ID NQRA_CHLTR Reviewed; 465 AA.
AC O84639;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; Synonyms=nqr1;
GN OrderedLocusNames=CT_634;
OS Chlamydia trachomatis (strain D/UW-3/Cx).
OC Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=272561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT trachomatis.";
RL Science 282:754-759(1998).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE001273; AAC68238.1; -; Genomic_DNA.
DR PIR; F71489; F71489.
DR RefSeq; NP_220151.1; NC_000117.1.
DR RefSeq; WP_009872806.1; NC_000117.1.
DR AlphaFoldDB; O84639; -.
DR SMR; O84639; -.
DR STRING; 272561.CT_634; -.
DR EnsemblBacteria; AAC68238; AAC68238; CT_634.
DR GeneID; 884415; -.
DR KEGG; ctr:CT_634; -.
DR PATRIC; fig|272561.5.peg.694; -.
DR HOGENOM; CLU_046656_0_0_0; -.
DR InParanoid; O84639; -.
DR OrthoDB; 9774536at2; -.
DR Proteomes; UP000000431; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR NCBIfam; TIGR01936; nqrA; 1.
DR PANTHER; PTHR37839; NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A; 1.
DR PANTHER; PTHR37839:SF1; NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW Translocase; Transport; Ubiquinone.
FT CHAIN 1..465
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_0000214196"
SQ SEQUENCE 465 AA; 51757 MW; 303F88DC133AB998 CRC64;
MKIVVSRGLD LSLKGAPKES GFCGKVDPTY VSVDLRPFAP LPLGVKVTPE DQVTAGSPLA
EYKLFSGVFI TSPVDGEVVE IRRGNKRALL EIVIKKKPGI SQTKFSYDLQ SLTQKDLLEV
FKKEGLFALF KQRPFDIPAL PTQSPRDVFI NLADNRPFTP SVEKHLSLFS SKEDGYYIFV
VGVQAIAKLF GLKPHIISTD RLTLPTQDLV SIAHLHTIDG PFPSGSPSTH IHHIARIRNE
RDVVFTISFQ EVLSIGHLFL KGFVLGQQIV ALAGSALPPS QRKYLITAKG ASFSDLLPKD
IFSSDEITLI SGDPLTGRLC KKEENPCLGM RDHTITLLPN PKTRESFSFL RLGWNKLTVT
RTYLSGFFKR KRVFMDMDTN MHGEKRPIID AEIYERVSAI PVPVALIIKA LETQNFEEAC
RLGLLEVAPE DFALPTFIDP SKTEMFSIVK ESLLRYAKEN VVTSS
//
