ID N6X3N7_9ACTO Unreviewed; 812 AA.
AC N6X3N7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=von Willebrand factor, type A {ECO:0000313|EMBL:ENO18052.1};
GN ORFNames=HMPREF9004_1177 {ECO:0000313|EMBL:ENO18052.1};
OS Schaalia cardiffensis F0333.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Schaalia.
OX NCBI_TaxID=888050 {ECO:0000313|EMBL:ENO18052.1, ECO:0000313|Proteomes:UP000013015};
RN [1] {ECO:0000313|EMBL:ENO18052.1, ECO:0000313|Proteomes:UP000013015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0333 {ECO:0000313|EMBL:ENO18052.1,
RC ECO:0000313|Proteomes:UP000013015};
RA Aqrawi P., Ayvaz T., Bess C., Blankenburg K., Coyle M., Deng J., Forbes L.,
RA Fowler G., Francisco L., Fu Q., Gibbs R., Gross S., Gubbala S., Hale W.,
RA Hemphill L., Highlander S., Hirani K., Jackson L., Jakkamsetti A.,
RA Javaid M., Jayaseelan J.C., Jiang H., Joshi V., Korchina V., Kovar C.,
RA Lara F., Lee S., Liu Y., Mata R., Mathew T., Munidasa M., Muzny D.,
RA Nazareth L., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F.,
RA Palculict T., Patil S., Petrosino J., Pham C., Pham P., Pu L.-L., Qin X.,
RA Qu J., Reid J., Ross M., Ruth R., Saada N., San Lucas F., Santibanez J.,
RA Shang Y., Simmons D., Song X.-Z., Tang L.-Y., Thornton R., Warren J.,
RA Weissenberger G., Wilczek-Boney K., Worley K., Youmans B., Zhang J.,
RA Zhang L., Zhao Z., Zhou C., Zhu D., Zhu Y.;
RT "Reference genome for the Human Microbiome Project.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENO18052.1}.
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DR EMBL; AQHZ01000020; ENO18052.1; -; Genomic_DNA.
DR RefSeq; WP_005963314.1; NZ_KB822674.1.
DR AlphaFoldDB; N6X3N7; -.
DR STRING; 888050.HMPREF9004_1177; -.
DR PATRIC; fig|888050.3.peg.1116; -.
DR eggNOG; COG2304; Bacteria.
DR eggNOG; COG2755; Bacteria.
DR HOGENOM; CLU_347391_0_0_11; -.
DR OrthoDB; 5503950at2; -.
DR Proteomes; UP000013015; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR CDD; cd01823; SEST_like; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR037460; SEST-like.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR37981; LIPASE 2; 1.
DR PANTHER; PTHR37981:SF1; SGNH_HYDRO DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637460-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013015};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..812
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004127452"
FT TRANSMEM 778..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..242
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 673..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 370
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-1"
FT ACT_SITE 617
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-1"
FT DISULFID 386..407
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
FT DISULFID 528..589
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
SQ SEQUENCE 812 AA; 85903 MW; 757DD1399E942692 CRC64;
MRQRRLWRSL ITSTFVTFCL TATILPTLAA PQSGNTPSEA TTFEDAPLAI LFDVSGSMNE
ADSNGVNKLS AAKTSMTTML REQSGTRTRL GLWTYPGTLT DNQGCQPGTW IPGLSPTQTP
DPTDLDATIR TLSANGGTPT GPALSALIDN LKREGFTAAT IILVSDGESN CGVPPCEIAQ
QAGAEGFKLH VPTVGFDISE QGRRELECIA NATGSTYHDA EDAEKLITEL EKYQPKDLRL
EVNAPAMILP GANAQIIATI HNPSPAPVVG AKAILALDRG GSQRSFTTVL APQRPLAAIP
AGGSVTVKWI ATSATNARGA ASWKIAVGSP EAGAALATGT INFAENDLTM NDAGPLLKNL
HGPVVVLGDS YSSGEGTGSY ITNNKCHRST LAYGAVLGGQ TTDIIACSGA TSADIRNRNQ
NDTELPQVQA LSALTTPPGI VFMTIGGNDI GFADIVLNCL VNDCASNMGA QRRKLSEITL
MSESLEDTLR QVVEAANTPE WVAKRGAVAP LIVSPYPDLL WQTGRGTCAS NTPVSNYGFS
TEEMTYGRSV LMTLNRQLET AVDKLASVGY PIVYADSVLD FPQPSHTICD SDSYFVQLDI
GNVLNQAWKL QLRELAHPNA RGHRAWANEL ISWSQTDRAS NTSSTMPDRP SRISLRGIIR
LFENLISRSV SVKGELQPPT GDGSAQPGAT HQRIDVRNAD TIQLDLRGAR PGSVITIVVH
SAPTALGTIP VDEDGVAHGQ VTIPHDLPAG SHTLVVSGLN DNFEQVLFET PLKVSTSLSL
PLIAGVASLL FSTIGIALAL LGRSQLRKAH AT
//
