ID O06441_RHOSO Unreviewed; 322 AA.
AC O06441;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Heroin esterase {ECO:0000313|EMBL:AAC45283.1};
GN Name=her {ECO:0000313|EMBL:AAC45283.1};
OS Rhodococcus sp.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1831 {ECO:0000313|EMBL:AAC45283.1};
RN [1] {ECO:0000313|EMBL:AAC45283.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H1 {ECO:0000313|EMBL:AAC45283.1};
RX PubMed=9143135;
RA Rathbone D.A., Holt P.J., Lowe C.R., Bruce N.C.;
RT "Molecular analysis of the Rhodococcus sp. strain H1 her gene and
RT characterization of its product, a heroin esterase, expressed in
RT Escherichia coli.";
RL Appl. Environ. Microbiol. 63:2062-2066(1997).
RN [2] {ECO:0007829|PDB:1LZK, ECO:0007829|PDB:1LZL}
RP X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 1-307.
RX PubMed=12421810; DOI=10.1074/jbc.M210103200;
RA Zhu X., Larsen N.A., Basran A., Bruce N.C., Wilson I.A.;
RT "Observation of an arsenic adduct in an acetyl esterase crystal
RT structure.";
RL J. Biol. Chem. 278:2008-2014(2003).
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DR EMBL; U70619; AAC45283.1; -; Genomic_DNA.
DR PDB; 1LZK; X-ray; 1.45 A; A=1-307.
DR PDB; 1LZL; X-ray; 1.30 A; A=1-307.
DR PDBsum; 1LZK; -.
DR PDBsum; 1LZL; -.
DR AlphaFoldDB; O06441; -.
DR SMR; O06441; -.
DR ESTHER; rhosp-hercx; Hormone-sensitive_lipase_like.
DR EvolutionaryTrace; O06441; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR PANTHER; PTHR48081; AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C; 1.
DR PANTHER; PTHR48081:SF31; ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07859; Abhydrolase_3; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:1LZK, ECO:0007829|PDB:1LZL}.
FT DOMAIN 82..292
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
SQ SEQUENCE 322 AA; 34240 MW; 93B01D5C760B4A1E CRC64;
MTTFPTLDPE LAAALTMLPK VDFADLPNAR ATYDALIGAM LADLSFDGVS LRELSAPGLD
GDPEVKIRFV TPDNTAGPVP VLLWIHGGGF AIGTAESSDP FCVEVARELG FAVANVEYRL
APETTFPGPV NDCYAALLYI HAHAEELGID PSRIAVGGES AGGGLAAGTV LKARDEGVVP
VAFQFLEIPE LDDRLETVSM TNFVDTPLWH RPNAILSWKY YLGESYSGPE DPDVSIYAAP
SRATDLTGLP PTYLSTMELD PLRDEGIEYA LRLLQAGVSV ELHSFPGTFH GSALVATAGV
RERGAAKPHC DPERVAFAVA VS
//
