ID O16915_CAEEL Unreviewed; 528 AA.
AC O16915;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 2.
DT 27-MAR-2024, entry version 153.
DE SubName: Full=Glucuronosyltransferase {ECO:0000313|EMBL:CCD69120.1};
GN Name=ugt-37 {ECO:0000313|EMBL:CCD69120.1,
GN ECO:0000313|WormBase:F10D2.6};
GN ORFNames=CELE_F10D2.6 {ECO:0000313|EMBL:CCD69120.1}, F10D2.6
GN {ECO:0000313|WormBase:F10D2.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD69120.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD69120.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69120.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; BX284605; CCD69120.1; -; Genomic_DNA.
DR PIR; T28720; T28720.
DR RefSeq; NP_504811.2; NM_072410.5.
DR AlphaFoldDB; O16915; -.
DR SMR; O16915; -.
DR STRING; 6239.F10D2.6.1; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR PaxDb; 6239-F10D2-6; -.
DR EnsemblMetazoa; F10D2.6.1; F10D2.6.1; WBGene00017332.
DR GeneID; 184293; -.
DR KEGG; cel:CELE_F10D2.6; -.
DR UCSC; F10D2.6; c. elegans.
DR AGR; WB:WBGene00017332; -.
DR WormBase; F10D2.6; CE30747; WBGene00017332; ugt-37.
DR eggNOG; KOG1192; Eukaryota.
DR GeneTree; ENSGT00970000196024; -.
DR HOGENOM; CLU_012949_1_4_1; -.
DR InParanoid; O16915; -.
DR OMA; ATDCMAG; -.
DR OrthoDB; 2880499at2759; -.
DR PhylomeDB; O16915; -.
DR Reactome; R-CEL-9753281; Paracetamol ADME.
DR Reactome; R-CEL-9757110; Prednisone ADME.
DR Reactome; R-CEL-9840309; Glycosphingolipid biosynthesis.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00017332; Expressed in larva and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF3; GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 485..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 528 AA; 60869 MW; D2CA3C478E478C27 CRC64;
MKILILLFAC FNVNFSYNFL IFSPLFGHSH TTFFAKIADT LSEAGHNVTF FTPTIIRKFS
KINYVKHTKH VIHLEPSEKL ERYGNQMEDV DISRFWTDDS SMAEMFPMIK LFNEMFAEQA
FVLGQNLDVL DELKEMKFDV MIFERFAECA YPLLEYLEIE TFIPSSSLLF DPNLLISIGE
PRIPSTVPLP MSKFTDKMTM TERLLNAIAV PIFHSLLPTH EFKSFRPPYQ AIDIQKMEHL
SSFILSNSNP YIDYPRPTLE KNVQIGGISV DVENLKIHKV NEEWDRILDM RQKTILVSFG
SVMLSKDMPV ENKKILAKTM KQFPEVTFIW KYEFNDTDLF ASETENIHFS SWVPQTALLA
DRRLTAFFTH AGLGSVNEVS YLGKPSIMCP IFADQMRNAK MLARHNGSIE ISKYDLGNGE
KIEKTLRTIL FDDSYRLSAE KLAHQLANQP VKPKELLLRH AEFAAQFGRL PSLDPYSRQL
SFVEYFLIDV AAILIFSSLL IVVVLFQIIK RLINFLPVTV DSRKVKTN
//
