ID N8VL93_9GAMM Unreviewed; 727 AA.
AC N8VL93;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Tyrosine-protein kinase ptk {ECO:0008006|Google:ProtNLM};
GN ORFNames=F969_00379 {ECO:0000313|EMBL:ENV00657.1};
OS Acinetobacter variabilis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=70346 {ECO:0000313|EMBL:ENV00657.1, ECO:0000313|Proteomes:UP000013070};
RN [1] {ECO:0000313|EMBL:ENV00657.1, ECO:0000313|Proteomes:UP000013070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 899 {ECO:0000313|EMBL:ENV00657.1,
RC ECO:0000313|Proteomes:UP000013070};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. NIPH 899.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENV00657.1}.
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DR EMBL; APPE01000026; ENV00657.1; -; Genomic_DNA.
DR RefSeq; WP_004780452.1; NZ_KB849397.1.
DR AlphaFoldDB; N8VL93; -.
DR PATRIC; fig|1217710.3.peg.357; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3206; Bacteria.
DR HOGENOM; CLU_009912_0_0_6; -.
DR Proteomes; UP000013070; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..100
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 378..458
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 544..692
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 279..306
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 727 AA; 81885 MW; D37838B16E44DA9E CRC64;
MNKNNNTDNM IDLKGVFFSL LAQWKLILLC GLLSLIVVLL YIRTAAINYK VDAIVQVEES
RGSSAALLGS LSSIVSQMSS SNAEIEVLKS RTILESVIDR LNLDLHIAST EDSFINRLIQ
GRTSQTEYQT KTVRFKDGQK SFDIRQFEVP VAYLDKNLLL KFQQQSFSLI NPLTEEIVFQ
GALNQPVEAK AAQGDWKIAI FTQDNLDNSY QVKKLSLPAA IDSILANYTI TEKGDLSGVL
QLRYQGQDKQ HITKVLNTIL AVYSQHNITR RSTDTARTLA FLDEQLPDLR KQLDDAESAF
NRFRQKYNTV DITRESELYL NQSVNLESQR ALLEQRQAEI GAKYAAAHPA MREITAQLRV
VNGKIRELNS TLKNIPEIQR QYLQLSRDVE VKQQLYTNLV NSYQQLRVAK AGESGNVHII
DTALEPVDQI QQKQPLILFL TFCFGIFLGI LVALFRNMLR SGVKDSSQIE YQLDLPVYAN
IAHSTVQKPG LKLLKKKKMP FLLALKHSDD MAVESLRSIR TASHFALTQA KNNIMMISGP
APKVGKSFVA SNLAVIMAEK NKRVLIIDAD LRRGHIHKYF NLDNQYGLTE YLNEHVSLDK
VVQTTNVPNL NVISCGENAT NPAELLNSER FQELLQKLIP YYDHIIIDTP PVLAVTDAII
VSRYVGLNLV VARYAKTQMK ELALTVNRFK QAGSTVNGLI LNDIQRSAGG SYSYDYTYSY
KPKAKTS
//
