ID N9WDS8_9CLOT Unreviewed; 744 AA.
AC N9WDS8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=HMPREF1092_02160 {ECO:0000313|EMBL:ENZ00995.1};
OS Clostridium thermobutyricum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=29372 {ECO:0000313|EMBL:ENZ00995.1, ECO:0000313|Proteomes:UP000013097};
RN [1] {ECO:0000313|EMBL:ENZ00995.1, ECO:0000313|Proteomes:UP000013097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=209318 {ECO:0000313|EMBL:ENZ00995.1,
RC ECO:0000313|Proteomes:UP000013097};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium colicanis 209318.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENZ00995.1}.
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DR EMBL; AGYT01000010; ENZ00995.1; -; Genomic_DNA.
DR RefSeq; WP_002598652.1; NZ_KB850956.1.
DR AlphaFoldDB; N9WDS8; -.
DR PATRIC; fig|999411.4.peg.2127; -.
DR eggNOG; COG0507; Bacteria.
DR HOGENOM; CLU_007524_0_1_9; -.
DR Proteomes; UP000013097; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788:SF6; DNA HELICASE B; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00278; HhH1; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:ENZ00995.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Reference proteome {ECO:0000313|Proteomes:UP000013097}.
FT DOMAIN 83..102
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 116..135
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 180..199
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 332..564
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 343..347
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 744 AA; 84239 MW; A13D0D37E16FE649 CRC64;
METIVGLVEG IVFKSEDSGY TVLKVNVNNQ TITATGAVPF AKEGQSVKLT GEWIIHKQFG
KQFKIEEFEE ILPTSKDGIE RYLSAGVIYG IGPVTAKRIV EYFGEETLDI LDNNIERLKE
VEGIGDKKFK IIYDSYQEQK GLRDIILFFT EYGLSNNQCI KLYKKYGDRA KDLIKENPYR
LCKDISGIGF KTADKIAMNM GVISESPYRI KSGIDYVLGR FCANGNTYMP KERLIEEASE
TLVVKKDLIE ENIYNLYLEK GIIVEKINGV EAVFSLPFYY SEIGITKKII ELGIENFQTI
NTDVEHEVKM FERSQGITFA PSQKEAILNA FSEGIEIITG GPGTGKTTII KCIIDIYEKN
GLKVLLAAPT GRAAKRMSES TGREAKTIHR LLEMGVSDEE GEKTTFLKGD GEPLEGDVII
LDEASMIDVN LMNSLLKAIK LGTRLIIVGD VDQLPSVGAG NVLNDLINSE FIKVIRLREI
FRQGAESLIT VNAHRINNGE MPHLNKKGND FYFIRSENSE DILNTIIDLV NRRLPKFNKD
WDKLRDIQVL TPMRKGVLGV ENMNEKIQEV LNPKENYKKE KKVRETTFRE GDKVMQTKNN
YSLKWTRVSG EGEEEGVGVF NGDMGFIQTI NEEEKTIVVI FDDERRVKYD YVYVDELELA
YSITIHKSQG SEFKVVIIPA FMGSPLLMNK NLLYTGITRA KKLVVVVGMP KALNYMVKNT
KSMERYSALE HKIKEITQHE FVEE
//