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Database: UniProt
Entry: N6YEF7_9RHOO
LinkDB: N6YEF7_9RHOO
Original site: N6YEF7_9RHOO 
ID   N6YEF7_9RHOO            Unreviewed;       497 AA.
AC   N6YEF7;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   30-AUG-2017, entry version 30.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ENO78349.1};
GN   ORFNames=C664_08368 {ECO:0000313|EMBL:ENO78349.1};
OS   Thauera sp. 63.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Zoogloeaceae; Thauera.
OX   NCBI_TaxID=497321 {ECO:0000313|EMBL:ENO78349.1, ECO:0000313|Proteomes:UP000013007};
RN   [1] {ECO:0000313|EMBL:ENO78349.1, ECO:0000313|Proteomes:UP000013007}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=63 {ECO:0000313|EMBL:ENO78349.1,
RC   ECO:0000313|Proteomes:UP000013007};
RA   Liu B., Shapleigh J.P., Frostegard A.H.;
RT   "Draft Genome Sequences of 6 Strains from Genus Thauera.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ENO78349.1}.
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DR   EMBL; AMXC01000007; ENO78349.1; -; Genomic_DNA.
DR   EnsemblBacteria; ENO78349; ENO78349; C664_08368.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000013007; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000013007};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013007}.
FT   DOMAIN      194    325       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      405    474       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     202    209       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   497 AA;  56018 MW;  87DCE223209B9957 CRC64;
     MPHIYSDTAV TEELWPFCLS RLEQELPQQQ YNTWIKTLRA EAGEDGTFRL IAPNRFVLQW
     VRERYLSRIH ELSETFTGGP LQIELQLPPV STARTSRPAT ATATTAPART TPSAHDAAEQ
     PAAADTAAPS RAPRAPAVIA SREPEPAAAS SGLELAYEKT RLNPDFTFDT LVTGRANDLA
     RAAAMQVAQN PGTSYNPLFV YGGVGLGKTH LVHAIGNAVF RHNPRAVVRY VHVEDYYADV
     VRAYQQKSFD AFKRYYRSLD MLIIDDIQFF NNKNRTQEEF FHAFNALTEA RKQIVITCDT
     YPKDIQGLED RLISRFDWGL TVQIEPPELE MRVAILKKKA EALRVSVDDD VAFLIAKNLR
     SNVRELEGAL NKVVAYARFH GRQISLEVAK EALKDLLHAH NRQLSIEHIQ KTVADYYKIK
     VADMHSKKRT RVIARPRQVA MWLAKELTPM SLPAIGEAFG GRDHTTVLHA CRTITELRLG
     DHQLNHDVHV LTQVLRG
//
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