ID O18936_AMBHO Unreviewed; 416 AA.
AC O18936;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=vWF {ECO:0000313|EMBL:AEP18850.1};
OS Amblysomus hottentotus (Hottentot golden mole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Chrysochloridae; Amblysominae; Amblysomus.
OX NCBI_TaxID=9391 {ECO:0000313|EMBL:AAB65641.1};
RN [1] {ECO:0000313|EMBL:AAB65641.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9214502; DOI=10.1038/40386;
RA Springer M.S., Cleven G.C., Madsen O.J., de Jong W.W., Waddell V.G.,
RA Amrine H.M., Stanhope M.J.;
RT "Endemic African mammals shake the phylogenetic tree.";
RL Nature 388:61-64(1997).
RN [2] {ECO:0000313|EMBL:AEP18850.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21940861; DOI=10.1126/science.1211028;
RA Meredith R.W., Janecka J.E., Gatesy J., Ryder O.A., Fisher C.A.,
RA Teeling E.C., Goodbla A., Eizirik E., Simao T.L., Stadler T., Rabosky D.L.,
RA Honeycutt R.L., Flynn J.J., Ingram C.M., Steiner C., Williams T.L.,
RA Robinson T.J., Burk-Herrick A., Westerman M., Ayoub N.A., Springer M.S.,
RA Murphy W.J.;
RT "Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on
RT mammal diversification.";
RL Science 334:521-524(2011).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; U97534; AAB65641.1; -; Genomic_DNA.
DR EMBL; JN415023; AEP18850.1; -; Genomic_DNA.
DR AlphaFoldDB; O18936; -.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF00092; VWA; 2.
DR Pfam; PF16164; VWA_N2; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..216
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 261..416
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAB65641.1"
FT NON_TER 416
FT /evidence="ECO:0000313|EMBL:AAB65641.1"
SQ SEQUENCE 416 AA; 46310 MW; CF8038F2886A59CB CRC64;
QEPGGGVLPP TTAPVSVTTP YVEDIPEAPL HDLYCSKLLD LVFLLDGSAK LSEAEFEMLK
VFVVGMMERL HISQKRIRVA VVEYHDGSHA YIELRDRKRP SELRRIAGQV KYAGSQVAST
SEVLKYTLFQ IFSKADRPEA SRIVLLLTAS EEPPRMARNL VRYVQGLKKK KVIVIPVGIG
PHASLKQIRL IEKQAPENKA FVFSSVDELE QRRDEIINYL CDLAPEAPAP TQPPDMAQVT
VGPGILGVSS PGPTRSSMIL DVVFILEGSD KVGEVNFNRI KEFMEEVIQR MDVGQDSIHI
TVLQYSYMVT VEYTFSEAQS KGDILQHVRE IRYRGGNRTN TGLALEYISE HSFSTSQGNR
EQAPNLVYMV TANPASDVIR RLPGDIQVVP IGVGPHANVQ ELERMAWPNA PILIQD
//
