ID O01686_CAEEL Unreviewed; 676 AA.
AC O01686;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 2.
DT 27-MAR-2024, entry version 159.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=obr-4 {ECO:0000313|EMBL:CCD61906.1,
GN ECO:0000313|WormBase:C32F10.1a};
GN ORFNames=C32F10.1 {ECO:0000313|WormBase:C32F10.1a}, CELE_C32F10.1
GN {ECO:0000313|EMBL:CCD61906.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD61906.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD61906.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD61906.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; BX284601; CCD61906.1; -; Genomic_DNA.
DR PIR; T34029; T34029.
DR RefSeq; NP_491691.1; NM_059290.5.
DR AlphaFoldDB; O01686; -.
DR SMR; O01686; -.
DR DIP; DIP-25487N; -.
DR STRING; 6239.C32F10.1a.2; -.
DR EPD; O01686; -.
DR PaxDb; 6239-C32F10-1a-2; -.
DR PeptideAtlas; O01686; -.
DR EnsemblMetazoa; C32F10.1a.1; C32F10.1a.1; WBGene00016331.
DR GeneID; 172253; -.
DR KEGG; cel:CELE_C32F10.1; -.
DR UCSC; C32F10.1a; c. elegans.
DR AGR; WB:WBGene00016331; -.
DR WormBase; C32F10.1a; CE08539; WBGene00016331; obr-4.
DR eggNOG; KOG2210; Eukaryota.
DR HOGENOM; CLU_012334_3_0_1; -.
DR InParanoid; O01686; -.
DR OMA; WPGSDEK; -.
DR OrthoDB; 1018068at2759; -.
DR PhylomeDB; O01686; -.
DR Reactome; R-CEL-192105; Synthesis of bile acids and bile salts.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00016331; Expressed in adult organism and 4 other cell types or tissues.
DR ExpressionAtlas; O01686; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IPI:WormBase.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR CDD; cd13290; PH_ORP9; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF102; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Proteomics identification {ECO:0007829|EPD:O01686,
KW ECO:0007829|PeptideAtlas:O01686};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 1..93
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 190..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 76657 MW; 8CAE8AF67FDFC0B4 CRC64;
MEGPLSKWTN MVHGWQYRWF KIENDTLLYY TSREKMLKGQ QRGQIRLTGA VVGIDGENNS
LFTITVEGKT FHMQGRDLRE RNQWVRILEN SIRASSGYAK NVSVGTTPSQ HFKQRTEEAN
EFLKTLVEKV KALEQLKSGE RAVDEKKTID SLIAASNNLT NNVKHAIIYL QMAQARLDPN
MKTEKLMFTH PDLNEKPSSR ETPGTVSDST QTSTDKPISG IQHLDHLKPQ RAESYASSDE
EEFYDADEEL IDLDNFESEK SGQESGDSNR TSDAAIMSSD EDGYDFGDSN EDFDEIYNNA
EEHDIGNVQQ DHGSVLMHLL SQVSVGMDLT KVTLPTFILE RRSLLEMYAD FFAHPDLFIA
TNGNDSAEKR MIAVVRYYLN SFYAARKSGV AKKPYNAILG ETFRCRYSVP NSSLSGKKTE
SGPWPGSDEK QLTFIAEQVS HHPPISAFYA EMPSEGISFN AHIYTKSSFL GLSIGVASIG
EGILTLHNYG DEQYTITFPS GYGRSIMSTP WFEFGGKVKV ECEKTGYRAD IEFLTKPFFG
GKPHRIQGSI CRDGAKKPVL TLRGEWNGTM YAKTQNGEEY VFVDVKAKPE VKKECVPVMQ
QGKRESRRLW RHVTAALLRN RIQTATTSKR FIEQRQRKEA KERLESGEKW TPLLFDTTDK
DGEWMYKQKF GVRKAV
//
