ID NFU1_DROGR Reviewed; 298 AA.
AC B4JWR9;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=NFU1 iron-sulfur cluster scaffold homolog, mitochondrial {ECO:0000250|UniProtKB:Q9UMS0};
DE Flags: Precursor;
GN ORFNames=GH17809;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1] {ECO:0000312|EMBL:EDV95195.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV95195.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Molecular scaffold for [Fe-S] cluster assembly of
CC mitochondrial iron-sulfur proteins. {ECO:0000250|UniProtKB:Q9UMS0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
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DR EMBL; CH916376; EDV95195.1; -; Genomic_DNA.
DR RefSeq; XP_001995543.1; XM_001995507.1.
DR AlphaFoldDB; B4JWR9; -.
DR SMR; B4JWR9; -.
DR STRING; 7222.B4JWR9; -.
DR EnsemblMetazoa; FBtr0153223; FBpp0151715; FBgn0125279.
DR GeneID; 6569279; -.
DR KEGG; dgr:6569279; -.
DR eggNOG; KOG2358; Eukaryota.
DR HOGENOM; CLU_060555_0_2_1; -.
DR InParanoid; B4JWR9; -.
DR OMA; AIMEHYM; -.
DR OrthoDB; 168791at2759; -.
DR PhylomeDB; B4JWR9; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR Gene3D; 3.30.300.130; Fe-S cluster assembly (FSCA); 1.
DR Gene3D; 3.30.1370.70; Scaffold protein Nfu/NifU, N-terminal domain; 1.
DR InterPro; IPR034904; FSCA_dom_sf.
DR InterPro; IPR014824; Nfu/NifU_N.
DR InterPro; IPR036498; Nfu/NifU_N_sf.
DR InterPro; IPR001075; NIF_FeS_clus_asmbl_NifU_C.
DR PANTHER; PTHR11178; IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED; 1.
DR PANTHER; PTHR11178:SF1; NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF08712; Nfu_N; 1.
DR Pfam; PF01106; NifU; 1.
DR SMART; SM00932; Nfu_N; 1.
DR SUPFAM; SSF117916; Fe-S cluster assembly (FSCA) domain-like; 1.
DR SUPFAM; SSF110836; Hypothetical protein SAV1430; 1.
PE 3: Inferred from homology;
KW Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..298
FT /note="NFU1 iron-sulfur cluster scaffold homolog,
FT mitochondrial"
FT /evidence="ECO:0000255"
FT /id="PRO_0000388697"
FT REGION 194..262
FT /note="NifU"
FT /evidence="ECO:0000255"
FT BINDING 231
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000250|UniProtKB:Q9UMS0"
FT BINDING 234
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000250|UniProtKB:Q9UMS0"
SQ SEQUENCE 298 AA; 32854 MW; 99258B53E04366C5 CRC64;
MSKLISYAAK SPLRNIRLGA TQIICQHAST DCMHMAASAS ASSSARKTYS TLAVDLTKQQ
MLLRKPLETL ALQITKRSMF IQTQDTPNPD SLKFLPGVEV LGKGNTYDFP SATAAHCSPL
AKLLFRVEGV RAVFFGSDFI TISKEENGEW GLIKPEVFAV IMDFFASGLP ILHEARPNAD
TEILEDDDET VMMIKELLDT RIRPTVQEDG GDIVFISYEK GVVKLKMQGS CSSCPSSIVT
LKNGVQNMLQ FYIPEVESVE QVFDEVDKVA NSEFERFEKS LKQKDSANPP VSIGGTQN
//
