ID O06546_MYCTU Unreviewed; 470 AA.
AC O06546; I6XX75; L0T615;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Probable conserved transmembrane transport protein MmpL13b {ECO:0000313|EMBL:CCP43901.1};
GN Name=mmpL13b {ECO:0000313|EMBL:CCP43901.1};
GN OrderedLocusNames=Rv1146 {ECO:0000313|EMBL:CCP43901.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP43901.1, ECO:0000313|Proteomes:UP000001584};
RN [1] {ECO:0000313|EMBL:CCP43901.1, ECO:0000313|Proteomes:UP000001584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; AL123456; CCP43901.1; -; Genomic_DNA.
DR RefSeq; NP_215662.1; NC_000962.3.
DR RefSeq; WP_003904560.1; NC_000962.3.
DR AlphaFoldDB; O06546; -.
DR SMR; O06546; -.
DR STRING; 83332.Rv1146; -.
DR PaxDb; 83332-Rv1146; -.
DR DNASU; 885575; -.
DR GeneID; 885575; -.
DR KEGG; mtu:Rv1146; -.
DR PATRIC; fig|83332.111.peg.1281; -.
DR eggNOG; COG2409; Bacteria.
DR InParanoid; O06546; -.
DR OrthoDB; 7051771at2; -.
DR PhylomeDB; O06546; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0052559; P:induction by symbiont of host immune response; IDA:MTBBASE.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001584};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..422
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 443..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 50059 MW; 3401B2DB9D16FFF7 CRC64;
MATVAFVATA SIVITPAAIV LLGPRLDALD VRRLVRRLLG RPDPVHKPVK QLFWYRSSKF
VMRRWLPVGT AVVALLVLLG LPFLSVKWGF PDDRVLPRSA SARQVGDILR DDFGHDPATQ
IPIVVPDARG LGPVELDSYA AELSRVPDVS AVAAPTGTFV DGSWVGTPRG ATGLAEGSAF
LTVSSTAPLF SRASDIQLKR LHQVAGPAGR SVVMAGVAQV NRDSVDAVTD RLPMVLGLIA
AITYVLLFLL TGSVVLPAKA LVCNVLSLTA AFGALVWIFQ EGHFGALGTT PSGTLVANMP
VLLFCIAFGL SMDYEVFLVS RIREYWLESG AARPARRSVA EVHAANDESV ALGVARTGRV
ITAAALVMSM SFAALIAAHV SFMRMFGLGL TLAVAADATL VRMVVVPAFM HVTGRWNWWA
PRPLAWLHER FGVSEAAEPV SRRRSHAGGL GKIAGRSDGQ TIPASLTRNG
//
