ID O01545_CAEEL Unreviewed; 689 AA.
AC O01545;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 2.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=VWFA domain-containing protein {ECO:0000313|EMBL:CCD70365.1};
GN ORFNames=CELE_F31F7.2 {ECO:0000313|EMBL:CCD70365.1}, F31F7.2
GN {ECO:0000313|EMBL:CCD70365.1, ECO:0000313|WormBase:F31F7.2a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70365.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70365.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70365.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; BX284605; CCD70365.1; -; Genomic_DNA.
DR PIR; T29784; T29784.
DR RefSeq; NP_504602.1; NM_072201.3.
DR AlphaFoldDB; O01545; -.
DR SMR; O01545; -.
DR STRING; 6239.F31F7.2a.1; -.
DR PaxDb; 6239-F31F7-2; -.
DR EnsemblMetazoa; F31F7.2a.1; F31F7.2a.1; WBGene00017965.
DR GeneID; 179015; -.
DR KEGG; cel:CELE_F31F7.2; -.
DR UCSC; F31F7.2; c. elegans.
DR AGR; WB:WBGene00017965; -.
DR WormBase; F31F7.2a; CE29303; WBGene00017965; -.
DR eggNOG; ENOG502SM0K; Eukaryota.
DR HOGENOM; CLU_028558_0_0_1; -.
DR InParanoid; O01545; -.
DR OMA; APYCPCE; -.
DR OrthoDB; 2880384at2759; -.
DR Reactome; R-CEL-1442490; Collagen degradation.
DR Reactome; R-CEL-1650814; Collagen biosynthesis and modifying enzymes.
DR Reactome; R-CEL-186797; Signaling by PDGF.
DR Reactome; R-CEL-2022090; Assembly of collagen fibrils and other multimeric structures.
DR Reactome; R-CEL-419037; NCAM1 interactions.
DR Reactome; R-CEL-8948216; Collagen chain trimerization.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00017965; Expressed in larva and 2 other cell types or tissues.
DR ExpressionAtlas; O01545; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR PANTHER; PTHR22588:SF14; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..631
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 19..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 79198 MW; 42C44D9BB2D76727 CRC64;
MRALKQLYNF GDIQKKIHRH HTTPLSNRTT KQKNEKKERK KTREQQFLVA FLLYPHSQKR
HKMPHRLLLY CIVILLEVNL VIGCIWPEVD ALFILDSTPQ ITSFQHRAEI DFLRQVMSTM
KMGSSKVAMA QFTPWSRIEW SLANSTYPES KVQEAPYCPC ELETCPTTSI NALTRSTMNT
ANRKSVPDVI LVISNSYQPL IEVLPNEPLI SPTSPLHVFY VVIGSNMHVS RFEPSAHTVG
IKVTDFEHLP HLVAPLCQSV NAYIKGSSST RFGPLCWIII ASILFFAIIL TALLAYAIYS
YHEENRRLRH RVTESERQLR KQNEYFTSQL HTEMQKQITY GEKHAEEMKK QQDMMQAQFD
RQLDMAYQQG SKIQILPPFN QNPHFHDHSE HTGKERGRGK EHRRDSGIAS PRTPRDVEIQ
VTPIPSPVHN GSDGKDDATS SGTPESIESS GSDVTETTED DLEELNRRTH LPRDHPARKL
LPIDLMFLVD TSSSIGINNF DIQKNFICEI LKDVDIAPGR SRIAMIQYSQ DPSVVFGFDQ
YYSYESVRRG VMRLSYTGGA TMLSKALAFA GGIMYHEQNL KKTTKKHQYL PTPKHDRLQV
LCLVSDGYSD DNADKESVNL HDHLHVKIFA VVTRSFNKDK LAPITRFDGS VFTVHQRESV
AIWLWRQQRI WAEHYSAFIE KEKKRGSRR
//