ID NTPTH_PYRAR Reviewed; 172 AA.
AC A4WLK1;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 01-MAY-2013, entry version 39.
DE RecName: Full=Nucleoside-triphosphatase THEP1;
DE Short=NTPase THEP1;
DE EC=3.6.1.15;
DE AltName: Full=Nucleoside triphosphate phosphohydrolase;
GN OrderedLocusNames=Pars_1717;
OS Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales;
OC Thermoproteaceae; Pyrobaculum.
OX NCBI_TaxID=340102;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13514 / JCM 11321;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C.,
RA Lowe T.M., Richardson P.;
RT "Complete sequence of Pyrobaculum arsenaticum DSM 13514.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has nucleotide phosphatase activity towards ATP, GTP,
CC CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower
CC efficiency (By similarity).
CC -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC -!- SIMILARITY: Belongs to the THEP1 NTPase family.
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DR EMBL; CP000660; ABP51268.1; -; Genomic_DNA.
DR RefSeq; YP_001153920.1; NC_009376.1.
DR ProteinModelPortal; A4WLK1; -.
DR STRING; 340102.Pars_1717; -.
DR EnsemblBacteria; ABP51268; ABP51268; Pars_1717.
DR GeneID; 5054610; -.
DR KEGG; pas:Pars_1717; -.
DR eggNOG; COG1618; -.
DR HOGENOM; HOG000006446; -.
DR KO; K06928; -.
DR OMA; MEFKSNE; -.
DR ProtClustDB; PRK13695; -.
DR BioCyc; PARS340102:GHGQ-1754-MONOMER; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:HAMAP.
DR GO; GO:0019204; F:nucleotide phosphatase activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR HAMAP; MF_00796; NTPase_1; 1; -.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR000767; Disease_R.
DR InterPro; IPR004948; Nuc-triphosphatase_THEP1.
DR Pfam; PF03266; NTPase_1; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding.
FT CHAIN 1 172 Nucleoside-triphosphatase THEP1.
FT /FTId=PRO_0000360025.
FT NP_BIND 15 22 ATP (By similarity).
FT NP_BIND 101 108 ATP (By similarity).
SQ SEQUENCE 172 AA; 18886 MW; 4AB75991C6456CFA CRC64;
MMWRERAEVR IGISGMPGVG KTTLVLKVAE LAAKKLRVCG FVTQEVRERG VRIGFDVVDI
ASGRRTPLAR VGTGEPSVGK YVVFLGACST ISEALRGTCD LLIVDEIGAM EFKCPGFGSD
LERAVYNSPK VLAVVHRNYT NLAESLGFEI LWLTRDNWST IYNQVVHRLG LA
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