ID   NRDR_ERYLH              Reviewed;         153 AA.
AC   Q2NAS1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=ELI_05640;
OS   Erythrobacter litoralis (strain HTCC2594).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Erythrobacter/Porphyrobacter group; Erythrobacter.
OX   NCBI_TaxID=314225;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2594;
RX   PubMed=19168610; DOI=10.1128/jb.00026-09;
RA   Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.;
RT   "Complete genome sequence of Erythrobacter litoralis HTCC2594.";
RL   J. Bacteriol. 191:2419-2420(2009).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
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DR   EMBL; CP000157; ABC63220.1; -; Genomic_DNA.
DR   RefSeq; WP_011414056.1; NC_007722.1.
DR   AlphaFoldDB; Q2NAS1; -.
DR   SMR; Q2NAS1; -.
DR   STRING; 314225.ELI_05640; -.
DR   KEGG; eli:ELI_05640; -.
DR   eggNOG; COG1327; Bacteria.
DR   HOGENOM; CLU_108412_0_1_5; -.
DR   OrthoDB; 9807461at2; -.
DR   Proteomes; UP000008808; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   NCBIfam; TIGR00244; transcriptional regulator NrdR; 1.
DR   PANTHER; PTHR30455; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR   PANTHER; PTHR30455:SF2; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..153
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_1000080751"
FT   DOMAIN          49..139
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ   SEQUENCE   153 AA;  17406 MW;  3C4733F7E8BCAF22 CRC64;
     MRCPFCAHDD SQVKDSRPAE DNAAIRRRRQ CSKCGARFTT FERVQLRDVT VVKSDDKREA
     FDRSKLEQSV TLACRKRGVT QEQIDQLVSG IQRQVETAGE GEIASTRIGE MVMDGLRQID
     SVAYIRFASV YRDFSEARDF EEFASTVQEA AKD
//