ID TR10B_HUMAN Reviewed; 440 AA.
AC O14763; O14720; O15508; O15517; O15531; Q6UXM8; Q7Z360; Q9BVE0;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 01-MAY-2013, entry version 148.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 10B;
DE AltName: Full=Death receptor 5;
DE AltName: Full=TNF-related apoptosis-inducing ligand receptor 2;
DE Short=TRAIL receptor 2;
DE Short=TRAIL-R2;
DE AltName: CD_antigen=CD262;
DE Flags: Precursor;
GN Name=TNFRSF10B; Synonyms=DR5, KILLER, TRAILR2, TRICK2, ZTNFR9;
GN ORFNames=UNQ160/PRO186;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), ALTERNATIVE
RP SPLICING, AND VARIANTS LEU-32; VAL-67 AND ALA-191.
RX PubMed=9285725; DOI=10.1016/S0960-9822(06)00297-1;
RA Screaton G.R., Mongkolsapaya J., Xu X.-N., Cowper A.E.,
RA McMichael A.J., Bell J.I.;
RT "TRICK2, a new alternatively spliced receptor that transduces the
RT cytotoxic signal from TRAIL.";
RL Curr. Biol. 7:693-696(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), PROTEIN SEQUENCE OF
RP N-TERMINUS, AND VARIANT ALA-191.
RC TISSUE=Foreskin fibroblast;
RX PubMed=9311998; DOI=10.1093/emboj/16.17.5386;
RA Walczak H., Degli-Esposti M.A., Johnson R.S., Smolak P.J., Waugh J.Y.,
RA Boiani N., Timour M.S., Gerhart M.J., Schooley K.A., Smith C.A.,
RA Goodwin R.G., Rauch C.T.;
RT "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.";
RL EMBO J. 16:5386-5397(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), CHARACTERIZATION, AND
RP VARIANTS LEU-32; VAL-67 AND ALA-191.
RC TISSUE=Liver, and Spleen;
RX PubMed=9373179; DOI=10.1016/S0014-5793(97)01231-3;
RA Schneider P., Bodmer J.-L., Thome M., Hofmann K., Holler N.,
RA Tschopp J.;
RT "Characterization of two receptors for TRAIL.";
RL FEBS Lett. 416:329-334(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), AND VARIANTS LEU-32 AND
RP VAL-67.
RX PubMed=9430227; DOI=10.1016/S1074-7613(00)80400-8;
RA Chaudhary P.M., Eby M., Jasmin A., Bookwalter A., Murray J., Hood L.;
RT "Death receptor 5, a new member of the TNFR family, and DR4 induce
RT FADD-dependent apoptosis and activate the NF-kappaB pathway.";
RL Immunity 7:821-830(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), AND VARIANTS LEU-32 AND
RP VAL-67.
RX PubMed=9325248; DOI=10.1074/jbc.272.41.25417;
RA MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T.,
RA Cohen G.M., Alnemri E.S.;
RT "Identification and molecular cloning of two novel receptors for the
RT cytotoxic ligand TRAIL.";
RL J. Biol. Chem. 272:25417-25420(1997).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC TISSUE=Ovary;
RX PubMed=9326928; DOI=10.1038/ng1097-141;
RA Wu G.S., Burns T.F., McDonald E.R. III, Jiang W., Meng R.,
RA Krantz I.D., Kao G., Gan D.D., Zhou J.Y., Muschel R., Hamilton S.R.,
RA Spinner N.B., Markowitz S., Wu G., el-Deiry W.S.;
RT "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor
RT gene.";
RL Nat. Genet. 17:141-143(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RX PubMed=9242610; DOI=10.1126/science.277.5327.815;
RA Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M.;
RT "An antagonist decoy receptor and a death domain-containing receptor
RT for TRAIL.";
RL Science 277:815-818(1997).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), AND VARIANT LEU-32.
