ID N8RJP0_9GAMM Unreviewed; 576 AA.
AC N8RJP0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=F989_01250 {ECO:0000313|EMBL:ENU33764.1};
OS Acinetobacter parvus NIPH 1103.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1217671 {ECO:0000313|EMBL:ENU33764.1, ECO:0000313|Proteomes:UP000018426};
RN [1] {ECO:0000313|EMBL:ENU33764.1, ECO:0000313|Proteomes:UP000018426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 1103 {ECO:0000313|EMBL:ENU33764.1,
RC ECO:0000313|Proteomes:UP000018426};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter parvus NIPH 1103.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENU33764.1}.
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DR EMBL; APOL01000021; ENU33764.1; -; Genomic_DNA.
DR RefSeq; WP_004678400.1; NZ_KB849226.1.
DR AlphaFoldDB; N8RJP0; -.
DR STRING; 134533.GCA_001485085_00446; -.
DR PATRIC; fig|1217671.3.peg.1239; -.
DR HOGENOM; CLU_013049_4_1_6; -.
DR Proteomes; UP000018426; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
FT DOMAIN 12..181
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 200..536
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 576 AA; 65874 MW; 56B763321A35C011 CRC64;
MNSLEQKFLN DLDDKLWKAA DKLRSSLDAA NYKHIVLGLI FLKYVSDAFD ERQSELKDLF
AQADDHNIYY MPRDQYDTEE EYQQAIADEL EIIDYYQEKN VFWVPKAARW TTLQNTAALA
IGSIIWQDEH GQDVKLRSIS WLVDNAFDEI EKANPKLKGI LNRIGQYQLD NDKLLDLINT
FSDTSFTKPE YNGEKLSLHS KDILGHVYEY FLGQFALAEG KQGGQYYTPK SIVTLIVEML
QPYKGRVYDP AMGSGGFFVS SEKFIEQHAQ EKHYKASEQK KHISIYGQES NPTTWKLAAM
NMAIRGIDFN FGKKNADTFL DDQHPDLRAD FVMANPPFNI KDWWHASLES DVRWKYGTPP
QGNANFAWMQ HMLHHLSPTG SMALLLANGS MSSNTNNEGE IRKNLIEADL VECIVALPGQ
LFTNTQIPAC IWFLTKDKKN GLSLDKKKAN REGKTLFIDA RNLGYMKDRV LRDFTDADIA
KITNALHAWQ QGENFEGEAY QDEKGFCFSA ELKDIQKHDY VLTPGRYVGA VEQEDDGEPF
AEKMARLTGQ LKQQFAESAV LESEIKKNLK GLGYEF
//
