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Database: UniProt
Entry: N6X068_9RHOO
LinkDB: N6X068_9RHOO
Original site: N6X068_9RHOO 
ID   N6X068_9RHOO            Unreviewed;       723 AA.
AC   N6X068;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE            EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN   ORFNames=B447_20538 {ECO:0000313|EMBL:ENO74986.1};
OS   Thauera sp. 27.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC   Thauera.
OX   NCBI_TaxID=305700 {ECO:0000313|EMBL:ENO74986.1, ECO:0000313|Proteomes:UP000013140};
RN   [1] {ECO:0000313|EMBL:ENO74986.1, ECO:0000313|Proteomes:UP000013140}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=27 {ECO:0000313|EMBL:ENO74986.1,
RC   ECO:0000313|Proteomes:UP000013140};
RA   Liu B., Shapleigh J.P., Frostegard A.H.;
RT   "Draft Genome Sequences of 6 Strains from Genus Thauera.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922};
CC   -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC       {ECO:0000256|ARBA:ARBA00008465}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ENO74986.1}.
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DR   EMBL; AMXB01000064; ENO74986.1; -; Genomic_DNA.
DR   RefSeq; WP_002934063.1; NZ_AMXB01000064.1.
DR   AlphaFoldDB; N6X068; -.
DR   eggNOG; COG1884; Bacteria.
DR   eggNOG; COG2185; Bacteria.
DR   Proteomes; UP000013140; Unassembled WGS sequence.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR   CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR   CDD; cd03679; MM_CoA_mutase_alpha_like; 1.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR   InterPro; IPR006159; Acid_CoA_mut_C.
DR   InterPro; IPR016176; Cbl-dep_enz_cat.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR036724; Cobalamin-bd_sf.
DR   InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR   InterPro; IPR006098; MMCoA_mutase_a_cat.
DR   NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR   NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR   PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF01642; MM_CoA_mutase; 1.
DR   SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR   SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
DR   PROSITE; PS00544; METMALONYL_COA_MUTASE; 1.
PE   3: Inferred from homology;
KW   Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW   Cobalt {ECO:0000256|ARBA:ARBA00022628};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ENO74986.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013140}.
FT   DOMAIN          592..723
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
SQ   SEQUENCE   723 AA;  78565 MW;  ACE18113E3783291 CRC64;
     MSQSNQSNEP TYNQADIEAW NKAAAKHAPG GDVTKLNWVT PEGLVVKPLY TKADTADLKH
     ADTLPGFEPF LRGPQPTMYA VKPWTIRQYA GFSTAEASNA FYRKALAAGG QGVSVAFDLA
     THRGYDSDHP RVTGDVGKAG VAIDSVEDMK ILFDGIPLDK ISVSMTMNGA VLPILAGYII
     AAEEQGVSQD KLSGTIQNDI LKEFMVRNTY IYPPTPSMKI IADIFQYTSA NMPKFNSISI
     SGYHIQEAGA NQAIELAFTL ADGLEYVRTG IASGMDVDTF AGRLSFFWAV GMNFYLEIAK
     MRAARLLWWR IMKQFNPKSP KSMMLRTHSQ TSGWSLTEQD PYNNVVRTTI EAMAAVFGGT
     QSLHTNALDE AIALPTEFSA RIARNTQIII QEETHICNVV DPWAGSYMME KLTQDMADKA
     WALIEEIESM GGMTKAVESG WAKMKVEECA ADKQARIDSG KDVIVGVNKY KLAKEDPIEI
     LDIDNHAVRE SQIARLAQVR ANRDTAAVQA ALDALTKCAE TGDGNLLDLT VKAIRLRATV
     GEVSDALEKV FGRYRANPQA VSGVYGAVVE EQEDWKALKA DIEAFIAEEG RRPRVMIAKL
     GQDGHDRGAK VVASAFADLG FDIDIGPLFQ TPEEAARHAV ENDVHAVGCS SLAAGHKTLV
     PQIVNELKRL GADDIITFVG GVIPAQDYDA LYAAGAKGIF GPGTPIPTAA REVLKQIRAA
     RKA
//
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