RX PubMed=9242611; DOI=10.1126/science.277.5327.818;
RA Sheridan J.P., Marsters S.A., Pitti R.M., Gurney A., Skubatch M.,
RA Baldwin D.T., Ramakrishnan L., Gray C.L., Baker K., Wood W.I.,
RA Goddard A.D., Godowski P.J., Ashkenazi A.;
RT "Control of TRAIL-induced apoptosis by a family of signaling and decoy
RT receptors.";
RL Science 277:818-821(1997).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND VARIANTS
RP LEU-32; VAL-67 AND ALA-191.
RX PubMed=10072170; DOI=10.1016/S0304-3835(98)00230-4;
RA Arai T., Akiyama Y., Okabe S., Saito K., Iwai T., Yuasa Y.;
RT "Genomic organization and mutation analyses of the DR5/TRAIL receptor
RT 2 gene in colorectal carcinomas.";
RL Cancer Lett. 133:197-204(1998).
RN [10]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RA Cao X., Zhang W., Wan T.;
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), AND VARIANTS LEU-32 AND
RP VAL-67.
RA Farrah T., Vu T., Gilbert T., Gross J., O'Hara P.;
RT "Homo sapiens homolog of tumor necrosis factor receptor.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT), AND VARIANT
RP LEU-32.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [13]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT
RP LEU-32.
RC TISSUE=Colon endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [14]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [15]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG), AND VARIANTS
RP LEU-32 AND ALA-191.
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [16]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
RN [17]
RP FUNCTION, AND INDUCTION.
RX PubMed=15322075; DOI=10.1074/jbc.M406933200;
RA Yamaguchi H., Wang H.G.;
RT "CHOP is involved in endoplasmic reticulum stress-induced apoptosis by
RT enhancing DR5 expression in human carcinoma cells.";
RL J. Biol. Chem. 279:45495-45502(2004).
RN [18]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 54-183.
RX PubMed=10549288; DOI=10.1016/S1097-2765(00)80207-5;
RA Hymowitz S.G., Christinger H.W., Fuh G., Ultsch M., O'Connell M.,
RA Kelley R.F., Ashkenazi A., de Vos A.M.;
RT "Triggering cell death: the crystal structure of Apo2L/TRAIL in a
RT complex with death receptor 5.";
RL Mol. Cell 4:563-571(1999).
RN [19]
RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 69-184.
RX PubMed=10542098; DOI=10.1038/14935;
RA Mongkolsapaya J., Grimes J.M., Chen N., Xu X.-N., Stuart D.I.,
RA Jones E.Y., Screaton G.R.;
RT "Structure of the TRAIL-DR5 complex reveals mechanisms conferring
RT specificity in apoptotic initiation.";
RL Nat. Struct. Biol. 6:1048-1053(1999).
CC -!- FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The
CC adapter molecule FADD recruits caspase-8 to the activated
CC receptor. The resulting death-inducing signaling complex (DISC)
CC performs caspase-8 proteolytic activation which initiates the
CC subsequent cascade of caspases (aspartate-specific cysteine
CC proteases) mediating apoptosis. Promotes the activation of NF-
CC kappa-B. Essential for ER stress-induced apoptosis.
CC -!- SUBUNIT: Homotrimer. Can interact with TRADD and RIPK1.
CC -!- INTERACTION:
CC P50591:TNFSF10; NbExp=23; IntAct=EBI-518882, EBI-495373;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=Long; Synonyms=TRICK2B;
CC IsoId=O14763-1; Sequence=Displayed;
CC Note=May be produced at very low levels due to a premature stop
CC codon in the mRNA, leading to nonsense-mediated mRNA decay;
CC Name=3;
CC IsoId=O14763-3; Sequence=VSP_039125;
CC Note=May be produced at very low levels due to a premature stop
CC codon in the mRNA, leading to nonsense-mediated mRNA decay;
CC Name=Short; Synonyms=TRICK2A;
CC IsoId=O14763-2; Sequence=VSP_006490;
CC Note=May be produced at very low levels due to a premature stop
CC codon in the mRNA, leading to nonsense-mediated mRNA decay;
CC -!- TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues;
CC very highly expressed in tumor cell lines such as HeLaS3, K-562,
CC HL-60, SW480, A-549 and G-361; highly expressed in heart,
CC peripheral blood lymphocytes, liver, pancreas, spleen, thymus,
CC prostate, ovary, uterus, placenta, testis, esophagus, stomach and
CC throughout the intestinal tract; not detectable in brain.
