GenomeNet

Database: UniProt
Entry: N9WDS8_9CLOT
LinkDB: N9WDS8_9CLOT
Original site: N9WDS8_9CLOT 
ID   N9WDS8_9CLOT            Unreviewed;       744 AA.
AC   N9WDS8;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE            EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN   Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN   ORFNames=HMPREF1092_02160 {ECO:0000313|EMBL:ENZ00995.1};
OS   Clostridium thermobutyricum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=29372 {ECO:0000313|EMBL:ENZ00995.1, ECO:0000313|Proteomes:UP000013097};
RN   [1] {ECO:0000313|EMBL:ENZ00995.1, ECO:0000313|Proteomes:UP000013097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=209318 {ECO:0000313|EMBL:ENZ00995.1,
RC   ECO:0000313|Proteomes:UP000013097};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA   Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Clostridium colicanis 209318.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC       Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC       least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC       Rule:MF_01488}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC   -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01488}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ENZ00995.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGYT01000010; ENZ00995.1; -; Genomic_DNA.
DR   RefSeq; WP_002598652.1; NZ_KB850956.1.
DR   AlphaFoldDB; N9WDS8; -.
DR   PATRIC; fig|999411.4.peg.2127; -.
DR   eggNOG; COG0507; Bacteria.
DR   HOGENOM; CLU_007524_0_1_9; -.
DR   Proteomes; UP000013097; Unassembled WGS sequence.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd17933; DEXSc_RecD-like; 1.
DR   CDD; cd18809; SF1_C_RecD; 1.
DR   Gene3D; 1.10.10.2220; -; 1.
DR   Gene3D; 2.30.30.940; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   HAMAP; MF_01488; RecD_like; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR006345; DNA_helicase_RecD-like.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR029493; RecD-like_HHH.
DR   InterPro; IPR041451; RecD-like_SH13.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   NCBIfam; TIGR01448; recD_rel; 1.
DR   PANTHER; PTHR43788:SF6; DNA HELICASE B; 1.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13245; AAA_19; 1.
DR   Pfam; PF14490; HHH_4; 1.
DR   Pfam; PF14520; HHH_5; 1.
DR   Pfam; PF18335; SH3_13; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00278; HhH1; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:ENZ00995.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013097}.
FT   DOMAIN          83..102
FT                   /note="Helix-hairpin-helix DNA-binding motif class 1"
FT                   /evidence="ECO:0000259|SMART:SM00278"
FT   DOMAIN          116..135
FT                   /note="Helix-hairpin-helix DNA-binding motif class 1"
FT                   /evidence="ECO:0000259|SMART:SM00278"
FT   DOMAIN          180..199
FT                   /note="Helix-hairpin-helix DNA-binding motif class 1"
FT                   /evidence="ECO:0000259|SMART:SM00278"
FT   DOMAIN          332..564
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   BINDING         343..347
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ   SEQUENCE   744 AA;  84239 MW;  A13D0D37E16FE649 CRC64;
     METIVGLVEG IVFKSEDSGY TVLKVNVNNQ TITATGAVPF AKEGQSVKLT GEWIIHKQFG
     KQFKIEEFEE ILPTSKDGIE RYLSAGVIYG IGPVTAKRIV EYFGEETLDI LDNNIERLKE
     VEGIGDKKFK IIYDSYQEQK GLRDIILFFT EYGLSNNQCI KLYKKYGDRA KDLIKENPYR
     LCKDISGIGF KTADKIAMNM GVISESPYRI KSGIDYVLGR FCANGNTYMP KERLIEEASE
     TLVVKKDLIE ENIYNLYLEK GIIVEKINGV EAVFSLPFYY SEIGITKKII ELGIENFQTI
     NTDVEHEVKM FERSQGITFA PSQKEAILNA FSEGIEIITG GPGTGKTTII KCIIDIYEKN
     GLKVLLAAPT GRAAKRMSES TGREAKTIHR LLEMGVSDEE GEKTTFLKGD GEPLEGDVII
     LDEASMIDVN LMNSLLKAIK LGTRLIIVGD VDQLPSVGAG NVLNDLINSE FIKVIRLREI
     FRQGAESLIT VNAHRINNGE MPHLNKKGND FYFIRSENSE DILNTIIDLV NRRLPKFNKD
     WDKLRDIQVL TPMRKGVLGV ENMNEKIQEV LNPKENYKKE KKVRETTFRE GDKVMQTKNN
     YSLKWTRVSG EGEEEGVGVF NGDMGFIQTI NEEEKTIVVI FDDERRVKYD YVYVDELELA
     YSITIHKSQG SEFKVVIIPA FMGSPLLMNK NLLYTGITRA KKLVVVVGMP KALNYMVKNT
     KSMERYSALE HKIKEITQHE FVEE
//
DBGET integrated database retrieval system