ID O01883_CAEEL Unreviewed; 324 AA.
AC O01883;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 2.
DT 27-MAR-2024, entry version 162.
DE SubName: Full=UnCoupling Protein (Mitochondrial substrate carrier) {ECO:0000313|EMBL:CCD68613.1};
GN Name=ucp-4 {ECO:0000313|EMBL:CCD68613.1,
GN ECO:0000313|WormBase:K07B1.3};
GN ORFNames=CELE_K07B1.3 {ECO:0000313|EMBL:CCD68613.1}, K07B1.3
GN {ECO:0000313|WormBase:K07B1.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD68613.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD68613.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68613.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; BX284605; CCD68613.1; -; Genomic_DNA.
DR PIR; T15253; T15253.
DR RefSeq; NP_505414.1; NM_073013.5.
DR AlphaFoldDB; O01883; -.
DR SMR; O01883; -.
DR STRING; 6239.K07B1.3.1; -.
DR EPD; O01883; -.
DR PaxDb; 6239-K07B1-3; -.
DR PeptideAtlas; O01883; -.
DR EnsemblMetazoa; K07B1.3.1; K07B1.3.1; WBGene00006729.
DR EnsemblMetazoa; K07B1.3.2; K07B1.3.2; WBGene00006729.
DR GeneID; 179315; -.
DR KEGG; cel:CELE_K07B1.3; -.
DR UCSC; K07B1.3; c. elegans.
DR AGR; WB:WBGene00006729; -.
DR WormBase; K07B1.3; CE28591; WBGene00006729; ucp-4.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000160098; -.
DR HOGENOM; CLU_015166_14_2_1; -.
DR InParanoid; O01883; -.
DR OMA; FPFWKAV; -.
DR OrthoDB; 5488094at2759; -.
DR PhylomeDB; O01883; -.
DR Reactome; R-CEL-167826; The fatty acid cycling model.
DR Reactome; R-CEL-167827; The proton buffering model.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00006729; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0009409; P:response to cold; IMP:WormBase.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1.
DR PANTHER; PTHR45618:SF8; MITOCHONDRIAL UNCOUPLING PROTEIN 4; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Proteomics identification {ECO:0007829|EPD:O01883,
KW ECO:0007829|PeptideAtlas:O01883};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transport {ECO:0000256|RuleBase:RU000488}.
FT REPEAT 21..107
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 121..209
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 218..318
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 324 AA; 36573 MW; DF48DB24C0F3A129 CRC64;
MSSAVTSTSD STAPGNSQTF KKIATKYFLS CTAALVAETV TYPLDITKTR LQIARNKFTK
GGMVQVTYDI IRREGAMALW TGVAPAITRH YIYTGIRMGA YEQIRLLTFN KEVEKSFPLW
KSMLCGAFSG LIAQFAASPT DLVKVQMQME GLRRLQKQPL RYTGATDCFR SLYRTQGFFG
LWIGWMPNCQ RAALLNMADI ATYDSVKHGL IDNFELKDNW LTHAVASACA GLAAAIVSLP
SDVVKTRMMD QIRHELDAKM MHKKNTHVDL YKGVVDCYIK IIKNEGFFSL YKGFLPSYIR
MAPWSLTFWV SYEEIRKWTG ASSF
//
