ID N9Q1U3_9GAMM Unreviewed; 495 AA.
AC N9Q1U3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Nicotinamide phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00035036};
DE EC=2.4.2.12 {ECO:0000256|ARBA:ARBA00035024};
GN ORFNames=F888_01214 {ECO:0000313|EMBL:ENX39728.1};
OS Acinetobacter courvalinii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=280147 {ECO:0000313|EMBL:ENX39728.1, ECO:0000313|Proteomes:UP000013200};
RN [1] {ECO:0000313|EMBL:ENX39728.1, ECO:0000313|Proteomes:UP000013200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 3623 {ECO:0000313|EMBL:ENX39728.1,
RC ECO:0000313|Proteomes:UP000013200};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. NIPH 3623.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-
CC ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and
CC nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00035007}.
CC -!- SIMILARITY: Belongs to the NAPRTase family.
CC {ECO:0000256|ARBA:ARBA00010897}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENX39728.1}.
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DR EMBL; APSA01000004; ENX39728.1; -; Genomic_DNA.
DR RefSeq; WP_005283570.1; NZ_VZOE01000019.1.
DR AlphaFoldDB; N9Q1U3; -.
DR STRING; 1217698.F888_01214; -.
DR GeneID; 80105389; -.
DR PATRIC; fig|1217698.3.peg.1166; -.
DR HOGENOM; CLU_012550_2_0_6; -.
DR Proteomes; UP000013200; Unassembled WGS sequence.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR CDD; cd01569; PBEF_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041529; DUF5598.
DR InterPro; IPR041525; N/Namide_PRibTrfase.
DR InterPro; IPR016471; Nicotinamide_PRibTrfase.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR PANTHER; PTHR43816; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43816:SF1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF18127; NAMPT_N; 1.
DR Pfam; PF04095; NAPRTase; 1.
DR PIRSF; PIRSF005943; NMPRT; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..64
FT /note="Nicotinamide phosphoribosyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18127"
FT DOMAIN 189..478
FT /note="Nicotinate/nicotinamide phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04095"
SQ SEQUENCE 495 AA; 55344 MW; 9084D049C96D5F0A CRC64;
MSIKINPLNA IDFYKADHRR QYPVGTEYVY ANFTPRSSRL AKMLPDFDDK IVFFGLQGFI
KHFLIETWNE GFFNQPKAKV VAAYQRRMDN ALGEGAVPVK HIEALHDLGY LPLKIKALPE
GSRVNIKVPV LTIINTDPNF FWLTNYIETV LSAELWKSCT TASIAYEYKR LLTQYAEKTG
APLDFVPVQG HDFSSRGMSG IYDAAQSGVG HLTSFIGTDS VASIDYAEEY YNATGIVGVS
VPATEHSVMC MGSEESEIET FRRLICELYP AGVVSIVSDT WDFWRVITEF SVELKTEILQ
RKPNTLGLAK VVFRPDSGDP VKIICGDPEA ERDSPAYKGA VQCLWEIFGG TKTAQGYKVL
NERVGLIYGD SITLERAQNI LKGLQAKGFA SNNLVFGIGS YTYNYLTRDS FGFAVKATWG
QVNGVGRELF KDPVTDSGVK KSAKGLLRVE QTENGFELFD QQNFEQENMG ALQTVFENGQ
LLRECSLDQI RERLV
//
