ID O15385_HUMAN Unreviewed; 210 AA.
AC O15385;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=NAD (H)-specific isocitrate dehydrogenase gamma subunit {ECO:0000313|EMBL:AAB70116.1};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAB70116.1};
RN [1] {ECO:0000313|EMBL:AAB70116.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Soares liver spleen 1NFLS {ECO:0000313|EMBL:AAB70116.1};
RX PubMed=9286695; DOI=10.1006/geno.1997.4822;
RA Brenner V., Nyakatura G., Rosenthal A., Platzer M.;
RT "Genomic organization of two novel genes on human Xq28: compact head to
RT head arrangement of IDH gamma and TRAP delta is conserved in rat and
RT mouse.";
RL Genomics 44:8-14(1997).
CC -!- SUBUNIT: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and
CC gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer
CC containing one IDH3A and one IDH3B subunit and the heterodimer
CC containing one IDH3A and one IDH3G subunit assemble into a
CC heterotetramer (which contains two subunits of IDH3A, one of IDH3B and
CC one of IDH3G) and further into the heterooctamer.
CC {ECO:0000256|ARBA:ARBA00011525}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; U69269; AAB70116.1; -; mRNA.
DR AlphaFoldDB; O15385; -.
DR SMR; O15385; -.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; NAS:UniProtKB.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF42; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT GAMMA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 2: Evidence at transcript level;
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 1..196
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAB70116.1"
SQ SEQUENCE 210 AA; 22706 MW; 2F83A837F5A59B1B CRC64;
KSLRIAEYAF KLAQESGRKK VTAVHKANIM KLGDGLFLQC CREVAARYPQ ITFENMIVDN
TTMQLVSRPQ QFDVMVMPNL YGNIVNNVCA GLVGGPGLVA GANYGHVYAV FETATRNTGK
SIANKNIANP TATLLASCMM LDHLKLHSYA TSIRKAVLAS MDNENGLVCA EPACVLQMHT
PDIGGQGTTS EAIQDVIRHI RVINGRAVEA
//
