ID N6X3C7_9ACTO Unreviewed; 444 AA.
AC N6X3C7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=O-acetylhomoserine sulfhydrylase {ECO:0000313|EMBL:ENO17947.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:ENO17947.1};
GN Name=metY {ECO:0000313|EMBL:ENO17947.1};
GN ORFNames=HMPREF9004_1219 {ECO:0000313|EMBL:ENO17947.1};
OS Schaalia cardiffensis F0333.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Schaalia.
OX NCBI_TaxID=888050 {ECO:0000313|EMBL:ENO17947.1, ECO:0000313|Proteomes:UP000013015};
RN [1] {ECO:0000313|EMBL:ENO17947.1, ECO:0000313|Proteomes:UP000013015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0333 {ECO:0000313|EMBL:ENO17947.1,
RC ECO:0000313|Proteomes:UP000013015};
RA Aqrawi P., Ayvaz T., Bess C., Blankenburg K., Coyle M., Deng J., Forbes L.,
RA Fowler G., Francisco L., Fu Q., Gibbs R., Gross S., Gubbala S., Hale W.,
RA Hemphill L., Highlander S., Hirani K., Jackson L., Jakkamsetti A.,
RA Javaid M., Jayaseelan J.C., Jiang H., Joshi V., Korchina V., Kovar C.,
RA Lara F., Lee S., Liu Y., Mata R., Mathew T., Munidasa M., Muzny D.,
RA Nazareth L., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F.,
RA Palculict T., Patil S., Petrosino J., Pham C., Pham P., Pu L.-L., Qin X.,
RA Qu J., Reid J., Ross M., Ruth R., Saada N., San Lucas F., Santibanez J.,
RA Shang Y., Simmons D., Song X.-Z., Tang L.-Y., Thornton R., Warren J.,
RA Weissenberger G., Wilczek-Boney K., Worley K., Youmans B., Zhang J.,
RA Zhang L., Zhao Z., Zhou C., Zhu D., Zhu Y.;
RT "Reference genome for the Human Microbiome Project.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENO17947.1}.
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DR EMBL; AQHZ01000021; ENO17947.1; -; Genomic_DNA.
DR RefSeq; WP_005963386.1; NZ_KB822674.1.
DR AlphaFoldDB; N6X3C7; -.
DR STRING; 888050.HMPREF9004_1219; -.
DR PATRIC; fig|888050.3.peg.1159; -.
DR eggNOG; COG2873; Bacteria.
DR HOGENOM; CLU_018986_4_0_11; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000013015; Unassembled WGS sequence.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000013015};
KW Transferase {ECO:0000313|EMBL:ENO17947.1}.
FT MOD_RES 213
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 444 AA; 47198 MW; 08CEBECC48AECA36 CRC64;
MTQSNAQNWK FETQQVHAGW DRDPATGATA LPIHMSNGFA FESAEQAADR FSLRQIGNIY
TRLSNPTNDS LEARVAALEG GVGALFLASG QSATALSILN LADTGNNIVA SGSLYGGTVT
LLKNSLGRLG IEVRFVSDPL NAEAWKALAD AKTVAFFGEA IPNPRGDILD IEPIAQAAHE
VGVPLIVDNT VSTPYLTRPF EWGADIVVHS ASKSLGGHGT TMGGFIVDSG HFDYSADPKR
FPHFNTPDPS YGGIIYARDL GEEGAFGANL SYILRARLLG QRDFGFVPSP FNAFLIESGI
QTLSLRIERA TDNALAVARY LEAHPQVESV NYAGLESSPL HHLHLKYCPR GAGPLLSFVI
KGGYEAGRAF ANSLELLPLI ANLGDNKTLA THPASMTHSQ LSPSQLEAAG IEGGTFRLSI
GIEHIDDIIA DLEIGFTAAS TVAS
//
