD01000009; ENN95169.1; -; Genomic_DNA.
DR RefSeq; WP_010704858.1; NZ_KB915632.1.
DR AlphaFoldDB; N6US50; -.
DR PATRIC; fig|1094502.3.peg.528; -.
DR HOGENOM; CLU_026425_1_0_5; -.
DR Proteomes; UP000014011; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 30..91
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 118..227
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 235..468
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 472 AA; 50812 MW; BB13B1FB94EF087E CRC64;
MKSLIDHFDI DSSKVQSLVQ ETLHHADDGE LYLEYTESET LLFDNGQLKN GSFHQDMGFG
LRVVAGEATG YAHSSELTAA ALKRASEAAK AVTYNNHTGP YSVAPQQTNK RLYQPLNPLD
TPSFEDKSAL LQKIDAYLRA KNDKLHQVTV SLSGSLQHIE ILRADGHLIR DIRPLVRLSI
SVVAAEGNRR ENGFYGCGGR QAFSQFIHEE NWKKAADEAL RMALINLEAE AAPAGTFDVV
LANGWPGVML HEAVGHGLES DFNRKKTSAF AGLLGQQVAA KGVTVVDDGT IPQCRGSLTV
DDEGTPSGYN VLIEDGKLIG FMQDRLNARL MGVHPTGNGR RESYAHAPIP RMTNTMMLGG
DKTPEEILSS LKNGIYAVSF GGGQVDITSG KFVFECTEAY RVENGKIVAP IKGATLIGNG
PDAMKHITMI GNDSKLDNGI GMCGKAGQNV PVGVGQPHLR INNMTIGGTA LS
//