CC -!- INDUCTION: By ER stress. Regulated by p53/TP53.
CC -!- DISEASE: Squamous cell carcinoma of the head and neck (HNSCC)
CC [MIM:275355]: A non-melanoma skin cancer affecting the head and
CC neck. The hallmark of cutaneous SCC is malignant transformation of
CC normal epidermal keratinocytes. Note=The disease may be caused by
CC mutations affecting the gene represented in this entry.
CC -!- SIMILARITY: Contains 1 death domain.
CC -!- SIMILARITY: Contains 3 TNFR-Cys repeats.
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DR EMBL; AF018657; AAB70577.1; -; mRNA.
DR EMBL; AF018658; AAB70578.1; -; mRNA.
DR EMBL; AF016849; AAC51778.1; -; mRNA.
DR EMBL; AF016266; AAB81180.1; -; mRNA.
DR EMBL; AF016268; AAC01565.1; -; mRNA.
DR EMBL; AF020501; AAB71412.1; -; mRNA.
DR EMBL; AF022386; AAB71949.1; -; mRNA.
DR EMBL; AF012628; AAB67109.1; -; mRNA.
DR EMBL; AF012535; AAB67103.1; -; mRNA.
DR EMBL; AB014718; BAA33723.1; -; Genomic_DNA.
DR EMBL; AF153687; AAF75587.1; -; mRNA.
DR EMBL; AF192548; AAF07175.1; -; mRNA.
DR EMBL; AY358277; AAQ88644.1; -; mRNA.
DR EMBL; BX538104; CAD98017.1; -; mRNA.
DR EMBL; AC107959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001281; AAH01281.1; -; mRNA.
DR IPI; IPI00296379; -.
DR IPI; IPI00296380; -.
DR IPI; IPI00965817; -.
DR RefSeq; NP_003833.4; NM_003842.4.
DR RefSeq; NP_671716.2; NM_147187.2.
DR UniGene; Hs.521456; -.
DR PDB; 1D0G; X-ray; 2.40 A; R/S/T=54-183.
DR PDB; 1D4V; X-ray; 2.20 A; A=69-184.
DR PDB; 1DU3; X-ray; 2.20 A; A/B/C/G/H/I=54-183.
DR PDB; 1ZA3; X-ray; 3.35 A; R/S=54-183.
DR PDB; 2H9G; X-ray; 2.32 A; R/S=54-183.
DR PDBsum; 1D0G; -.
DR PDBsum; 1D4V; -.
DR PDBsum; 1DU3; -.
DR PDBsum; 1ZA3; -.
DR PDBsum; 2H9G; -.
DR ProteinModelPortal; O14763; -.
DR SMR; O14763; 69-184.
DR DIP; DIP-33566N; -.
DR IntAct; O14763; 4.
DR MINT; MINT-109111; -.
DR STRING; 9606.ENSP00000276431; -.
DR PhosphoSite; O14763; -.
DR PaxDb; O14763; -.
DR PRIDE; O14763; -.
DR DNASU; 8795; -.
DR Ensembl; ENST00000276431; ENSP00000276431; ENSG00000120889.
DR Ensembl; ENST00000347739; ENSP00000317859; ENSG00000120889.
DR GeneID; 8795; -.
DR KEGG; hsa:8795; -.
DR UCSC; uc003xct.2; human.
DR UCSC; uc003xcu.2; human.
DR CTD; 8795; -.
DR GeneCards; GC08M022877; -.
DR HGNC; HGNC:11905; TNFRSF10B.
DR HPA; HPA023625; -.
