ID O04849_BRANA Unreviewed; 640 AA.
AC O04849;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Acetyl-CoA carboxylase {ECO:0000313|EMBL:CAA71346.1};
DE EC=6.4.1.2 {ECO:0000313|EMBL:CAA71346.1};
DE Flags: Fragment;
OS Brassica napus (Rape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CAA71346.1};
RN [1] {ECO:0000313|EMBL:CAA71346.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9096417; DOI=10.1073/pnas.94.7.3465;
RA Schulte W., Topfer R., Stracke R., Schell J., Martini N.;
RT "Multi-functional acetyl-CoA carboxylase from Brassica napus is encoded by
RT a multi-gene family: indication for plastidic localization of at least one
RT isoform.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:3465-3470(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
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DR EMBL; Y10301; CAA71346.1; -; Genomic_DNA.
DR PIR; T07923; T07923.
DR AlphaFoldDB; O04849; -.
DR EnsemblPlants; CDX91737; CDX91737; GSBRNA2T00153243001.
DR Gramene; CDX91737; CDX91737; GSBRNA2T00153243001.
DR ExpressionAtlas; O04849; baseline.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR PANTHER; PTHR45728:SF3; ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CAA71346.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 33..540
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 186..378
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT NON_TER 640
FT /evidence="ECO:0000313|EMBL:CAA71346.1"
SQ SEQUENCE 640 AA; 70096 MW; 02E587EBA3B78E1C CRC64;
MAGSVNGYQT PGRNHVSVSE VDDFCIALGG KRPIHSILIA NNGMAAVKFI RSVRTWAYET
FGTERAILLV GMATPEDMRI NAEHIRIADQ FVEVPGGTNN NNYANVQLIV EMAEVTRVDA
VWPGWGHASE NPELPDALKA KGIIFLGPPA ASMAALGDKI GSSLIAQAAD VPTLPWSGSH
VKIPPDSSLV TIPEEIYRQA CVYTTEEAIA SCQVVGYPAM IKASWGGGGK GIRKVHNADE
VRALFKQVQG EVPGSPIFIM KVASQSRHLE VQLLCDQYGN VSALHSRDCS VQRRHQKIIE
EGPITVAPQE TIKKLEQAGR RLAKSVNYVG AATVEYLYSM DTGEYYFLEL NPRLQVEHPV
TEWIAEINLP AAQVAVGMGI PLWQIPEIRR FYGIEHGGGY DSWRKTSVLA SPFDFDKAES
IRPKGHCVAV RVTSEDPDDG FKPTSGKVQE LSFKSKPNVW AYFSVKSGGG IHEFSDSQFG
HVFAFGESRA LAIANMVLGL KEIQIRGEIR TNVDYTIDLL HASDYRENKI HTGWLDSRIA
MRVRAERPPW YLSVVGGALY KASATSAAVV SDYVGYLEKG QIPPKHISLV HSQVSLNIEG
SKYTIDVVRG GSGSYRLRMN NSEVVAEIHT LRDGGLLMQA
//
