ID   O07365_CHLTH            Unreviewed;       676 AA.
AC   O07365;
DT   01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT   01-JUL-1997, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
DE   Flags: Fragment;
OS   Chlamydia trachomatis.
OC   Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=813 {ECO:0000313|EMBL:AAB58905.1};
RN   [1] {ECO:0000313|EMBL:AAB58905.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L2/434/Bu {ECO:0000313|EMBL:AAB58905.1};
RA   Raggiaschi R., Ratti G.;
RT   "The nusA gene of Chlamydia trachomatis.";
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000256|RuleBase:RU000644}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
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DR   EMBL; U74759; AAB58905.1; -; Genomic_DNA.
DR   AlphaFoldDB; O07365; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01887; IF2_eIF5B; 1.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR006847; IF2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00487; IF-2; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF04760; IF2_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000256|RuleBase:RU000644};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU000644}.
FT   DOMAIN          401..570
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
FT   REGION          32..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         676
FT                   /evidence="ECO:0000313|EMBL:AAB58905.1"
SQ   SEQUENCE   676 AA;  73125 MW;  F3D8E2637A68865B CRC64;
     MEKAKLTKNL KLKIKNAQLT KAAGLDKLKQ KLAQAGSSDT KNSPASKAQT KEKSSKKTAG
     TPAPAPEVDL GATESTARRI RAKDRSSFAA EPTVTTALPG DASHLTLDAI PAIKAPEITS
     VTQKEQTLRE CTDTSSVQQE EKKESSEETS PETPERIEET PIIRTRTEPK SVVSIKPKFG
     PTGKHINHLL AKTFKAPAKE TKAASTEETT QQQPRQNDAA SHNNKQQPSG TSSRPASSAP
     SYRRESTSNN NNNAKRGSER DRSKRSDESV KAFTGRDRYG LNEGSSEEDK WRKKRVHKTK
     KQAEEHVVQC PAHIKIALPI TVKDLAAEMK LKASELIQKL FIHGMTYVVN DVLDSQTVVE
     YIGLEFGCTI EIDSSAKEKL CLVENTVRDE VNATDPEKLI IRSPIVAFMG HVDHGKTTII
     DALRQSNMAA SEAGAITQHT GAFKCTTPVG EITVLDTPGH EAFSAMRARG AEVCDIVVLV
     VAGDEGIKKQ TIEAIEHAKG ANITIVVAIN KCDKPNFNVK TVYRQLAKLD LLPEAWGGSI
     ATINTSAKTG EGLQDLLEML ALQAEVLELK ADPSARARGL VIESELHKGL GAVATVLVQN
     GTLHLGEALV FNDCYGKVKT MHDEHNQLLQ SATPSTPVLI TGLSAIPKAG DPFIVVKNEK
     VAKEIISARL AGQQRS
//