GenomeNet

Database: UniProt
Entry: NAL4F_MOUSE
LinkDB: NAL4F_MOUSE
Original site: NAL4F_MOUSE 
ID   NAL4F_MOUSE             Reviewed;         959 AA.
AC   Q66X05;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   RecName: Full=NACHT, LRR and PYD domains-containing protein 4F;
DE   AltName: Full=NALP-kappa;
GN   Name=Nlrp4f; Synonyms=Nalp4f;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA   Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA   Dudekula D.B., VanBuren V., Ko M.S.H.;
RT   "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL   Hum. Mol. Genet. 13:2263-2278(2004).
RN   [2]
RP   FUNCTION, INTERACTION WITH TLE6 AND OOEP, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=31575650; DOI=10.1242/dev.183616;
RA   Qin D., Gao Z., Xiao Y., Zhang X., Ma H., Yu X., Nie X., Fan N., Wang X.,
RA   Ouyang Y., Sun Q.Y., Yi Z., Li L.;
RT   "The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic
RT   lattice formation and organelle distribution.";
RL   Development 146:0-0(2019).
CC   -!- FUNCTION: Required for cytoplasmic lattice formation, thereby modulates
CC       the distribution of organelles during oocyte maturation and zygote
CC       development (PubMed:31575650). Required for preimplantation development
CC       in female fertility (PubMed:31575650). May be involved in inflammation
CC       and recognition of cytosolic pathogen-associated molecular patterns
CC       (PAMPs) not intercepted by membrane-bound receptors (By similarity).
CC       {ECO:0000250|UniProtKB:Q96MN2, ECO:0000269|PubMed:31575650}.
CC   -!- SUBUNIT: Associates with the subcortical maternal complex (SCMC)
CC       composed of at least NLRP5, KHDC3, OOEP, and TLE6 via interaction with
CC       OOEP and TLE6. {ECO:0000269|PubMed:31575650}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31575650}.
CC       Note=Expressed and colocalizes with NLRP5 at the oocyte subcortex.
CC       {ECO:0000269|PubMed:31575650}.
CC   -!- TISSUE SPECIFICITY: Expressed in the ovaries (at protein level).
CC       {ECO:0000269|PubMed:31575650}.
CC   -!- DEVELOPMENTAL STAGE: Abundantly expressed in one-cell stage embryos
CC       with decreasing expression in the morula stage, expression in the
CC       blastocyst is considerably lower (PubMed:31575650). Expressed in the
CC       ovaries from birth, expression peaks at postnatal day 10 (P10),
CC       expression is then decreased at P17 and further decreased at P21
CC       (PubMed:31575650). {ECO:0000269|PubMed:31575650}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype, however female mice produce
CC       fewer offspring. Delay in embryo compaction and blastocyst cavitation
CC       (PubMed:31575650). Disorganization of the mitochondria in zygotes
CC       around the pronucleus and subcortical region following nuclear envelope
CC       breakdown. During oocyte maturation the endoplasmic reticulum and
CC       mitochondria are aberrantly distributed in the nucleus and cortical
CC       region at the germinal vesicle stage, in the subcortical region after
CC       germinal vesicle break down and dispersed throughout the cytoplasm at
CC       the M2 stage (PubMed:31575650). Loss of cytoplasmic lattices in oocytes
CC       (PubMed:31575650). {ECO:0000269|PubMed:31575650}.
CC   -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY596201; AAU06322.1; -; mRNA.
DR   STRING; 10090.ENSMUSP00000152151; -.
DR   iPTMnet; Q66X05; -.
DR   PhosphoSitePlus; Q66X05; -.
DR   EPD; Q66X05; -.
DR   PaxDb; 10090-ENSMUSP00000041908; -.
DR   ProteomicsDB; 286147; -.
DR   AGR; MGI:2145528; -.
DR   MGI; MGI:2145528; Nlrp4f.
DR   eggNOG; ENOG502SGVH; Eukaryota.
DR   InParanoid; Q66X05; -.
DR   PhylomeDB; Q66X05; -.
DR   ChiTaRS; Nlrp4f; mouse.
