ID O13256_CHICK Unreviewed; 476 AA.
AC O13256;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 24-JAN-2024, entry version 108.
DE RecName: Full=2'-5' oligoadenylate synthase {ECO:0000256|ARBA:ARBA00012577};
DE EC=2.7.7.84 {ECO:0000256|ARBA:ARBA00012577};
GN Name=OAS*B {ECO:0000313|EMBL:BAA19575.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:BAA19575.1};
RN [1] {ECO:0000313|EMBL:BAA19575.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=white leghorn {ECO:0000313|EMBL:BAA19575.1};
RX PubMed=9473666; DOI=10.1016/S0167-4781(97)00148-6;
RA Yamamoto A., Iwata A., Koh Y., Kawai S., Murayama S., Hamada K.,
RA Maekawa S., Ueda S., Sokawa Y.;
RT "Two types of chicken 2',5'-oligoadenylate synthetase mRNA derived from
RT alleles at a single locus.";
RL Biochim. Biophys. Acta 1395:181-191(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-
CC adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84;
CC Evidence={ECO:0000256|ARBA:ARBA00001112};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the 2-5A synthase family.
CC {ECO:0000256|ARBA:ARBA00009526}.
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DR EMBL; AB002586; BAA19575.1; -; mRNA.
DR RefSeq; NP_990372.1; NM_205041.1.
DR AlphaFoldDB; O13256; -.
DR SMR; O13256; -.
DR KEGG; gga:395908; -.
DR VEuPathDB; HostDB:geneid_395908; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001730; F:2'-5'-oligoadenylate synthetase activity; IEA:UniProtKB-EC.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd05400; NT_2-5OAS_ClassI-CCAase; 1.
DR CDD; cd01811; Ubl1_OASL; 1.
DR Gene3D; 1.10.1410.20; 2'-5'-oligoadenylate synthetase 1, domain 2; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR018952; 2-5-oligoAdlate_synth_1_dom2/C.
DR InterPro; IPR006117; 2-5OAS_C_CS.
DR InterPro; IPR006116; NT_2-5OAS_ClassI-CCAase.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019956; Ubiquitin_dom.
DR PANTHER; PTHR11258:SF7; 2'-5'-OLIGOADENYLATE SYNTHASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR11258; 2-5 OLIGOADENYLATE SYNTHETASE; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF10421; OAS1_C; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM00213; UBQ; 2.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS00833; 25A_SYNTH_2; 1.
DR PROSITE; PS50152; 25A_SYNTH_3; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 2.
PE 2: Evidence at transcript level;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588}.
FT DOMAIN 342..392
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT DOMAIN 391..465
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
SQ SEQUENCE 476 AA; 54309 MW; 0A13C7DDFE3BFEC6 CRC64;
MGLESVSSRQ LEGWVAAHLQ PSTEFSTAVK QTVKDICDFL KERCFEGISV LKTVKGGSAG
KGTALRNNSD ADVVLFINCF SSYQEQEARR GHILAIIERR LNECLPTLSF GVSITSPRYK
DSRDRPRSLS LTLSSSASSE SIDVDILPAY DALGQVIQDA RPDPAVYVKL LATRCGPGDF
SPSFTELQKN FVKWRPAKLK DLLRLVKHWY KEMLKPKYPN AKLPPKYALE LLTIYAWEEG
TGREDFSMAE GFCTVLELLG QYRDICIYWE KYYSLEDEWV GAYLKEQLRQ PRPVILDPAD
PTGILGQGKN WDLVAKEAAE SRVSLPCVSD VCSWDVQPTR PVKVQVKQLQ GMSLTRKVHP
STTVWELKGE IEKEWCIPRY QQRLYTEPQE MEVLVKDSNK TTVYTVRPTD TVKQLKQQIY
ARQHVPVEQQ RLTYETKELE NHHTLEHYHV QPRSTIYLLL RLRGGAGPLP RRCVPS
//
