ID NDUS3_RECAM Reviewed; 204 AA.
AC O21271;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 13-SEP-2023, entry version 94.
DE RecName: Full=NADH-ubiquinone oxidoreductase subunit 9;
DE EC=7.1.1.2;
GN Name=NAD9;
OS Reclinomonas americana.
OG Mitochondrion.
OC Eukaryota; Discoba; Jakobida; Histionina; Histionidae; Reclinomonas.
OX NCBI_TaxID=48483;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 50394;
RX PubMed=9168110; DOI=10.1038/387493a0;
RA Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C.,
RA Sankoff D., Turmel M., Gray M.W.;
RT "An ancestral mitochondrial DNA resembling a eubacterial genome in
RT miniature.";
RL Nature 387:493-497(1997).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Complex I is composed of about 30 different subunits.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
CC Note=Matrix and cytoplasmic side of the mitochondrial inner membrane.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I 30 kDa subunit family.
CC {ECO:0000305}.
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DR EMBL; AF007261; AAD11898.1; -; Genomic_DNA.
DR PIR; S78165; S78165.
DR RefSeq; NP_044783.1; NC_001823.1.
DR AlphaFoldDB; O21271; -.
DR SMR; O21271; -.
DR GeneID; 801075; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.460.80; NADH:ubiquinone oxidoreductase, 30kDa subunit; 1.
DR HAMAP; MF_01357; NDH1_NuoC; 1.
DR InterPro; IPR010218; NADH_DH_suC.
DR InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR InterPro; IPR020396; NADH_UbQ_OxRdtase_CS.
DR NCBIfam; TIGR01961; NuoC_fam; 1.
DR PANTHER; PTHR10884:SF14; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL; 1.
DR PANTHER; PTHR10884; NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3; 1.
DR Pfam; PF00329; Complex1_30kDa; 1.
DR SUPFAM; SSF143243; Nqo5-like; 1.
DR PROSITE; PS00542; COMPLEX1_30K; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Oxidoreductase; Respiratory chain; Translocase; Transport; Ubiquinone.
FT CHAIN 1..204
FT /note="NADH-ubiquinone oxidoreductase subunit 9"
FT /id="PRO_0000118649"
SQ SEQUENCE 204 AA; 24239 MW; 8AA999B21913AEC6 CRC64;
MKKQEQNQFL KEFGISLIKM FPKYIDKAIY SKGELTLHVK PTNLIALMKI LKNHTNCQFK
SLSDLCAVDF PEKKERFEIV YNLLSVRYNS RIRVKTFVDE LTPVPSVTCL FQAAGWFERE
VWDLFGVYFT NHPDLRRILT DYGFEGHPMR KDFPLTGYVE VRYDDEQKRV VTESLEMTQE
FRSFNFTSPW EQIEISKPNI KEKK
//
