ID O13J1_HUMAN Reviewed; 312 AA.
AC Q8NGT2; B2RN66; Q6IF20; Q96R40;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 155.
DE RecName: Full=Olfactory receptor 13J1;
DE AltName: Full=Olfactory receptor OR9-2;
GN Name=OR13J1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13J1";
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DR EMBL; AB065705; BAC05928.1; -; Genomic_DNA.
DR EMBL; AL133410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471071; EAW58323.1; -; Genomic_DNA.
DR EMBL; BC136715; AAI36716.1; -; mRNA.
DR EMBL; BC136716; AAI36717.1; -; mRNA.
DR EMBL; AF399603; AAK95088.1; -; Genomic_DNA.
DR EMBL; BK004442; DAA04840.1; -; Genomic_DNA.
DR CCDS; CCDS35011.1; -.
DR RefSeq; NP_001004487.1; NM_001004487.1.
DR AlphaFoldDB; Q8NGT2; -.
DR SMR; Q8NGT2; -.
DR BioGRID; 134172; 10.
DR STRING; 9606.ENSP00000367219; -.
DR GlyCosmos; Q8NGT2; 2 sites, No reported glycans.
DR GlyGen; Q8NGT2; 2 sites.
DR PhosphoSitePlus; Q8NGT2; -.
DR BioMuta; OR13J1; -.
DR DMDM; 38372769; -.
DR MassIVE; Q8NGT2; -.
DR PaxDb; 9606-ENSP00000367219; -.
DR PeptideAtlas; Q8NGT2; -.
DR Antibodypedia; 54541; 74 antibodies from 14 providers.
DR DNASU; 392309; -.
DR Ensembl; ENST00000377981.4; ENSP00000367219.2; ENSG00000168828.6.
DR GeneID; 392309; -.
DR KEGG; hsa:392309; -.
DR MANE-Select; ENST00000377981.4; ENSP00000367219.2; NM_001004487.1; NP_001004487.1.
DR UCSC; uc011lph.3; human.
DR AGR; HGNC:15108; -.
DR CTD; 392309; -.
DR DisGeNET; 392309; -.
DR GeneCards; OR13J1; -.
DR HGNC; HGNC:15108; OR13J1.
DR HPA; ENSG00000168828; Tissue enhanced (retina).
DR neXtProt; NX_Q8NGT2; -.
DR PharmGKB; PA32049; -.
DR VEuPathDB; HostDB:ENSG00000168828; -.
DR eggNOG; ENOG502RNT5; Eukaryota.
DR GeneTree; ENSGT01040000240406; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGT2; -.
DR OMA; FTVLYAM; -.
DR OrthoDB; 4634741at2759; -.
DR PhylomeDB; Q8NGT2; -.
DR TreeFam; TF352686; -.
DR PathwayCommons; Q8NGT2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 392309; 19 hits in 751 CRISPR screens.
DR GeneWiki; OR13J1; -.
DR GenomeRNAi; 392309; -.
DR Pharos; Q8NGT2; Tdark.
DR PRO; PR:Q8NGT2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGT2; Protein.
DR Bgee; ENSG00000168828; Expressed in prefrontal cortex and 41 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR CDD; cd15430; 7tmA_OR13-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF38; OLFACTORY RECEPTOR 13J1; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 13J1"
FT /id="PRO_0000150741"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 133
FT /note="H -> R (in dbSNP:rs7044405)"
FT /id="VAR_053304"
SQ SEQUENCE 312 AA; 34689 MW; 7AE2FAB223A9218B CRC64;
MEPLNRTEVS EFFLKGFSGY PALEHLLFPL CSAMYLVTLL GNTAIMAVSV LDIHLHTPVY
FFLGNLSTLD ICYTPTFVPL MLVHLLSSRK TISFAVCAIQ MCLSLSTGST ECLLLAITAY
DRYLAICQPL RYHVLMSHRL CVLLMGAAWV LCLLKSVTEM VISMRLPFCG HHVVSHFTCK
ILAVLKLACG NTSVSEDFLL AGSILLLPVP LAFICLSYLL ILATILRVPS AARCCKAFST
CLAHLAVVLL FYGTIIFMYL KPKSKEAHIS DEVFTVLYAM VTTMLNPTIY SLRNKEVKEA
ARKVWGRSRA SR
//