DR MIM; 275355; phenotype.
DR MIM; 603612; gene.
DR neXtProt; NX_O14763; -.
DR Orphanet; 67037; Squamous cell carcinoma of head and neck.
DR PharmGKB; PA36598; -.
DR eggNOG; NOG131298; -.
DR HOVERGEN; HBG061626; -.
DR InParanoid; O14763; -.
DR KO; K04722; -.
DR OMA; EMEVQEP; -.
DR OrthoDB; EOG476K1M; -.
DR PhylomeDB; O14763; -.
DR Pathway_Interaction_DB; trail_pathway; TRAIL signaling pathway.
DR Reactome; REACT_578; Apoptosis.
DR ChEMBL; CHEMBL1075153; -.
DR EvolutionaryTrace; O14763; -.
DR GenomeRNAi; 8795; -.
DR NextBio; 32984; -.
DR ArrayExpress; O14763; -.
DR Bgee; O14763; -.
DR CleanEx; HS_TNFRSF10B; -.
DR Genevestigator; O14763; -.
DR GermOnline; ENSG00000120889; Homo sapiens.
DR GO; GO:0016021; C:integral to membrane; IC:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004872; F:receptor activity; NAS:UniProtKB.
DR GO; GO:0045569; F:TRAIL binding; NAS:UniProtKB.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.
DR GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; NAS:UniProtKB.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; NAS:UniProtKB.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR011029; DEATH-like_dom.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020465; TNFR_10.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PIRSF; PIRSF037867; CD261_antigen; 1.
DR PRINTS; PR01956; TNFACTORR10.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF47986; DEATH_like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Apoptosis; Complete proteome;
KW Direct protein sequencing; Disulfide bond; Membrane; Polymorphism;
KW Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1 55
FT CHAIN 56 440 Tumor necrosis factor receptor
FT superfamily member 10B.
FT /FTId=PRO_0000034580.
FT TOPO_DOM 56 210 Extracellular (Potential).
FT TRANSMEM 211 231 Helical; (Potential).
FT TOPO_DOM 232 440 Cytoplasmic (Potential).
FT REPEAT 57 94 TNFR-Cys 1.
FT REPEAT 97 137 TNFR-Cys 2.
FT REPEAT 138 178 TNFR-Cys 3.
FT REPEAT 192 206 TAPE.
FT DOMAIN 339 422 Death.
FT COMPBIAS 250 253 Poly-Gly.
FT DISULFID 81 94
FT DISULFID 97 113
FT DISULFID 116 129
FT DISULFID 119 137
FT DISULFID 139 153
FT DISULFID 156 170
FT DISULFID 160 178
FT VAR_SEQ 119 440 Missing (in isoform 3).
FT /FTId=VSP_039125.
FT VAR_SEQ 185 213 Missing (in isoform Short).
FT /FTId=VSP_006490.
FT VARIANT 32 32 P -> L (in dbSNP:rs1129424).
FT /FTId=VAR_016153.
FT VARIANT 67 67 A -> V (in dbSNP:rs1047266).
FT /FTId=VAR_016154.
FT VARIANT 191 191 V -> A (in dbSNP:rs13265018).
FT /FTId=VAR_059831.
FT CONFLICT 439 439 M -> L (in Ref. 8; AAB67103 and 12;
FT AAQ88644).
FT STRAND 77 79
FT STRAND 85 87
FT STRAND 89 91
FT STRAND 94 96
FT TURN 99 101
FT STRAND 106 108
FT STRAND 110 112
FT STRAND 123 127
FT STRAND 131 133
FT STRAND 136 139
FT STRAND 144 146
FT STRAND 149 154
FT STRAND 165 168
FT STRAND 172 174
FT STRAND 177 179
SQ SEQUENCE 440 AA; 47878 MW; 60358EAF2A835870 CRC64;
MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD
LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD
SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH
KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV
LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV
NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK
LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED
HLLSSGKFMY LEGNADSAMS
//
