ID N6X1W7_9ACTO Unreviewed; 652 AA.
AC N6X1W7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Xanthine/uracil permease {ECO:0000313|EMBL:ENO17432.1};
GN Name=pbuX {ECO:0000313|EMBL:ENO17432.1};
GN ORFNames=HMPREF9004_1838 {ECO:0000313|EMBL:ENO17432.1};
OS Schaalia cardiffensis F0333.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Schaalia.
OX NCBI_TaxID=888050 {ECO:0000313|EMBL:ENO17432.1, ECO:0000313|Proteomes:UP000013015};
RN [1] {ECO:0000313|EMBL:ENO17432.1, ECO:0000313|Proteomes:UP000013015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0333 {ECO:0000313|EMBL:ENO17432.1,
RC ECO:0000313|Proteomes:UP000013015};
RA Aqrawi P., Ayvaz T., Bess C., Blankenburg K., Coyle M., Deng J., Forbes L.,
RA Fowler G., Francisco L., Fu Q., Gibbs R., Gross S., Gubbala S., Hale W.,
RA Hemphill L., Highlander S., Hirani K., Jackson L., Jakkamsetti A.,
RA Javaid M., Jayaseelan J.C., Jiang H., Joshi V., Korchina V., Kovar C.,
RA Lara F., Lee S., Liu Y., Mata R., Mathew T., Munidasa M., Muzny D.,
RA Nazareth L., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F.,
RA Palculict T., Patil S., Petrosino J., Pham C., Pham P., Pu L.-L., Qin X.,
RA Qu J., Reid J., Ross M., Ruth R., Saada N., San Lucas F., Santibanez J.,
RA Shang Y., Simmons D., Song X.-Z., Tang L.-Y., Thornton R., Warren J.,
RA Weissenberger G., Wilczek-Boney K., Worley K., Youmans B., Zhang J.,
RA Zhang L., Zhao Z., Zhou C., Zhu D., Zhu Y.;
RT "Reference genome for the Human Microbiome Project.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENO17432.1}.
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DR EMBL; AQHZ01000028; ENO17432.1; -; Genomic_DNA.
DR RefSeq; WP_005964776.1; NZ_KB822675.1.
DR AlphaFoldDB; N6X1W7; -.
DR STRING; 888050.HMPREF9004_1838; -.
DR PATRIC; fig|888050.3.peg.1759; -.
DR eggNOG; COG2233; Bacteria.
DR eggNOG; COG3195; Bacteria.
DR HOGENOM; CLU_017959_8_2_11; -.
DR OrthoDB; 9805749at2; -.
DR Proteomes; UP000013015; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR SUPFAM; SSF158694; UraD-Like; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000013015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 476..630
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
SQ SEQUENCE 652 AA; 68724 MW; DC49626AF5B36ACD CRC64;
MALGRSAGAT TPDHRHPVDQ VPPAGKLAVL GIQHVLAFYA GAVVVPLVIA SALGLDEQTL
VHLINADLFT CGIATIIQSA GLGPKIGVKL PLIQGVTFTA VSPLIAIGIG ASPAGADPKT
GLATMYGSII AAGLATFLIA PYFAKLLRFF PPVVTGTLLT VMGITLIAVS AGDIVSLASY
APEGADLGAL TLKGLAYAMG TLAIIVAIQK IFKGFMSTIS VLLGLVVMTI IAFILKDASF
SNVAQSSWVG ITSPFFFGLP KFSVAAIISM LIVMAVTAVE TTGDVFATGE VVGKRITPEH
VARALRADGL STLLGGVLNS FPYTCFAQNV GLVRLTRVKS RWVVTAAGVI MIILGLLPKA
GAIVASIPAP VIGGASLAMF ANVAVVGIQT LGKVDMRDNR NAVIVSTSVG LAMLVTLKPE
IATMVPSWLQ IIFGSGVTIG ALSAFILNLL FFHLGKQQGP DVALVDGRAV SIDEVNSMER
DVFIRAFSGM YEGATWPVER AWEQRPFADT TELRRAFEDE VLVASLEEQE ALIAAYSDIA
ELAAGKGDER ANQDTAALGL GEFDDKELED LTAASAAYRE KFHRPLVVCV TNLADREHLI
SSAWKRVETS KAREARFALG EVIDIADERF TQLVADANPI RTAWARKMDQ VD
//
