ID   O17480_HYACE            Unreviewed;       752 AA.
AC   O17480;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=Moderately methionine rich hexamerin {ECO:0000313|EMBL:AAB86646.1};
OS   Hyalophora cecropia (Cecropia moth) (Samia cecropia).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Saturniinae; Attacini; Hyalophora.
OX   NCBI_TaxID=7123 {ECO:0000313|EMBL:AAB86646.1};
RN   [1] {ECO:0000313|EMBL:AAB86646.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Fat body {ECO:0000313|EMBL:AAB86646.1};
RA   Massey H.C. Jr.;
RT   "The Evolution of Insect Storage Proteins: Driven by Composition and
RT   Constrained by Sequence.";
RL   Thesis (1995), University of Pennsylvania.
RN   [2] {ECO:0000313|EMBL:AAB86646.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Fat body {ECO:0000313|EMBL:AAB86646.1};
RX   PubMed=9664700; DOI=10.1007/PL00006366;
RA   Burmester T., Massey H.C. Jr, Zakharkin S.O., Benes H.;
RT   "The evolution of hexamerins and the phylogeny of insects.";
RL   J. Mol. Evol. 47:93-108(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the hemocyanin family.
CC       {ECO:0000256|ARBA:ARBA00038082}.
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DR   EMBL; AF032398; AAB86646.1; -; mRNA.
DR   AlphaFoldDB; O17480; -.
DR   SMR; O17480; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   Gene3D; 2.60.40.1520; Hemocyanin, C-terminal domain; 1.
DR   Gene3D; 1.20.1370.10; Hemocyanin, N-terminal domain; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR013788; Hemocyanin/hexamerin.
DR   InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR   InterPro; IPR005203; Hemocyanin_C.
DR   InterPro; IPR037020; Hemocyanin_C_sf.
DR   InterPro; IPR005204; Hemocyanin_N.
DR   InterPro; IPR036697; Hemocyanin_N_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11511:SF5; FAT-BODY PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR11511; LARVAL STORAGE PROTEIN/PHENOLOXIDASE; 1.
DR   Pfam; PF03723; Hemocyanin_C; 1.
DR   Pfam; PF00372; Hemocyanin_M; 1.
DR   Pfam; PF03722; Hemocyanin_N; 1.
DR   PRINTS; PR00187; HAEMOCYANIN.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48050; Hemocyanin, N-terminal domain; 1.
DR   PROSITE; PS00209; HEMOCYANIN_1; 1.
DR   PROSITE; PS00210; HEMOCYANIN_2; 1.
PE   2: Evidence at transcript level;
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Storage protein {ECO:0000256|ARBA:ARBA00022761}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..752
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004157385"
FT   DOMAIN          33..153
FT                   /note="Hemocyanin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03722"
FT   DOMAIN          158..437
FT                   /note="Hemocyanin/hexamerin middle"
FT                   /evidence="ECO:0000259|Pfam:PF00372"
FT   DOMAIN          448..699
FT                   /note="Hemocyanin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03723"
SQ   SEQUENCE   752 AA;  88162 MW;  2C3C20AD068AB008 CRC64;
     MRAAVLLVLG LAAIASARPD NDDVNFVSMD IKQKQLFILK LLNHVTEPVM YKDVSEIGMN
     FKIEDNMELY TKTEVVKSFV NMLKVGVLPR GEVFTLNVDR QMKEVVNMFH ILYYAKDFST
     FIKTACWMRL YLNEGMFVYS LSVAVRYRED CKGVVLPPPY EIYPYYFVRA DVIQKAYLIK
     MRKGLLDLKL SEFYGIKKTE KDVYIIDENV YDRRVALNED DKIKYFTEDI DLNTYYYYFH
     VDYPFWMKDQ IFDKLKTRRF ELTLYIYQQI LARYYLERLS NGLGEIPEFS FYKPIQQGYW
     PWLKLHNGIE LPARFNNYVS YKYDNTELIS LVEEYETLIK EAIMKGYIDM NGIRLELTKP
     EDIETLGKMI YGKVAAKEQD SKCVEAYRYL LIVMKSAIGL NTLESDKYFV APTVLDSYQT
     ALRDPVFYQL QKRLVNIVQL FKKRLPCYTK EELYFPGVKI ENVVVDKLLT YFDDYFMDMT
     NAVTLSEEEI KKASASMGFL VRKRRLNHEP FKVSLEILSD KAVDCVVRIF MGPKEDQLGR
     LIDINKNRLN FVEMDSFVYK LTTGKNTIVR KSSDMHNLVP DRMMTSDLWK KVESITDMRD
     LFVKDLKNYF TGFPTRLLLP KGSVSGLPMV MYVMVSPLKL VDNVDMSAML DPTSKALSFD
     FRSTVLMDKM PLGFPLDRYI DVTNFYTSNM KFVDVTIFHK NQSCDMKMRW DKWVLKSYNL
     ASKTPIESNT YFVDTDLNSS SKVESSANVY DM
//