ID MOEA1_MYCTU Reviewed; 426 AA.
AC O05577; L0T705;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 01-MAY-2013, entry version 92.
DE RecName: Full=Molybdopterin molybdenumtransferase 1;
DE Short=MPT Mo-transferase 1;
DE EC=2.10.1.1;
GN Name=moeA1; Synonyms=moeA; OrderedLocusNames=Rv0994, MT1023;
GN ORFNames=MTCI237.08;
OS Mycobacterium tuberculosis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Catalyzes the insertion of molybdate into adenylated
CC molybdopterin with the concomitant release of AMP (By similarity).
CC -!- CATALYTIC ACTIVITY: Adenylyl-molybdopterin + molybdate =
CC molybdenum cofactor + AMP.
CC -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC -!- SIMILARITY: Belongs to the MoeA family.
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DR EMBL; BX842575; CAE55346.1; -; Genomic_DNA.
DR EMBL; AE000516; AAK45270.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP43744.1; -; Genomic_DNA.
DR PIR; E70601; E70601.
DR RefSeq; NP_335456.1; NC_002755.2.
DR RefSeq; YP_006514354.1; NC_018143.1.
DR RefSeq; YP_177776.1; NC_000962.3.
DR ProteinModelPortal; O05577; -.
DR SMR; O05577; 30-404.
DR STRING; 83332.Rv0994; -.
DR PRIDE; O05577; -.
DR EnsemblBacteria; AAK45270; AAK45270; MT1023.
DR GeneID; 13319554; -.
DR GeneID; 885404; -.
DR GeneID; 925593; -.
DR KEGG; mtc:MT1023; -.
DR KEGG; mtu:Rv0994; -.
DR KEGG; mtv:RVBD_0994; -.
DR PATRIC; 18123990; VBIMycTub22151_1118.
DR TubercuList; Rv0994; -.
DR eggNOG; COG0303; -.
DR HOGENOM; HOG000280651; -.
DR KO; K03750; -.
DR OMA; AVIQFED; -.
DR ProtClustDB; CLSK799347; -.
DR UniPathway; UPA00344; -.
DR GO; GO:0005829; C:cytosol; IDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 2.40.340.10; -; 1.
DR Gene3D; 3.40.980.10; -; 1.
DR InterPro; IPR020817; Mo_cofactor_synthesis.
DR InterPro; IPR005111; MoeA_C_domain_IV.
DR InterPro; IPR005110; MoeA_linker/N.
DR InterPro; IPR001453; Mopterin-bd_dom.
DR Pfam; PF00994; MoCF_biosynth; 1.
DR Pfam; PF03454; MoeA_C; 1.
DR Pfam; PF03453; MoeA_N; 1.
DR SMART; SM00852; MoCF_biosynth; 1.
DR SUPFAM; SSF53218; MoCF_biosynth; 1.
DR SUPFAM; SSF63867; MoeA_C; 1.
DR SUPFAM; SSF63882; MoeA_N; 1.
DR TIGRFAMs; TIGR00177; molyb_syn; 1.
DR PROSITE; PS01079; MOCF_BIOSYNTHESIS_2; FALSE_NEG.
PE 3: Inferred from homology;
KW Complete proteome; Magnesium; Metal-binding; Molybdenum;
KW Molybdenum cofactor biosynthesis; Reference proteome; Transferase.
FT CHAIN 1 426 Molybdopterin molybdenumtransferase 1.
FT /FTId=PRO_0000170991.
SQ SEQUENCE 426 AA; 44337 MW; F6A96255C92B77DB CRC64;
MRSVEEQQAR ISAAAVAPRP IRVAIAEAQG LMCAEEVVTE RPMPGFDQAA IDGYAVRSVD
VAGVGDTGGV QVFADHGDLD GRDVLTLPVM GTIEAGARTL SRLQPRQAVR VQTGAPLPTL
ADAVLPLRWT DGGMSRVRVL RGAPSGAYVR RAGDDVQPGD VAVRAGTIIG AAQVGLLAAV
GRERVLVHPR PRLSVMAVGG ELVDISRTPG NGQVYDVNSY ALAAAGRDAC AEVNRVGIVS
NDPTELGEIV EGQLNRAEVV VIAGGVGGAA AEAVRSVLSE LGEMEVVRVA MHPGSVQGFG
QLGRDGVPTF LLPANPVSAL VVFEVMVRPL IRLSLGKRHP MRRIVSARTL SPITSVAGRK
GYLRGQLMRD QDSGEYLVQA LGGAPGASSH LLATLAEANC LVVVPTGAEQ IRTGEIVDVA
FLAQHG
//
