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Database: UniProt
Entry: N9Y0C7_9CLOT
LinkDB: N9Y0C7_9CLOT
Original site: N9Y0C7_9CLOT 
ID   N9Y0C7_9CLOT            Unreviewed;       857 AA.
AC   N9Y0C7;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HMPREF1092_00828 {ECO:0000313|EMBL:ENZ01594.1};
OS   Clostridium thermobutyricum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=29372 {ECO:0000313|EMBL:ENZ01594.1, ECO:0000313|Proteomes:UP000013097};
RN   [1] {ECO:0000313|EMBL:ENZ01594.1, ECO:0000313|Proteomes:UP000013097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=209318 {ECO:0000313|EMBL:ENZ01594.1,
RC   ECO:0000313|Proteomes:UP000013097};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA   Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Clostridium colicanis 209318.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ENZ01594.1}.
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DR   EMBL; AGYT01000008; ENZ01594.1; -; Genomic_DNA.
DR   RefSeq; WP_002597330.1; NZ_KB850956.1.
DR   AlphaFoldDB; N9Y0C7; -.
DR   PATRIC; fig|999411.4.peg.803; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_5_10_9; -.
DR   Proteomes; UP000013097; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd06127; DEDDh; 1.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; TIGR00573; dnaq; 1.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Exonuclease {ECO:0000313|EMBL:ENZ01594.1};
KW   Helicase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Nuclease {ECO:0000313|EMBL:ENZ01594.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000013097}.
FT   DOMAIN          1..311
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          318..791
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         22..29
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   857 AA;  100590 MW;  0CB1806343BF143D CRC64;
     MEFNENQLKV INEFNRNIYL TAPAGTGKTM VLSERICKML DKGIDAKKIL CITFTNKACM
     ELKERILDKT KGRGKDVIVK TFHSFCLSII KEFAKKKTDF FYDFTVFDQN DTKELIKRIS
     EPRNLDPIRL QKCINFIKEI RIEKDIFTES ENKDLLRVLE IIKNSREKRI KLSDLVTYKE
     GYEFIKDSNL ENLILNEGNV FARVYNTLLA TNRGIDFNDI LSTAKIIFRN KEIVEEYRER
     FKYICVDEMQ DTGLIEYGVI RKIFEGNNVL LCGDSFQTIY SFRGSKPLEI LYDFRKFNPI
     EISFNENYRS TKKINNLSKT FLKNAFKDKF NKIYSNGLES FSKEDGDDIK ILSFENPKEE
     SRGIIKICKE LQEKGADLKS TCILTRNNYI NTDISMQIRE LQEKNLNFEF ALVDDFNFFK
     RVEVKDVIGF FKVIINEHDT VNLERILKKL NTKVSKDTIS SIMDSKTHKK LRIKINDYVS
     EYSEKGEYYT TLIEEFKNSN IVVFDVESTG VNVTEDEIIQ IAAIKLDSNG NEIDKFERFI
     KPSKTVGSSY FVHNFSDEYL KEVGEEKEIV FKDFLDYIDG TVIVGHNVNY DISIFSSELK
     RARMKKMNLK GVYDTLEIYR RFYSQLPNHK LEYLSKFVGT KTRPSHNALD DIRATGEILT
     IALNEKIIPF SEERKNIINK DFDKFRYFRE SLKEIRKNSY ELRSYEMIDY LLEKFNFFGS
     YSNETKEIKK ENISKLREVL KIVDEKEKIP RDSIIESINL TGLSNGDLEE ILVNKNGKIR
     IPILTIHQAK GLEFENIILS GLQEGTFPNK KGDIEEEKRL FYVGLTRGKR RIFLTYSMKN
     KWNKRVDRSY FIDLLSE
//
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