ID COX1_APTAU Reviewed; 337 AA.
AC O03515;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 06-MAR-2013, entry version 74.
DE RecName: Full=Cytochrome c oxidase subunit 1;
DE EC=1.9.3.1;
DE AltName: Full=Cytochrome c oxidase polypeptide I;
DE Flags: Fragment;
GN Name=MT-CO1; Synonyms=COI, COXI, MTCO1;
OS Apteryx australis (Brown kiwi).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC Palaeognathae; Apterygiformes; Apterygidae; Apteryx.
OX NCBI_TaxID=8822;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Mantelli;
RA Lee K., Feinstein J., Cracraft J.;
RT "Phylogenetic relationships of the ratite birds: resolving conflicts
RT between molecular and morphological data sets.";
RL (In) Mindell D.P. (eds.);
RL Avian molecular evolution and systematics, pp.1-1, Academic Press, New
RL York (1997).
CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC 3 form the functional core of the enzyme complex. CO I is the
CC catalytic subunit of the enzyme. Electrons originating in
CC cytochrome c are transferred via the copper A center of subunit 2
CC and heme A of subunit 1 to the bimetallic center formed by heme A3
CC and copper B.
CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC ferricytochrome c + 2 H(2)O.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
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DR EMBL; U76057; AAB61313.1; -; Genomic_DNA.
DR ProteinModelPortal; O03515; -.
DR SMR; O03515; 3-337.
DR HOVERGEN; HBG003841; -.
DR UniPathway; UPA00705; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.210.10; -; 1.
DR InterPro; IPR000883; Cyt_c_Oxase_su1.
DR InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom.
DR PANTHER; PTHR10422; PTHR10422; 1.
DR Pfam; PF00115; COX1; 1.
DR PRINTS; PR01165; CYCOXIDASEI.
DR SUPFAM; SSF81442; COX1; 1.
DR PROSITE; PS50855; COX1; 1.
DR PROSITE; PS00077; COX1_CUB; 1.
PE 3: Inferred from homology;
KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 >337 Cytochrome c oxidase subunit 1.
FT /FTId=PRO_0000183285.
FT TRANSMEM 18 38 Helical; (Potential).
FT TRANSMEM 57 77 Helical; (Potential).
FT TRANSMEM 103 123 Helical; (Potential).
FT TRANSMEM 146 166 Helical; (Potential).
FT TRANSMEM 184 204 Helical; (Potential).
FT TRANSMEM 235 255 Helical; (Potential).
FT TRANSMEM 269 289 Helical; (Potential).
FT TRANSMEM 311 331 Helical; (Potential).
FT METAL 62 62 Iron (heme A axial ligand) (Probable).
FT METAL 241 241 Copper B (Probable).
FT METAL 245 245 Copper B (Probable).
FT METAL 291 291 Copper B (Probable).
FT METAL 292 292 Copper B (Probable).
FT CROSSLNK 241 245 1'-histidyl-3'-tyrosine (His-Tyr) (By
FT similarity).
FT NON_TER 337 337
SQ SEQUENCE 337 AA; 36780 MW; BE846B9B550F77DD CRC64;
MTFITRWLFS TNHKDIGTLY LIFGAWAGMV GTALSLLIRA ELGQPGTLLG DDQIYNVIVT
AHAFVMIFFM VMPVMIGGFG NWLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSTIE
AGAGTGWTVY PPLAGNLAHA GASVDLAIFS LHLAGISSIL GAINFITTAI NMKPPALSQY
QTPLFVWSVL ITAILLLLSL PVLAAGITML LTDRNLNTTF FDPAGGGDPV LYQHLFWFFG
HPEVYILILP GFGMISHVVT YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV
DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDP
//
