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Database: UniProt
Entry: O07008
LinkDB: O07008
Original site: O07008 
ID   GANR_BACSU              Reviewed;         330 AA.
AC   O07008; Q795J6;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   29-OCT-2014, entry version 96.
DE   RecName: Full=HTH-type transcriptional regulator GanR;
GN   Name=ganR; Synonyms=lacR, yvfJ; OrderedLocusNames=BSU34170;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=9287030;
RA   Daniel R.A., Haiech J., Denizot F., Errington J.;
RT   "Isolation and characterization of the lacA gene encoding beta-
RT   galactosidase in Bacillus subtilis and a regulator gene, lacR.";
RL   J. Bacteriol. 179:5636-5638(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Denizot F.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=2104611;
RA   Errington J., Vogt C.H.;
RT   "Isolation and characterization of mutations in the gene encoding an
RT   endogenous Bacillus subtilis beta-galactosidase and its regulator.";
RL   J. Bacteriol. 172:488-490(1990).
CC   -!- FUNCTION: Negatively regulates expression of ganA.
CC       {ECO:0000269|PubMed:2104611, ECO:0000269|PubMed:9287030}.
CC   -!- SIMILARITY: Contains 1 HTH lacI-type DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00111}.
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DR   EMBL; Z94043; CAB08004.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15422.1; -; Genomic_DNA.
DR   PIR; C69649; C69649.
DR   RefSeq; NP_391297.1; NC_000964.3.
DR   ProteinModelPortal; O07008; -.
DR   SMR; O07008; 2-330.
DR   STRING; 224308.BSU34170; -.
DR   PaxDb; O07008; -.
DR   EnsemblBacteria; CAB15422; CAB15422; BSU34170.
DR   GeneID; 936331; -.
DR   KEGG; bsu:BSU34170; -.
DR   PATRIC; 18978836; VBIBacSub10457_3581.
DR   GenoList; BSU34170; -.
DR   eggNOG; COG1609; -.
DR   HOGENOM; HOG000220180; -.
DR   KO; K02529; -.
DR   OMA; WLTDKEE; -.
DR   OrthoDB; EOG6SJJMM; -.
DR   PhylomeDB; O07008; -.
DR   BioCyc; BSUB:BSU34170-MONOMER; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000843; Tscrpt_reg_HTH_LacI.
DR   Pfam; PF00356; LacI; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    330       HTH-type transcriptional regulator GanR.
FT                                /FTId=PRO_0000381931.
FT   DOMAIN        2     57       HTH lacI-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00111}.
FT   DNA_BIND      4     23       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00111}.
SQ   SEQUENCE   330 AA;  37462 MW;  12285A5EB181D4BF CRC64;
     MATIKDIAQE AGFSISTVSR VLNNDESLSV PDETREKIYE AAEKLNYRKK TVRPLVKHIA
     FLYWLTDKEE LEDVYFKTMR LEVEKLAKAF NVDMTTYKIA DGIESIPEHT EGFIAVGTFS
     DEELAFLRNL TENGVFIDST PDPDHFDSVR PDLAQMTRKT VNILTEKGHK SIGFIGGTYK
     NPNTNQDEMD IREQTFRSYM REKAMLDERY IFCHRGFSVE NGYRLMSAAI DTLGDQLPTA
     FMIAADPIAV GCLQALNEKG IAIPNRVSIV SINNISFAKY VSPPLTTFHI DIHELCKNAV
     QLLLEQVQDK RRTVKTLYVG AELIVRKSMN
//
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