ID N9WYK1_CLOIN Unreviewed; 843 AA.
AC N9WYK1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=HMPREF1094_00997 {ECO:0000313|EMBL:ENY88546.1};
OS [Clostridium] innocuum 2959.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Coprobacillaceae; Thomasclavelia.
OX NCBI_TaxID=999413 {ECO:0000313|EMBL:ENY88546.1, ECO:0000313|Proteomes:UP000013051};
RN [1] {ECO:0000313|EMBL:ENY88546.1, ECO:0000313|Proteomes:UP000013051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2959 {ECO:0000313|EMBL:ENY88546.1,
RC ECO:0000313|Proteomes:UP000013051};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium innocuum 2959.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENY88546.1}.
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DR EMBL; AGYV01000001; ENY88546.1; -; Genomic_DNA.
DR RefSeq; WP_002606694.1; NZ_KB850943.1.
DR AlphaFoldDB; N9WYK1; -.
DR GeneID; 61923889; -.
DR PATRIC; fig|999413.4.peg.1042; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_9; -.
DR Proteomes; UP000013051; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000013051}.
FT DOMAIN 680..696
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 606..613
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 843 AA; 96867 MW; 9D2856421DCC650F CRC64;
MTKKATYTPM MKHYLELKEQ HEDAIIFYRL GDFYEMFFED AKTASSELDL VLTGRNAGVE
ERVPMCGIPH HAAKGYIQRL IQKGYKVAIV EQLEDPALAK GLVKRDVIKI VTPGTIMDEV
SDEKTTVYIA SLHDFKFGLA VILCEMTTGE LRAQLIDKHV MAIQKVLLGN NVREIVIQEK
FDKKIVKMIE EMQTITVSYH NDNALKEEYR HLLNGIEDDR VETAFGVLTN YLDETQKRNM
AHLNAVEMVY ENDFLQMDFS TKQNLELTSS LRSNSRSQTL WSFLDKCRSS MGSRLLKKWI
EYPLVDTAMI NRRLNAVEYL NDNFITKDEL REHLGFVYDM ERLSARVAYG SANPRDILRL
IKTLEHTPQI FELFHDCSAY EEFQSIDPCR ELYDMIEGAI IDNPPLTLKD GGVFVEGYNE
ELDQVREIGK NGKNWILELE NKERERTGVK SLKIGYNRVF GYYIEVTKTN LDSIKDEFGY
VRKQTLTNAE RFITQELKDK EDAIVHAQER SIRLEAELFN HLLNQIKVYL PKLHDLSHAL
ATIDALYALA EISSENGYTR PQFHTGHSIH MKEARHPILD RMMKTTRYVS NDLEMGEDND
ILMITGPNMG GKSTYMRQTV LLVIMAQIGC FVPAKKAEMP IFDQIFTRIG ASDDIMSGQS
TFMVEMIEAN NALQNATANS LILFDEIGRG TSTYDGMALA QAMIEYIMRN IKAKTLFSTH
YHELTEMAEK NAGIRNVHVD VHEEDDKVTF LYRVLDGKAD KSYGINVARL AHLPSSVLER
AKQILDNLEL QPNMVKEVKP PLVIEKENPQ HMQIINQVKQ VDVNKMTPME AMQFLYELKE
KMS
//
