ID N9MLZ0_9GAMM Unreviewed; 727 AA.
AC N9MLZ0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Tyrosine-protein kinase ptk {ECO:0000313|EMBL:ENW94375.1};
GN ORFNames=F904_01301 {ECO:0000313|EMBL:ENW94375.1};
OS Acinetobacter dispersus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=70348 {ECO:0000313|EMBL:ENW94375.1, ECO:0000313|Proteomes:UP000013261};
RN [1] {ECO:0000313|EMBL:ENW94375.1, ECO:0000313|Proteomes:UP000013261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANC 4105 {ECO:0000313|EMBL:ENW94375.1,
RC ECO:0000313|Proteomes:UP000013261};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. ANC 4105.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENW94375.1}.
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DR EMBL; APRL01000010; ENW94375.1; -; Genomic_DNA.
DR RefSeq; WP_005186431.1; NZ_KB850049.1.
DR AlphaFoldDB; N9MLZ0; -.
DR PATRIC; fig|1217703.3.peg.1250; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3206; Bacteria.
DR HOGENOM; CLU_009912_0_0_6; -.
DR OrthoDB; 9775724at2; -.
DR Proteomes; UP000013261; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ENW94375.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 16..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..101
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 377..458
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 535..690
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 279..306
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 727 AA; 81719 MW; D746D424905017FA CRC64;
MSQNTNTEDT IDLKELFFAL IAQWKLIALC IILSLVLALL YLRATPDTYS VDALVQVEDS
KGASAALLGD LSQMIEQKSP AQAEIEILKS RLVLGSAIKD LHLDIQVSST ENTLAHRLLN
DSDYKTNYTK NSVIFKNGTK SFEIRQFDVP AYYLDKNFLL RFNRQSLTLT DPITEEVVLT
APLNQLNQIM GPKGRWKVAI FTKDQLDEKY NIKKQSTPAA VDTLSSNYSV AERGKLTGIL
GLTYQGQDKE HITKVLNAIL VTYSAQNIER RSAESAQTLK FLDEQLPELK KQLDDAERIF
NKFRQQYNTV DVTKESELYL TQSITLETKK IELQQQQADL AAKYTAEHPA IREINAQITS
LNKQIAALNN TLKQLPDVQR QYLQLYREVE VKTQLYTALL NSYQQLRIAK AGEIGNVRIV
DTAIQPVKPI KPQKLLILIL SIFAGSLTGT VIALLRNMLR TGVKDSTQIE SEFDLPVYAT
VPRSPVQETR ISILKKKKSI PILAVKHNDD IAVESLRSIR TAIHFALANA KNNIIMIAGP
SPEVGKSFIS TNLATIFAQS NKKVLIIDAD MRRGYLHKYF NVEIKPGLSE YLSHQADLNQ
VIHQTEISGL SVITRGKNPT NPSEMLGSEQ FKSLLEQLSQ QYDHIIIDTP PILAVTDGII
ISQYSGVNLI IARYAKSQMK ELELSLNRFE QANVKVNGFI LNDIQRSSAG YGYGYNYSYA
YKAHKDD
//
