ID SECY_STAA8 Reviewed; 430 AA.
AC O08387; Q2FW26;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 01-MAY-2013, entry version 81.
DE RecName: Full=Protein translocase subunit SecY;
GN Name=secY; OrderedLocusNames=SAOUHSC_02491;
OS Staphylococcus aureus (strain NCTC 8325).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCTC 8325;
RA Segarra R.A., Iandolo J.J.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W.,
RA Iandolo J.J.;
RT "The Staphylococcus aureus NCTC8325 genome.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The central subunit of the protein translocation channel
CC SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These
CC two domains form a lateral gate at the front which open onto the
CC bilayer between TMs 2 and 7, and are clamped together by SecE at
CC the back. The channel is closed by both a pore ring composed of
CC hydrophobic SecY resides and a short helix (helix 2A) on the
CC extracellular side of the membrane which forms a plug. The plug
CC probably moves laterally to allow the channel to open. The ring
CC and the pore may move independently (By similarity).
CC -!- SUBUNIT: Component of the Sec protein translocase complex.
CC Heterotrimer consisting of SecY, SecE and SecG subunits. The
CC heterotrimers can form oligomers, although 1 heterotrimer is
CC thought to be able to translocate proteins. Interacts with the
CC ribosome. Interacts with SecDF, and other proteins may be
CC involved. Interacts with SecA (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (By similarity).
CC -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB54022.1; Type=Frameshift; Positions=Several;
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DR EMBL; U96620; AAB54022.1; ALT_FRAME; Genomic_DNA.
DR EMBL; CP000253; ABD31510.1; -; Genomic_DNA.
DR RefSeq; YP_500959.1; NC_007795.1.
DR ProteinModelPortal; O08387; -.
DR SMR; O08387; 13-425.
DR STRING; 93061.SAOUHSC_02491; -.
DR EnsemblBacteria; ABD31510; ABD31510; SAOUHSC_02491.
DR GeneID; 3920868; -.
DR KEGG; sao:SAOUHSC_02491; -.
DR PATRIC; 19582282; VBIStaAur99865_2247.
DR eggNOG; COG0201; -.
DR HOGENOM; HOG000080586; -.
DR KO; K03076; -.
DR OMA; FIMWLGE; -.
DR ProtClustDB; PRK09204; -.
DR BioCyc; SAUR93061:GIWJ-2427-MONOMER; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:HAMAP.
DR GO; GO:0006605; P:protein targeting; IEA:HAMAP.
DR GO; GO:0043952; P:protein transport by the Sec complex; IEA:HAMAP.
DR Gene3D; 1.10.3370.10; -; 1.
DR HAMAP; MF_01465; SecY; 1; -.
DR InterPro; IPR026593; SecY.
DR InterPro; IPR002208; SecY/SEC61-alpha.
DR InterPro; IPR023201; SecY_su_dom.
DR PANTHER; PTHR10906; PTHR10906; 1.
DR Pfam; PF00344; SecY; 1.
DR PIRSF; PIRSF004557; SecY; 1.
DR SUPFAM; SSF103491; SecY; 1.
DR TIGRFAMs; TIGR00967; 3a0501s007; 1.
DR PROSITE; PS00755; SECY_1; 1.
DR PROSITE; PS00756; SECY_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 430 Protein translocase subunit SecY.
FT /FTId=PRO_0000131745.
FT TRANSMEM 18 38 Helical; (Potential).
FT TRANSMEM 68 88 Helical; (Potential).
FT TRANSMEM 117 137 Helical; (Potential).
FT TRANSMEM 147 167 Helical; (Potential).
FT TRANSMEM 179 199 Helical; (Potential).
FT TRANSMEM 217 237 Helical; (Potential).
FT TRANSMEM 269 289 Helical; (Potential).
FT TRANSMEM 308 328 Helical; (Potential).
FT TRANSMEM 368 388 Helical; (Potential).
FT TRANSMEM 389 409 Helical; (Potential).
FT CONFLICT 159 159 A -> T (in Ref. 1; AAB54022).
FT CONFLICT 200 202 GQT -> YQQ (in Ref. 1; AAB54022).
SQ SEQUENCE 430 AA; 47148 MW; 31B735FEC788F1E4 CRC64;
MIQTLVNFFR TKEVRNKIFF TLAMLVIFKI GTYIPAPGVN PAAFDNPQGS QGATELLNTF
GGGALKRFSI FAMGIVPYIT ASIVMQLLQM DIVPKFSEWA KQGEVGRRKL NNVTRYLAIS
LAFIQSIGMA FQFNNYLKGA LIINQSIMSY LLIALVLTAG TAFLIWLGDQ ITQFGVGNGI
SIIIFAGILS TLPASLIQFG QTAFVGQEDT SLAWLKVLGL LVSLILLTVG AIYVLEAVRK
IPIQYAKKQT AQRLGSQATY LPLKVNSAGV IPVIFAMAFF LLPRTLTLFY PDKEWAQNIA
NAANPSSNVG MVVYIVLIIL FTYFYAFVQV NPEKMADNLK KQGSYVPGIR PGEQTKKYIT
KVLYRLTFVG SIFLAVISIL PILATKFMGL PQSIQIGGTS LLIVIGVAIE TMKSLEAQVS
QKEYKGFGGR
//
