ID GANR_BACSU Reviewed; 330 AA.
AC O07008; Q795J6;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 29-MAY-2013, entry version 88.
DE RecName: Full=HTH-type transcriptional regulator GanR;
GN Name=ganR; Synonyms=lacR, yvfJ; OrderedLocusNames=BSU34170;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=9287030;
RA Daniel R.A., Haiech J., Denizot F., Errington J.;
RT "Isolation and characterization of the lacA gene encoding beta-
RT galactosidase in Bacillus subtilis and a regulator gene, lacR.";
RL J. Bacteriol. 179:5636-5638(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Denizot F.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP FUNCTION.
RC STRAIN=168;
RX PubMed=2104611;
RA Errington J., Vogt C.H.;
RT "Isolation and characterization of mutations in the gene encoding an
RT endogenous Bacillus subtilis beta-galactosidase and its regulator.";
RL J. Bacteriol. 172:488-490(1990).
CC -!- FUNCTION: Negatively regulates expression of ganA.
CC -!- SIMILARITY: Contains 1 HTH lacI-type DNA-binding domain.
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DR EMBL; Z94043; CAB08004.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15422.1; -; Genomic_DNA.
DR PIR; C69649; C69649.
DR RefSeq; NP_391297.1; NC_000964.3.
DR ProteinModelPortal; O07008; -.
DR SMR; O07008; 2-330.
DR STRING; 224308.BSU34170; -.
DR PaxDb; O07008; -.
DR EnsemblBacteria; CAB15422; CAB15422; BSU34170.
DR GeneID; 936331; -.
DR KEGG; bsu:BSU34170; -.
DR PATRIC; 18978836; VBIBacSub10457_3581.
DR GenoList; BSU34170; -.
DR eggNOG; COG1609; -.
DR HOGENOM; HOG000220180; -.
DR KO; K02529; -.
DR OMA; IAIPNRV; -.
DR ProtClustDB; CLSK873198; -.
DR BioCyc; BSUB:BSU34170-MONOMER; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR010982; Lambda_DNA-bd_dom.
DR InterPro; IPR000843; Tscrpt_reg_HTH_LacI.
DR Pfam; PF00356; LacI; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; Lambda_like_DNA; 1.
DR PROSITE; PS00356; HTH_LACI_1; FALSE_NEG.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW Complete proteome; DNA-binding; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1 330 HTH-type transcriptional regulator GanR.
FT /FTId=PRO_0000381931.
FT DOMAIN 2 57 HTH lacI-type.
FT DNA_BIND 4 23 H-T-H motif (By similarity).
SQ SEQUENCE 330 AA; 37462 MW; 12285A5EB181D4BF CRC64;
MATIKDIAQE AGFSISTVSR VLNNDESLSV PDETREKIYE AAEKLNYRKK TVRPLVKHIA
FLYWLTDKEE LEDVYFKTMR LEVEKLAKAF NVDMTTYKIA DGIESIPEHT EGFIAVGTFS
DEELAFLRNL TENGVFIDST PDPDHFDSVR PDLAQMTRKT VNILTEKGHK SIGFIGGTYK
NPNTNQDEMD IREQTFRSYM REKAMLDERY IFCHRGFSVE NGYRLMSAAI DTLGDQLPTA
FMIAADPIAV GCLQALNEKG IAIPNRVSIV SINNISFAKY VSPPLTTFHI DIHELCKNAV
QLLLEQVQDK RRTVKTLYVG AELIVRKSMN
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