ID N9W269_9SPHN Unreviewed; 635 AA.
AC N9W269;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:ENY81602.1};
GN ORFNames=EBMC1_08766 {ECO:0000313|EMBL:ENY81602.1};
OS Sphingopyxis sp. MC1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingopyxis.
OX NCBI_TaxID=1174684 {ECO:0000313|EMBL:ENY81602.1, ECO:0000313|Proteomes:UP000013072};
RN [1] {ECO:0000313|EMBL:ENY81602.1, ECO:0000313|Proteomes:UP000013072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC1 {ECO:0000313|EMBL:ENY81602.1,
RC ECO:0000313|Proteomes:UP000013072};
RA Lolas I.B., Kjeldal H., Almeida B., Le-Quy V., Gough H.L., Nielsen J.L.;
RT "Differential expression analysis of membrane associated proteins from
RT triclosan-degrading sphingopyxis.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENY81602.1}.
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DR EMBL; AOUN01000005; ENY81602.1; -; Genomic_DNA.
DR RefSeq; WP_003043752.1; NZ_AOUN01000005.1.
DR AlphaFoldDB; N9W269; -.
DR PATRIC; fig|1174684.3.peg.1770; -.
DR eggNOG; COG0768; Bacteria.
DR Proteomes; UP000013072; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000013072};
KW Transferase {ECO:0000313|EMBL:ENY81602.1}.
FT DOMAIN 65..236
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 269..587
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 635 AA; 69047 MW; 12C45FCF9530008D CRC64;
MSRKKSPPIT EAWRGLTFTR RTLVVGGGQI AVGAALATRM GYISIIDNDR YVLESESNRV
NLTLIPPRRG WIVDRHGKAL ANNRVSLRID IIPDRMHSKE LVLGQLRTLL QLDGDAMARI
ERDLKAASGF QPVAVAEDVT EQQYASILVR LPDLPGIAPT RGFARNYPTG AAVGHLIGYV
GAPTAEEYEK VKDPLFITPG FKTGKDGLEK YFEELLRGKA GAKRVEVTAR GKVVRDLSTQ
PDTQGKTVHL TIDADLQEYA ARRMGPESGA AVVIDCLNGD ILAFVSMPSF DPNSFSDGIS
NAEYGWLRAD DHQPLINKAT RGLYPPGSTL KPMAAIAAIE HGMDPSERHT CIGGYRLGNR
FFRCLGTHGS VDMPTAIMKS CNSYFYWVAD RLGYDAIAPT AKMMGLGEEF QLAGSNQRYG
TIPDSAWKMK KYGQPWSASD SLNAVIGQGY VSVNPLQLAV MASRIASGRK LYPRLVSRQF
SNEPLPFSAE AFATAREGMN RVVNAPGGTA GRSRLPLDGI QMAGKTGTAQ VRGLNTGNGK
GGTWKFRDHG LFICFAPVEN PRYAASVIIE HGMGGSRAAA PVAKDIFTFL YDREKAMEAL
TAFEAGWGGT IKERMDRDYA AWKAGIARPD PGLAQ
//