DR   PRO; PR:Q66X05; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q66X05; Protein.
DR   GO; GO:0005938; C:cell cortex; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0060090; F:molecular adaptor activity; ISO:MGI.
DR   GO; GO:0007015; P:actin filament organization; IMP:UniProtKB.
DR   GO; GO:0051656; P:establishment of organelle localization; IMP:UniProtKB.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045824; P:negative regulation of innate immune response; ISO:MGI.
DR   GO; GO:0040019; P:positive regulation of embryonic development; IMP:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF6; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 7.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Inflammatory response; Leucine-rich repeat;
KW   Nucleotide-binding; Reference proteome; Repeat.
FT   CHAIN           1..959
FT                   /note="NACHT, LRR and PYD domains-containing protein 4F"
FT                   /id="PRO_0000286338"
FT   DOMAIN          1..92
FT                   /note="Pyrin"
FT   DOMAIN          147..470
FT                   /note="NACHT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT   REPEAT          593..616
FT                   /note="LRR 1"
FT   REPEAT          632..656
FT                   /note="LRR 2"
FT   REPEAT          686..709
FT                   /note="LRR 3"
FT   REPEAT          715..738
FT                   /note="LRR 4"
FT   REPEAT          743..766
FT                   /note="LRR 5"
FT   REPEAT          812..835
FT                   /note="LRR 6"
FT   REPEAT          841..864
FT                   /note="LRR 7"
FT   REPEAT          869..892
FT                   /note="LRR 8"
FT   BINDING         153..160
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
SQ   SEQUENCE   959 AA;  110368 MW;  F498305629D9CD48 CRC64;
     MASFISDFGL IWYLRELNKK EFMKFKDFLI QEILELKLKQ VSSTKVKKAS REDLANLLLK
     CGENQAWDMT FRILQKINRK DLTERATGAI VGNPNLYRDH LKKKLTHDCP KKFNVRIQDF
     IKETFIQNDX DAFENLLISK GTERKPHMVF LKGMAGVGKT LMLKNLMLAW SKGLVFQNKF
     SYAFYFCCQD VKQLKTASLA ELISREWPSP SAPIEEILSQ PEKLLFIIDS LEGMEWDLTK
     QESELCDDCM EKQPVSTLLS SLLRRKMLPE SSLLLSTTPE TFEKMEDRIQ CTDVKTATAF
     DERSMKIYFH RLFQDRKRAQ EAFSLVRENK QLFTICQVPL LCWMVATCLK EEIEKGGDPV
     SLCRRTTSLY TTHIFSLFIP QSAQYPSKKS QDQLQGLCSL AAEGMWTDTF VFGKEALRRN
     GIFDSDIPTL LDIGMLGKIR EFENSYIFLH PSVQEVCAAI FYMLKRHVEH PSQDVKNIET
     VLFMFLKKVK TQWIFLGCFI FGLLQKSEQE KLGVFFGHRL SKNIHHKLYQ CLETLSGNAE
     LQEQIDGMRL FSCLFEMEDE AFLVKAMNCM QQINFVAKNY SDFIVAAYCL KHCSTLKKLS
     FSTENVLNEG DQSYMEELLI CWNNMCSVFV RSKDIQELRI KDTNFNEPAI RVLYESLKYP
     SFTLNKLVAN NVSFGDNHVL FELIQNSSLQ YLDLSCSFLS HNEVKLLCDI LNQAECNIEK
     LMIAHCKLSP DDCKIFGSIL MSSKSLKVLN LASNNLNQGI SSLCKALCHP HCTLEYLVPR
     SNHCIVNFLL KLSCCGITER GCQDLAEVLK NNQNLKYLHV SYNKLKDTGV MLLCDAIKHP
     NCHLKDLQLE ACEITDASNE ELCYAFMQCE TLQTLNLMGN AFEVSRMVFF PRKSELMLFI
     FLHLSRLWIT DFDNEFQAFL LSVKKKNHFL TIRGSVEADG EKKGGDSDAR TMGELSNEI
//
DBGET integrated database retrieval system