ID NRIP2_HUMAN Reviewed; 281 AA.
AC Q9BQI9; A2RRE3; B4DV61;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 3.
DT 24-JAN-2024, entry version 157.
DE RecName: Full=Nuclear receptor-interacting protein 2;
GN Name=NRIP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Small intestine, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Down-regulates transcriptional activation by nuclear
CC receptors such as NR1F2. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NR1F2, RARA and THRB in a ligand-dependent
CC manner. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9BQI9; Q8N9N5: BANP; NbExp=3; IntAct=EBI-3913975, EBI-744695;
CC Q9BQI9; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-3913975, EBI-11524452;
CC Q9BQI9; Q8WUI4-6: HDAC7; NbExp=6; IntAct=EBI-3913975, EBI-12094670;
CC Q9BQI9; P36508: ZNF76; NbExp=3; IntAct=EBI-3913975, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BQI9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BQI9-2; Sequence=VSP_053930;
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DR EMBL; AL136557; CAB66492.1; -; mRNA.
DR EMBL; AK098063; BAG53573.1; -; mRNA.
DR EMBL; AK300944; BAG62573.1; -; mRNA.
DR EMBL; AC005841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471116; EAW88888.1; -; Genomic_DNA.
DR EMBL; BC036063; AAH36063.1; -; mRNA.
DR EMBL; BC131562; AAI31563.1; -; mRNA.
DR CCDS; CCDS8514.1; -. [Q9BQI9-1]
DR RefSeq; NP_113662.1; NM_031474.2. [Q9BQI9-1]
DR RefSeq; XP_005253854.1; XM_005253797.3.
DR AlphaFoldDB; Q9BQI9; -.
DR SMR; Q9BQI9; -.
DR BioGRID; 123737; 7.
DR IntAct; Q9BQI9; 6.
DR MINT; Q9BQI9; -.
DR STRING; 9606.ENSP00000337501; -.
DR MEROPS; A28.A10; -.
DR iPTMnet; Q9BQI9; -.
DR PhosphoSitePlus; Q9BQI9; -.
DR BioMuta; NRIP2; -.
DR DMDM; 251757451; -.
DR jPOST; Q9BQI9; -.
DR MassIVE; Q9BQI9; -.
DR PaxDb; 9606-ENSP00000337501; -.
DR PeptideAtlas; Q9BQI9; -.
DR ProteomicsDB; 78692; -. [Q9BQI9-1]
DR Antibodypedia; 22178; 227 antibodies from 25 providers.
DR DNASU; 83714; -.
DR Ensembl; ENST00000337508.9; ENSP00000337501.4; ENSG00000053702.15. [Q9BQI9-1]
DR GeneID; 83714; -.
DR KEGG; hsa:83714; -.
DR MANE-Select; ENST00000337508.9; ENSP00000337501.4; NM_031474.3; NP_113662.1.
DR UCSC; uc001qlc.4; human. [Q9BQI9-1]
DR AGR; HGNC:23078; -.
DR CTD; 83714; -.
DR DisGeNET; 83714; -.
DR GeneCards; NRIP2; -.
DR HGNC; HGNC:23078; NRIP2.
DR HPA; ENSG00000053702; Tissue enriched (brain).
DR neXtProt; NX_Q9BQI9; -.
DR OpenTargets; ENSG00000053702; -.
DR PharmGKB; PA134978127; -.
DR VEuPathDB; HostDB:ENSG00000053702; -.
DR eggNOG; KOG0012; Eukaryota.
DR GeneTree; ENSGT00950000182999; -.
DR HOGENOM; CLU_087166_0_0_1; -.
DR InParanoid; Q9BQI9; -.
DR OMA; PSCWKES; -.
DR OrthoDB; 5358142at2759; -.
DR PhylomeDB; Q9BQI9; -.
DR TreeFam; TF333421; -.
DR PathwayCommons; Q9BQI9; -.
DR SignaLink; Q9BQI9; -.
DR BioGRID-ORCS; 83714; 15 hits in 1152 CRISPR screens.
DR GeneWiki; NRIP2; -.
DR GenomeRNAi; 83714; -.
DR Pharos; Q9BQI9; Tdark.
DR PRO; PR:Q9BQI9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9BQI9; Protein.
DR Bgee; ENSG00000053702; Expressed in olfactory bulb and 147 other cell types or tissues.
DR ExpressionAtlas; Q9BQI9; baseline and differential.
DR Genevisible; Q9BQI9; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05480; NRIP_C; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR033821; NRIP_C.
DR InterPro; IPR019103; Peptidase_aspartic_DDI1-type.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR12917; ASPARTYL PROTEASE DDI-RELATED; 1.
DR PANTHER; PTHR12917:SF17; NUCLEAR RECEPTOR-INTERACTING PROTEIN 2; 1.
DR Pfam; PF09668; Asp_protease; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..281
FT /note="Nuclear receptor-interacting protein 2"
FT /id="PRO_0000271056"
FT REGION 18..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 244..248
FT /note="LXXLL motif"
FT COMPBIAS 18..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 81..91
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053930"
FT CONFLICT 29
FT /note="R -> K (in Ref. 2; BAG62573)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="G -> S (in Ref. 2; BAG62573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 281 AA; 31331 MW; F92A490B1E7AF7D3 CRC64;
MLFIFPLSLP WRPSCWKESC STGQRQAGRS REDSVTPPPS SPWPTPPAGA MSTKQEARRD
EGEARTRGQE AQLRDRAHLS QQRRLKQATQ FLHKDSADLL PLDSLKRLGT SKDLQPRSVI
QRRLVEGNPN WLQGEPPRMQ DLIHGQESRR KTSRTEIPAL LVNCKCQDQL LRVAVDTGTQ
YNRISAGCLS RLGLEKRVLK ASAGDLAPGP PTQVEQLELQ LGQETVVCSA QVVDAESPEF
CLGLQTLLSL KCCIDLEHGV LRLKAPFSEL PFLPLYQEPG Q
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