ID O17863_CAEEL Unreviewed; 328 AA.
AC O17863;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 3.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=Sidoreflexin {ECO:0000256|RuleBase:RU362000};
GN Name=sfxn-1.2 {ECO:0000313|EMBL:CAB04347.3,
GN ECO:0000313|WormBase:F37H8.4};
GN ORFNames=CELE_F37H8.4 {ECO:0000313|EMBL:CAB04347.3}, F37H8.4
GN {ECO:0000313|WormBase:F37H8.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB04347.3, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB04347.3, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB04347.3,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031,
CC ChEBI:CHEBI:33384; Evidence={ECO:0000256|ARBA:ARBA00036416};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC membrane {ECO:0000256|RuleBase:RU362000}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362000}.
CC -!- SIMILARITY: Belongs to the sideroflexin family.
CC {ECO:0000256|ARBA:ARBA00005974, ECO:0000256|RuleBase:RU362000}.
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DR EMBL; BX284602; CAB04347.3; -; Genomic_DNA.
DR PIR; T21924; T21924.
DR RefSeq; NP_496396.2; NM_063995.7.
DR AlphaFoldDB; O17863; -.
DR STRING; 6239.F37H8.4.1; -.
DR PaxDb; 6239-F37H8-4; -.
DR EnsemblMetazoa; F37H8.4.1; F37H8.4.1; WBGene00009513.
DR GeneID; 174708; -.
DR KEGG; cel:CELE_F37H8.4; -.
DR UCSC; F37H8.4; c. elegans.
DR AGR; WB:WBGene00009513; -.
DR WormBase; F37H8.4; CE35871; WBGene00009513; sfxn-1.2.
DR eggNOG; KOG3767; Eukaryota.
DR GeneTree; ENSGT01030000234641; -.
DR HOGENOM; CLU_039425_1_0_1; -.
DR InParanoid; O17863; -.
DR OMA; YSEYPIQ; -.
DR OrthoDB; 48449at2759; -.
DR PhylomeDB; O17863; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00009513; Expressed in adult organism and 2 other cell types or tissues.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015075; F:monoatomic ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0140300; P:serine import into mitochondrion; IBA:GO_Central.
DR InterPro; IPR004686; Mtc.
DR NCBIfam; TIGR00798; mtc; 1.
DR PANTHER; PTHR11153; SIDEROFLEXIN; 1.
DR PANTHER; PTHR11153:SF20; SIDEROFLEXIN-3; 1.
DR Pfam; PF03820; SFXNs; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362000};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU362000};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362000};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362000}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362000"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362000"
FT TRANSMEM 225..251
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362000"
FT TRANSMEM 271..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362000"
SQ SEQUENCE 328 AA; 36961 MW; 6625423156506D7B CRC64;
MSELVSNLKT RPDISKPQWS QRTYYGRVRH FFTLTNPLTL TSSVARQEQC RQIVLDYKNG
KVSPTLTVSE LWKAKTLYDS TYHPDTGEKM FFLGRMSAQM PANMLINGML LSLYRTFPGV
VFSHWINQSF NAVVNYTNRS GNSKTSNERL ILSYSCATGG AMAAALSLNA MVKNKNSIAA
RLVPFAAVAL ANTINIPMIR SNEVTEGLEL RDENGELLAR SRQMAILSIA QVTLSRIAMA
MPDMVMTPII MNRITRTMYY RTRPWMKYSE YPIQTMLAGM ALFFTTPMCC ALFPQKTAVE
VTKLEASVQK EIFSRADAPE VVFYNKGL
//
