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Database: UniProt
Entry: O08467
LinkDB: O08467
Original site: O08467 
ID   GLNA_THEKO              Reviewed;         443 AA.
AC   O08467; Q5JJ67;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   13-NOV-2013, entry version 88.
DE   RecName: Full=Glutamine synthetase;
DE            Short=GS;
DE            EC=6.3.1.2;
DE   AltName: Full=Glutamate--ammonia ligase;
GN   Name=glnA; OrderedLocusNames=TK1796;
OS   Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=9172372;
RA   Adul Rahman R.N.Z., Jongsareejit B., Fujiwara S., Imanaka T.;
RT   "Characterization of recombinant glutamine synthetase from the
RT   hyperthermophilic archaeon Pyrococcus sp. strain KOD1.";
RL   Appl. Environ. Microbiol. 63:2472-2476(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon
RT   Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus
RT   genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + L-glutamate + NH(3) = ADP + phosphate +
CC       L-glutamine.
CC   -!- ENZYME REGULATION: The activity of this enzyme is controlled by
CC       adenylation under conditions of abundant glutamine. The fully
CC       adenylated enzyme complex is inactive (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the glutamine synthetase family.
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DR   EMBL; D86222; BAA20530.1; -; Genomic_DNA.
DR   EMBL; AP006878; BAD85985.1; -; Genomic_DNA.
DR   RefSeq; YP_184209.1; NC_006624.1.
DR   ProteinModelPortal; O08467; -.
DR   IntAct; O08467; 1.
DR   MINT; MINT-8377176; -.
DR   STRING; 69014.TK1796; -.
DR   EnsemblBacteria; BAD85985; BAD85985; TK1796.
DR   GeneID; 3233803; -.
DR   KEGG; tko:TK1796; -.
DR   eggNOG; COG0174; -.
DR   HOGENOM; HOG000005156; -.
DR   KO; K01915; -.
DR   OMA; AEDDVWS; -.
DR   ProtClustDB; CLSK491907; -.
DR   BioCyc; TKOD69014:GH72-1833-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004356; F:glutamate-ammonia ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:InterPro.
DR   Gene3D; 3.10.20.70; -; 1.
DR   Gene3D; 3.30.590.10; -; 1.
DR   InterPro; IPR008147; Gln_synt_beta.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   InterPro; IPR008146; Gln_synth_cat_dom.
DR   InterPro; IPR027303; Gln_synth_gly_rich_site.
DR   InterPro; IPR004809; Gln_synth_I.
DR   InterPro; IPR027302; Gln_synth_N_conserv_site.
DR   Pfam; PF00120; Gln-synt_C; 1.
DR   Pfam; PF03951; Gln-synt_N; 1.
DR   SUPFAM; SSF54368; SSF54368; 1.
DR   TIGRFAMs; TIGR00653; GlnA; 1.
DR   PROSITE; PS00180; GLNA_1; 1.
DR   PROSITE; PS00181; GLNA_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN         1    443       Glutamine synthetase.
FT                                /FTId=PRO_0000153211.
FT   MOD_RES     362    362       O-AMP-tyrosine (By similarity).
FT   CONFLICT    402    402       Y -> N (in Ref. 1; BAA20530).
SQ   SEQUENCE   443 AA;  50308 MW;  94357E45D5F18168 CRC64;
     MNEIKGIERA VQVEVPRPRF LLLAFTDING SLKGMEIPME RYEEAVEDGV SFDGSSIPGF
     EGIEDSDLIF KADPSTYAEI PWEGIGRVYG YIYKGDEPYQ ADPRGILKRV LERLEKEGLK
     AHIGPEPEFY IFKKNGTWEL HIPDSGGYFD LVGLDKAREI RREIALYMPY LGLKPEVLHH
     EVGKAQHEID FRYDEALRTA DNIVSFKHVV KAVAELHGYY ATFMPKPIYG FPGNGMHLHI
     SLWKDGENVF IGEDGLSDTA LHFIGGILKH AKALAALTNP TVNSYKRLVP GYEAPVYISW
     GYRNRSALIR VPAFKGSGAR IEYRCPDPSA NPYLALAGIL MVGLDGIKKK VEPDSYVETN
     VYEMDDAERE RLGIDTLPGS LGEALEELKK DKTVREALGG AYKNFIDYKE REWEEYIEYL
     SSRDIPIDTK KVTEWELERY FYV
//
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