ID N9Y0C7_9CLOT Unreviewed; 857 AA.
AC N9Y0C7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF1092_00828 {ECO:0000313|EMBL:ENZ01594.1};
OS Clostridium thermobutyricum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=29372 {ECO:0000313|EMBL:ENZ01594.1, ECO:0000313|Proteomes:UP000013097};
RN [1] {ECO:0000313|EMBL:ENZ01594.1, ECO:0000313|Proteomes:UP000013097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=209318 {ECO:0000313|EMBL:ENZ01594.1,
RC ECO:0000313|Proteomes:UP000013097};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium colicanis 209318.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENZ01594.1}.
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DR EMBL; AGYT01000008; ENZ01594.1; -; Genomic_DNA.
DR RefSeq; WP_002597330.1; NZ_KB850956.1.
DR AlphaFoldDB; N9Y0C7; -.
DR PATRIC; fig|999411.4.peg.803; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_10_9; -.
DR Proteomes; UP000013097; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Exonuclease {ECO:0000313|EMBL:ENZ01594.1};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nuclease {ECO:0000313|EMBL:ENZ01594.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000013097}.
FT DOMAIN 1..311
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 318..791
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 857 AA; 100590 MW; 0CB1806343BF143D CRC64;
MEFNENQLKV INEFNRNIYL TAPAGTGKTM VLSERICKML DKGIDAKKIL CITFTNKACM
ELKERILDKT KGRGKDVIVK TFHSFCLSII KEFAKKKTDF FYDFTVFDQN DTKELIKRIS
EPRNLDPIRL QKCINFIKEI RIEKDIFTES ENKDLLRVLE IIKNSREKRI KLSDLVTYKE
GYEFIKDSNL ENLILNEGNV FARVYNTLLA TNRGIDFNDI LSTAKIIFRN KEIVEEYRER
FKYICVDEMQ DTGLIEYGVI RKIFEGNNVL LCGDSFQTIY SFRGSKPLEI LYDFRKFNPI
EISFNENYRS TKKINNLSKT FLKNAFKDKF NKIYSNGLES FSKEDGDDIK ILSFENPKEE
SRGIIKICKE LQEKGADLKS TCILTRNNYI NTDISMQIRE LQEKNLNFEF ALVDDFNFFK
RVEVKDVIGF FKVIINEHDT VNLERILKKL NTKVSKDTIS SIMDSKTHKK LRIKINDYVS
EYSEKGEYYT TLIEEFKNSN IVVFDVESTG VNVTEDEIIQ IAAIKLDSNG NEIDKFERFI
KPSKTVGSSY FVHNFSDEYL KEVGEEKEIV FKDFLDYIDG TVIVGHNVNY DISIFSSELK
RARMKKMNLK GVYDTLEIYR RFYSQLPNHK LEYLSKFVGT KTRPSHNALD DIRATGEILT
IALNEKIIPF SEERKNIINK DFDKFRYFRE SLKEIRKNSY ELRSYEMIDY LLEKFNFFGS
YSNETKEIKK ENISKLREVL KIVDEKEKIP RDSIIESINL TGLSNGDLEE ILVNKNGKIR
IPILTIHQAK GLEFENIILS GLQEGTFPNK KGDIEEEKRL FYVGLTRGKR RIFLTYSMKN
KWNKRVDRSY FIDLLSE
//