ID N9UXA5_9SPHN Unreviewed; 1155 AA.
AC N9UXA5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=EBMC1_03180 {ECO:0000313|EMBL:ENY83070.1};
OS Sphingopyxis sp. MC1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingopyxis.
OX NCBI_TaxID=1174684 {ECO:0000313|EMBL:ENY83070.1, ECO:0000313|Proteomes:UP000013072};
RN [1] {ECO:0000313|EMBL:ENY83070.1, ECO:0000313|Proteomes:UP000013072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC1 {ECO:0000313|EMBL:ENY83070.1,
RC ECO:0000313|Proteomes:UP000013072};
RA Lolas I.B., Kjeldal H., Almeida B., Le-Quy V., Gough H.L., Nielsen J.L.;
RT "Differential expression analysis of membrane associated proteins from
RT triclosan-degrading sphingopyxis.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENY83070.1}.
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DR EMBL; AOUN01000002; ENY83070.1; -; Genomic_DNA.
DR RefSeq; WP_003040461.1; NZ_AOUN01000002.1.
DR AlphaFoldDB; N9UXA5; -.
DR PATRIC; fig|1174684.3.peg.637; -.
DR eggNOG; COG1074; Bacteria.
DR Proteomes; UP000013072; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000013072}.
FT DOMAIN 7..484
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 521..787
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 930..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..948
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 28..35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1155 AA; 123304 MW; F272D61E258B3834 CRC64;
MSKSAGLATL DPRQGAAADP ESHVWLGASA GTGKTQVLSA RVLRLMLDGV SPQAILCITF
TKAGAAEMAH RIHERLATWV RMSDGDLRLD LHALGLDWER PGLMTRARSL FATVIDSPGG
AIRVQTIHSF CQTLLASFPI EAKLLPGFRA IEEDEAAALK RQILGDLLEH DPDREALRAV
AAMLSRRLGQ ESALAFLSSC AAVFGGPRAA LPPAAHDLRA AFDLPGGDPD AWLAGEIAGG
AISDADIKAV ATSGAAWGTK TGEACSDKMV GWLIAEASAR AAMLDELLGC FLTGKGELRA
DFAGDKGRMT DCADSAVRIV DAAGRLCATA TAMRVADDLA AGWKLGARFA EAYALAKRDA
GLADFDDLIT LAGTLLRVSS FGEWVRFKLD QRTDHILVDE AQDTNMRQWG IVLSLAEEFF
AGVSAKDDRL RTLFTVGDRK QAIFGFQGTE PKAFATARDM FHALGEMGGQ PFRQVDLVSN
YRSTPAVLDV VDRWLGDGGT IAMGLDGEEP PHRPFRSAQA GQVELWAPLP VGKAIDAAAA
EDGGDEGDGS APASDPASMR LAKAIAGEVQ DWIANGKDGR PVAPGDIMIL VRRRRDLAAR
IVARLQALHV PVAGVDRFAL TQPLAVQDLI AAMRFAVQPL DDLNLAALLV SPLLGWTQDD
LYARTAKRGR AAIWEHLRAH EDAMPPATMA ALRALLGMAD FTTPFRFLET ILSGPIDGRR
KLYARLGREA RDPIDELLSQ ALAFEARETV SLLGFLTRIA GSSADIKRQT EARSDVVRVM
TVHGSKGLQA PIVILADATD DAAIGHRPFT VDVAAWEKLP VFAMPADERQ GALAQAYQDA
ADAAAQEHWR LFYVAMTRAE EMLIVAGVTK KPDLSVPETS WHSAAAVALE GLGCDWEDAG
PLWGRRRVHR VNDGKWARRD AAVRAAPPPL ALPAWTHTPA PEEARPPRPL APSALGEDDV
AVPPQGSARV AAVTRGLLLH ALFERLPPVA TDRRRAAALR WLAAQAPMLD DAARMAMADE
VLAILDDPAH AALFGPDSLA EVPLSAVVDG MVVAGIVDRL RVTDDAVTVI DYKTGRRIPG
SASDVAPAYL RQMAAYRDAL AVIFPGRRVE TALLYTAGPR LIALDDAVLA PHKPGLLAAK
ANLPPPPLEP DAPTS
//
