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Database: UniProt
Entry: O03515
LinkDB: O03515
Original site: O03515 
ID   COX1_APTAU              Reviewed;         337 AA.
AC   O03515;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   14-MAY-2014, entry version 80.
DE   RecName: Full=Cytochrome c oxidase subunit 1;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide I;
DE   Flags: Fragment;
GN   Name=MT-CO1; Synonyms=COI, COXI, MTCO1;
OS   Apteryx australis (Brown kiwi).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Palaeognathae; Apterygiformes;
OC   Apterygidae; Apteryx.
OX   NCBI_TaxID=8822;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Mantelli;
RA   Lee K., Feinstein J., Cracraft J.;
RT   "Phylogenetic relationships of the ratite birds: resolving conflicts
RT   between molecular and morphological data sets.";
RL   (In) Mindell D.P. (eds.);
RL   Avian molecular evolution and systematics, pp.1-1, Academic Press, New
RL   York (1997).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
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DR   EMBL; U76057; AAB61313.1; -; Genomic_DNA.
DR   ProteinModelPortal; O03515; -.
DR   SMR; O03515; 3-337.
DR   HOVERGEN; HBG003841; -.
DR   UniPathway; UPA00705; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.210.10; -; 1.
DR   InterPro; IPR000883; Cyt_c_Oxase_su1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR023616; Cyt_c_Oxase_su1_dom.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1   >337       Cytochrome c oxidase subunit 1.
FT                                /FTId=PRO_0000183285.
FT   TRANSMEM     18     38       Helical; (Potential).
FT   TRANSMEM     57     77       Helical; (Potential).
FT   TRANSMEM    103    123       Helical; (Potential).
FT   TRANSMEM    146    166       Helical; (Potential).
FT   TRANSMEM    184    204       Helical; (Potential).
FT   TRANSMEM    235    255       Helical; (Potential).
FT   TRANSMEM    269    289       Helical; (Potential).
FT   TRANSMEM    311    331       Helical; (Potential).
FT   METAL        62     62       Iron (heme A axial ligand) (Probable).
FT   METAL       241    241       Copper B (Probable).
FT   METAL       245    245       Copper B (Probable).
FT   METAL       291    291       Copper B (Probable).
FT   METAL       292    292       Copper B (Probable).
FT   CROSSLNK    241    245       1'-histidyl-3'-tyrosine (His-Tyr) (By
FT                                similarity).
FT   NON_TER     337    337
SQ   SEQUENCE   337 AA;  36780 MW;  BE846B9B550F77DD CRC64;
     MTFITRWLFS TNHKDIGTLY LIFGAWAGMV GTALSLLIRA ELGQPGTLLG DDQIYNVIVT
     AHAFVMIFFM VMPVMIGGFG NWLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSTIE
     AGAGTGWTVY PPLAGNLAHA GASVDLAIFS LHLAGISSIL GAINFITTAI NMKPPALSQY
     QTPLFVWSVL ITAILLLLSL PVLAAGITML LTDRNLNTTF FDPAGGGDPV LYQHLFWFFG
     HPEVYILILP GFGMISHVVT YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV
     DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDP
//
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